Selumetinib Activity in Thyroid Cancer Cells: Modulation of Sodium Iodide Symporter and Associated miRNAs

Autor: Sabine Wächter, Annette Wunderlich, Brandon H. Greene, Silvia Roth, Moritz Elxnat, Sebastian A. Fellinger, Frederik A. Verburg, Markus Luster, Detlef K. Bartsch, Pietro Di Fazio

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 7, p 2077 (2018)

Background: The MEK (mitogen-activated protein kinase)–inhibitor selumetinib led to increased radioiodine uptake and retention in a subgroup of patients suffering from radioiodine refractory differentiated thyroid cancer (RR-DTC). We aimed to analy

Externí odkaz: https://doaj.org/article/aaa78e7334f744e6b11c193ff96d9986

Epigenetic Modifications in Thyroid Cancer Cells Restore NIS and Radio-Iodine Uptake and Promote Cell Death

Autor: Moritz Elxnat, Frederik A. Verburg, Pietro Di Fazio, Sabine Wächter, Detlef K. Bartsch, Alexander I. Damanakis, Silvia Roth, Annette Wunderlich, Sebastian A Fellinger

Publikováno v: Journal of Clinical Medicine
Journal of Clinical Medicine; Volume 7; Issue 4; Pages: 61
Journal of Clinical Medicine, Vol 7, Iss 4, p 61 (2018)

Epigenetic modifications have been identified as being responsible for the de-differentiation of thyroid tissue and its malignant transformation. Cell proliferation inhibitory effects of the pan-deacetylase inhibitors panobinostat, SAHA and Trichosta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e189da6904c775886c4f255a6e3ddf91
https://doi.org/10.3390/jcm7040061