Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Moritz, von Scheidt"'
Distinct genetic liability profiles define clinically relevant patient strata across common diseases
Autor:
Lucia Trastulla, Georgii Dolgalev, Sylvain Moser, Laura T. Jiménez-Barrón, Till F. M. Andlauer, Moritz von Scheidt, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Monika Budde, Urs Heilbronner, Sergi Papiol, Alexander Teumer, Georg Homuth, Henry Völzke, Marcus Dörr, Peter Falkai, Thomas G. Schulze, Julien Gagneur, Francesco Iorio, Bertram Müller-Myhsok, Heribert Schunkert, Michael J. Ziller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-28 (2024)
Abstract Stratified medicine holds great promise to tailor treatment to the needs of individual patients. While genetics holds great potential to aid patient stratification, it remains a major challenge to operationalize complex genetic risk factor p
Externí odkaz:
https://doaj.org/article/00e3ef22c51b4762863b27a5f510cabb
Platelet mass cytometry reveals dysregulation of prothrombotic pathways in essential thrombocythemia
Autor:
Veronika Dill, Kilian Kirmes, Jiaying Han, Melissa Klug, Marc Rosenbaum, Giacomo Viggiani, Moritz von Scheidt, Markus List, Peter Herhaus, Jürgen Ruland, Florian Bassermann, Karl-Ludwig Laugwitz, Katharina S. Götze, Philipp J. Jost, Stefanie Jilg, Conor J. Bloxham, Philip W.J. Raake, Isabell Bernlochner, Dario Bongiovanni
Publikováno v:
Platelets, Vol 35, Iss 1 (2024)
Thromboembolic events are common in patients with essential thrombocythemia (ET). However, the pathophysiological mechanisms underlying the increased thrombotic risk remain to be determined. Here, we perform the first phenotypical characterization of
Externí odkaz:
https://doaj.org/article/6b03b9ff955e40ae9ff5ee319c518d34
Autor:
Lara Marie Reimer, Leon Nissen, Moritz von Scheidt, Benedikt Perl, Jens Wiehler, Sinann Al Najem, Florian P. Limbourg, Theodora Tacke, Angelina Müller, Stephan Jonas, Heribert Schunkert, Fabian Starnecker
Publikováno v:
Digital Health, Vol 10 (2024)
Background Mobile health (mHealth) apps can be used for cardiovascular disease (CVD) prevention. User-centered design, evidence-based content and user testing can be applied to ensure a high level of usability and adequate app access. Objective To de
Externí odkaz:
https://doaj.org/article/b63507df89474582a2b33992c64a0764
Autor:
Fabian Starnecker, Lara Marie Reimer, Leon Nissen, Marko Jovanović, Maximilian Kapsecker, Susanne Rospleszcz, Moritz von Scheidt, Johannes Krefting, Nils Krüger, Benedikt Perl, Jens Wiehler, Ruoyu Sun, Stephan Jonas, Heribert Schunkert
Publikováno v:
JMIR Cardio, Vol 7, p e50813 (2023)
BackgroundIdentifying high-risk individuals is crucial for preventing cardiovascular diseases (CVDs). Currently, risk assessment is mostly performed by physicians. Mobile health apps could help decouple the determination of risk from medical resource
Externí odkaz:
https://doaj.org/article/d357fea41fb8479bacd4f519bfa9a49a
Autor:
Melissa Klug, Kilian Kirmes, Jiaying Han, Olga Lazareva, Marc Rosenbaum, Giacomo Viggiani, Moritz von Scheidt, Jürgen Ruland, Jan Baumbach, Gianluigi Condorelli, Karl-Ludwig Laugwitz, Markus List, Isabell Bernlochner, Dario Bongiovanni
Publikováno v:
Platelets, Vol 33, Iss 6, Pp 841-848 (2022)
Mass cytometry (CyTOF) is a new technology that allows the investigation of protein expression at single cell level with high resolution. While several protocols are available to investigate leukocyte expression, platelet staining and analysis with C
Externí odkaz:
https://doaj.org/article/7fc3a8132ec841acad8e1aeef211a611
Autor:
Johannes Krefting, Partho Sen, Diana David-Rus, Ulrich Güldener, Johann S. Hawe, Salvatore Cassese, Moritz von Scheidt, Heribert Schunkert
Publikováno v:
Frontiers in Artificial Intelligence, Vol 6 (2023)
Outcome research that supports guideline recommendations for primary and secondary preventions largely depends on the data obtained from clinical trials or selected hospital populations. The exponentially growing amount of real-world medical data cou
Externí odkaz:
https://doaj.org/article/7f66a61a23014d10b5d49db728237188
Autor:
Tibor Schuster, Adnan Kastrati, Shinsuke Yuasa, Erion Xhepa, Christian Kupatt, Michael Joner, Karl-Ludwig Laugwitz, Heribert Schunkert, Mark Lachmann, Elena Rippen, Moritz von Scheidt, Teresa Trenkwalder, Costanza Pellegrini, Tobias Rheude, Amelie Hesse, Anja Stundl, Gerhard Harmsen
Publikováno v:
Open Heart, Vol 9, Iss 2 (2022)
Objective A novel artificial intelligence-based phenotyping approach to stratify patients with severe aortic stenosis (AS) prior to transcatheter aortic valve replacement (TAVR) has been proposed, based on echocardiographic and haemodynamic data. Thi
Externí odkaz:
https://doaj.org/article/e7d13f294b5942d49abaacca1883ec72
Autor:
Maria Elishaev, Chani J. Hodonsky, Saikat Kumar B. Ghosh, Aloke V. Finn, Moritz von Scheidt, Ying Wang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Over the last few years, new high-throughput biotechnologies and bioinformatic methods are revolutionizing our way of deep profiling tissue specimens at the molecular levels. These recent innovations provide opportunities to advance our understanding
Externí odkaz:
https://doaj.org/article/80f9881c55984366ae72f1bed394d48b
Autor:
Isabell Bernlochner, Melissa Klug, Ditya Larasati, Moritz Von Scheidt, Donato Santovito, Michael Hristov, Christian Weber, Karl-Ludwig Laugwitz, Dario Bongiovanni
Publikováno v:
Platelets, Vol 32, Iss 1, Pp 113-119 (2021)
Reticulated Platelets (RPs) are large, RNA-rich, prothrombotic and hyperactive platelets known to be elevated in high-risk populations such as diabetics and patients with acute coronary syndrome. High levels of RPs correlate with mortality and advers
Externí odkaz:
https://doaj.org/article/c8825c22545d411185406daf60f62f42
Autor:
Dario Bongiovanni, Melissa Klug, Olga Lazareva, Simon Weidlich, Marina Biasi, Simona Ursu, Sarah Warth, Christian Buske, Marina Lukas, Christoph D. Spinner, Moritz von Scheidt, Gianluigi Condorelli, Jan Baumbach, Karl-Ludwig Laugwitz, Markus List, Isabell Bernlochner
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-10 (2021)
Abstract Novel coronavirus disease 2019 (COVID-19) is associated with a hypercoagulable state, characterized by abnormal coagulation parameters and by increased incidence of cardiovascular complications. With this study, we aimed to investigate the a
Externí odkaz:
https://doaj.org/article/888aef1470164dc099f54eb80c115899