Malonylation of GAPDH is an inflammatory signal in macrophages

Autor: Silvia Galván-Peña, Richard G. Carroll, Carla Newman, Elizabeth C. Hinchy, Eva Palsson-McDermott, Elektra K. Robinson, Sergio Covarrubias, Alan Nadin, Andrew M. James, Moritz Haneklaus, Susan Carpenter, Vincent P. Kelly, Michael P. Murphy, Louise K. Modis, Luke A. O’Neill

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Host metabolic reprogramming plays a role in functional responses against pathogens. Here, the authors characterise malonylated proteins in macrophages and show that malonylation of the glycolytic enzyme GAPDH impacts cytokine production by modulatin

Externí odkaz: https://doaj.org/article/4a15ae022f184e95bae97dad5d2e7a5a

Abstract 2751: ENIGMACTM discovery platform enables gene to function target validation for macrophage therapy

Autor: Martha Lopez-Yrigoyen, Thomas W. Monteiro Crozier, Helena Engman, Yuxin Cui, Moritz Haneklaus, Krzysztof B. Wicher, Stephen Myatt, Jeffrey W. Pollard, Luca Cassetta, Carola Ries

Publikováno v: Cancer Research. 83:2751-2751

The advent of Single cell RNA sequencing (scRNA-seq) has improved our understanding of cellular heterogeneity by providing in-depth transcriptome information at the single cell level. Several scRNA-seq papers reported sequencing of the tumor CD45 pos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d964f7179f13a29f63e992de6028ac7
https://doi.org/10.1158/1538-7445.am2023-2751

Tumour necrosis factor induces increased production of extracellular amyloid-β- and α-synuclein-containing aggregates by human Alzheimer’s disease neurons

Autor: Philip W. Brownjohn, Daniel R. Whiten, Yukun Zuo, Alessio Strano, Frederick J. Livesey, David Klenerman, Moritz Haneklaus, Steven Moore, Suman De

Publikováno v: Brain Communications

In addition to increased aberrant protein aggregation, inflammation has been proposed as a key element in the pathogenesis and progression of Alzheimer’s disease. How inflammation interacts with other disease pathways and how protein aggregation in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab039135c8c912652a8d9ccd2efc77d
https://doi.org/10.1093/braincomms/fcaa146

The Induction of Pro–IL-1β by Lipopolysaccharide Requires Endogenous Prostaglandin E2 Production

Autor: Deepthi Menon, Ewelina Flis, Hannah Prendeville, Eva M. Palsson-McDermott, Sarah E. Corcoran, Moritz Haneklaus, Marc Peters-Golden, Zbigniew Zaslona, Luke A. J. O'Neill

Publikováno v: The Journal of Immunology. 198:3558-3564

PGE2 has been shown to increase the transcription of pro–IL-1β. However, recently it has been demonstrated that PGE2 can block the maturation of IL-1β by inhibiting the NLRP3 inflammasome in macrophages. These apparently conflicting results have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee4843811ce2649a4cd3c4415e3ea9f3
https://doi.org/10.4049/jimmunol.1602072

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome

Autor: Owen Jensen, Matthias Mack, Luke A. J. O'Neill, Kelley S. Brodsky, Mark E. Cooper, Kathryn A. Biette, Charles A. Dinarello, Eóin N. McNamee, Seth L. Masters, Hazel Tye, Moritz Haneklaus, Glenn T. Furuta, Viola Neudecker, Holger K. Eltzschig, Paul Jedlicka, Avril A. B. Robertson, Mark E. Gerich, Ludmila Khailova, Joanne C. Masterson

Publikováno v: Journal of Experimental Medicine, 214, 1737-1752
Journal of Experimental Medicine, 214, 6, pp. 1737-1752
The Journal of Experimental Medicine

Neudecker et al. define a role for a microRNA, miR-223, in regulating the inflammatory tone of the intestine by constraining nlrp3 inflammasome activation in CCR2+ monocytes and attenuating excessive IL-1β–driven inflammation. Therapeutic nanopart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6adc7a6b2f77b5c7ae776e147b187fa8
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/174781