Výsledky vyhledávání - "Moritz, Eidens"

Development of an Isothermal Point-of-Care Genetic rapid test for the detection of the HLA-B*57:01 Allele, a predictor for Hypersensitivity reaction caused by Abacavir, for stratifying patients for Antiretroviral Abacavir HIV therapy

Autor: Alexander E. Jacobsen, Antje Jüngling, Corinna Gorges, Moritz Eidens

Publikováno v: Current Pharmacogenomics and Personalized Medicine. 20

Background: Abacavir is used in the treatment of HIV-infected patients. A hypersensitive reaction (HSR) occurs in about 5-8% of patients treated with Abacavir. The HLA-B*57:01 allele is a valuable predictor for HSR and its screening is mandatory prio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72588be8ff20b455c07987f58167dcac
https://doi.org/10.2174/1875692120666230206141327

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Actionable Nutrigenetics for Genetically Based Diseases? A New Critical Path to P4 Medicine

Autor: Alexander Weise, Marco Klemm, Wolfdieter Braun, Matthias M. Weber, Maria-Paz Weisshaar, Merle Fleischer, Moritz Eidens, Stefan Prause, Marion Lorenz

Publikováno v: Current Pharmacogenomics and Personalized Medicine. 11:167-180

Nutrigenomics and nutrigenetics are receiving growing attention from a diverse range of stakeholders including health care professionals, citizens, governments, insurers and industry. Currently there is special focus on research on how our food influ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df02f2e4c3db22f528c4a0037789f209
https://doi.org/10.2174/1875692111311020009

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Development and Validation of a High-Throughput Screening Method for Two Polymorphisms in the Serotonin Transporter Gene

Autor: Alexander Weise, Mathias Max Weber, Annette Wunsch, Norbert Dahmen, Moritz Eidens, Thomas Forst, Andreas Pfützner, Stefan Prause

Publikováno v: Molecular Diagnosis & Therapy. 13:25-29

Background and Aim: The human serotonin (5-hydroxytryptamine) transporter, encoded by the SLC6A4 gene on chromosome 17q11.1–q12, is the cellular reuptake site for serotonin and a site of action for several drugs with central nervous system effects,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3052424834bd679c1c8a71ef64a63c4
https://doi.org/10.1007/bf03256312

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Development and Validation of a Rapid and Reliable Real-Time PCR Method for CYP3A5 Genotyping

Autor: Marco Klemm, Moritz Eidens, Alexander Weise, Stefan Prause, Merle Fleischer

Publikováno v: Clinical Laboratory. 61

BACKGROUND A prominent example for inter-individual differences in drug-metabolizing enzymes is the cytochrome P450 family. These monooxygenases comprise enzymes responsible for metabolism of about 90% of common medications. CYP3A5 and CYP3A4 account

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f4bda16555eb313b347fa564aafcdb
https://doi.org/10.7754/clin.lab.2014.140827

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Pharmacogenetic prediction of individual variability in drug response based on CYP2D6, CYP2C9 and CYP2C19 genetic polymorphisms

Autor: Shafqat Rasul Chaudhry, Marco Klemm, Maria-Paz Weisshaar, Sajjad Muhammad, Thomas Efferth, Moritz Eidens, Dilaware Khan

Publikováno v: Current drug metabolism. 15(7)

Interindividual variability in drug response depends on a number of genetic and environmental factors. The metabolic enzymes are well known for their contribution to this variability due to drug-drug interactions and genetic polymorphisms. The phase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d88143058e0f2ea0c3e66b3bb8f99be
https://pubmed.ncbi.nlm.nih.gov/25429673

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Development and Validation of a Rapid and Reliable Method for TPMT Genotyping using real-time PCR

Autor: Andreas Pfützner, Stefan Prause, Marion Lorenz, Moritz Eidens, Thomas Forst, Alexander Weise, Marco Klemm, Matthias M. Weber, Massimiliano Luchi

Publikováno v: Clinical Laboratory. 59

Background It is widely accepted that many medications exhibit inter-individual variability in their efficacy and toxicity due to polymorphisms in genes encoding drug-metabolising enzymes. One of the most often cited examples in this context is thiop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09aa2c69cd68d10a535ddca225936303
https://doi.org/10.7754/clin.lab.2011.111009

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Development and validation of a rapid and reliable method for TPMT genotyping using real-time PCR

Autor: Marion, Lorenz, Alexander, Weise, Stefan, Prause, Marco, Klemm, Moritz, Eidens, Massimiliano, Luchi, Thomas, Forst, Andreas, Pfützner, Matthias M, Weber

Publikováno v: Clinical laboratory. 58(9-10)

It is widely accepted that many medications exhibit inter-individual variability in their efficacy and toxicity due to polymorphisms in genes encoding drug-metabolising enzymes. One of the most often cited examples in this context is thiopurine S-met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2f4e03d225bd78195ce86055e424c402
https://pubmed.ncbi.nlm.nih.gov/23163112

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