Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Morito Endo"'
Autor:
Kei Utsunomiya, Takashi Maruyama, Satoshi Shimizu, Taro Matsumoto, Morito Endo, Hiroki Kobayashi, Koichiro Kano, Masanori Abe, Noboru Fukuda
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-14 (2022)
Abstract Introduction The implantation of dedifferentiated fat (DFAT) cells has been shown to exert immunosuppressive effects. To develop DFAT cell therapy for antineutrophil cytoplasmic antibody (ANCA) glomerulonephritis, the effects of the implanta
Externí odkaz:
https://doaj.org/article/09823ac166d04f19ac790beaa151a518
Autor:
Makiyo Okamura, Noboru Fukuda, Shu Horikoshi, Hiroki Kobayashi, Akiko Tsunemi, Yurie Akiya, Morito Endo, Taro Matsumoto, Masanori Abe
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4741 (2021)
Upstream stimulatory factor 1 (USF1) is a transcription factor that is increased in high-glucose conditions and activates the transforming growth factor (TGF)-β1 promoter. We examined the effects of synthetic pyrrole-imidazole (PI) polyamides in pre
Externí odkaz:
https://doaj.org/article/72f835aae5074025bae4dad97327aee1
Autor:
Maki Kitai, Noboru Fukuda, Takahiro Ueno, Morito Endo, Takashi Maruyama, Masanori Abe, Kazuyoshi Okada, Masayoshi Soma, Koichi Matsumoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 134, Iss 1, Pp 29-36 (2017)
The Fc receptors (FcR) have pivotal roles in the pathogenesis of the autoimmune glomerulonephritis. We therefore investigated the effects of a Syk inhibitor on the progression of lupus nephritis and SH3 domain binding protein 2 and p38MAP kinase sign
Externí odkaz:
https://doaj.org/article/fa7cb2e074284727a54160abe18929c0
Autor:
Shu Horikoshi, Noboru Fukuda, Akiko Tsunemi, Makiyo Okamura, Masari Otsuki, Morito Endo, Masanori Abe
Publikováno v:
Molecules, Vol 25, Iss 4, p 950 (2020)
TGF-β1 has been known to induce diabetic nephropathy with renal fibrosis and glomerulosclerosis. DNA-recognized peptide compound pyrrole-imidazole (PI) polyamides as novel biomedicines can strongly bind promoter lesions of target genes to inhibit it
Externí odkaz:
https://doaj.org/article/d1eb4639c2734a7794b22d5603733374
Autor:
Masari Otsuki, Noboru Fukuda, Takashi Inoue, Takayuki Mineshige, Tomoyasu Otsuki, Shu Horikoshi, Morito Endo, Masanori Abe
Publikováno v:
Molecules, Vol 24, Iss 17, p 3178 (2019)
Pyrrole-imidazole (PI) polyamides are novel gene silencers that strongly bind the promoter region of target genes in a sequence-specific manner to inhibit gene transcription. We created a PI polyamide targeting human TGF-β1 (hTGF-β1). To develop th
Externí odkaz:
https://doaj.org/article/52bb5f1ac1b6447b803ea87f54d620cb
Autor:
Jin Ikeda, Hiroyuki Matsuda, Masayoshi Soma, Yukimoto Ishii, Kenya Yamaguchi, Maiko Ogasawara, Morito Endo, Yoshikazu Masuhiro, Satoru Takahashi, Noboru Fukuda, Pavel Hamet, Johanne Tremblay
Publikováno v:
Anticancer Research. 41:2805-2815
Background/aim Copper metabolism MURR1 domain-containing 5 (COMMD5) is mainly expressed in renal tubules (RTs), where it facilitates re-differentiation of injured RTs. We reported that COMMD5 regulates the expression of epidermal growth factor recept
Autor:
Kei Utsunomiya, Satoshi Shimizu, Taro Matsumoto, Morito Endo, Koichiro Kano, Noboru Fukuda, Takashi Maruyama, Masanori Abe
Background We established an adipogenic progenitor cell line derived from mature adipocytes and named these cells dedifferentiated fat (DFAT) cells, which have been shown to have characteristics very similar to those of mesenchymal stem cells (MSCs).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::986d0b889d430d0487814b7a2cb5e9a2
https://doi.org/10.21203/rs.3.rs-1032501/v1
https://doi.org/10.21203/rs.3.rs-1032501/v1
Autor:
Masanori Abe, Satoshi Shimizu, Koichiro Kano, Hiroki Kobayashi, Morito Endo, Takashi Maruyama, Noboru Fukuda, Taro Matsumoto, Kei Utsunomiya
We examined the effects of implantation of dedifferentiated fat (DFAT) cells on renal function, proteinuria and glomerulonephritis in SCG mice as a preclinical study of DFAT cell therapy for antineutrophil cytoplasmic antibody (ANCA) glomerulonephrit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bd117d263c65220e27309042e9d9544
https://doi.org/10.21203/rs.3.rs-934207/v1
https://doi.org/10.21203/rs.3.rs-934207/v1
Autor:
Kei Utsunomiya, Takashi Maruyama, Satoshi Shimizu, Taro Matsumoto, Morito Endo, Hiroki Kobayashi, Koichiro Kano, Masanori Abe, Noboru Fukuda
Publikováno v:
Stem cell researchtherapy. 13(1)
Introduction The implantation of dedifferentiated fat (DFAT) cells has been shown to exert immunosuppressive effects. To develop DFAT cell therapy for antineutrophil cytoplasmic antibody (ANCA) glomerulonephritis, the effects of the implantation of D
Autor:
Akira Nishiyama, Morito Endo, Eriko Negishi, Sho Tanaka, Yoshinari Hatanaka, Masanaori Abe, Kazutoshi Komatsu, Lan Chen, Takahiro Ueno, Hiroki Kobayashi, Noboru Fukuda, Tomoji Mashimo, Tomoyasu Otsuki, Mayumi Katakawa
Publikováno v:
American Journal of Physiology-Renal Physiology. 315:F1747-F1758
We previously showed that complement 3 (C3) is highly expressed in mesenchymal tissues in spontaneously hypertensive rats (SHR). We targeted C3 gene by zinc-finger nuclease (ZFN) gene-editing technology and investigated blood pressure and phenotype i