Výsledky vyhledávání - "Morito, Sakaue"

Akademický článek

The Temporal Order of DNA Replication Shaped by Mammalian DNA Methyltransferases

Autor: Shin-ichiro Takebayashi, Tyrone Ryba, Kelsey Wimbish, Takuya Hayakawa, Morito Sakaue, Kenji Kuriya, Saori Takahashi, Shin Ogata, Ichiro Hiratani, Katsuzumi Okumura, Masaki Okano, Masato Ogata

Publikováno v: Cells, Vol 10, Iss 2, p 266 (2021)

Multiple epigenetic pathways underlie the temporal order of DNA replication (replication timing) in the contexts of development and disease. DNA methylation by DNA methyltransferases (Dnmts) and downstream chromatin reorganization and transcriptional

Externí odkaz: https://doaj.org/article/34deeb6edbe3441688a6f882879d3d02

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Akademický článek

IGF-1 Gene Transfer to Human Synovial MSCs Promotes Their Chondrogenic Differentiation Potential without Induction of the Hypertrophic Phenotype

Autor: Yasutoshi Ikeda, Morito Sakaue, Ryota Chijimatsu, David A. Hart, Hidenori Otsubo, Kazunori Shimomura, Henning Madry, Tomoyuki Suzuki, Hideki Yoshikawa, Toshihiko Yamashita, Norimasa Nakamura

Publikováno v: Stem Cells International, Vol 2017 (2017)

Mesenchymal stem cell- (MSC-) based therapy is a promising treatment for cartilage. However, repair tissue in general fails to regenerate an original hyaline-like tissue. In this study, we focused on increasing the expression levels for insulin-like

Externí odkaz: https://doaj.org/article/6caf7c7064bc41429fc668ea99899532

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First-in-Human Pilot Study of Implantation of a Scaffold-Free Tissue-Engineered Construct Generated From Autologous Synovial Mesenchymal Stem Cells for Repair of Knee Chondral Lesions

Autor: Norimasa Nakamura, Norihiko Sugita, Shuji Horibe, Kazunori Shimomura, Takashi Kanamoto, Yukihiko Yasui, Yu Moriguchi, Hideki Yoshikawa, Yasukazu Yonetani, Morito Sakaue, Takashi Nishii, David A. Hart, Ryota Chijimatsu, Wataru Ando, Kota Koizumi

Publikováno v: The American Journal of Sports Medicine. 46:2384-2393

Background: Articular cartilage has limited healing capacity, owing in part to poor vascularity and innervation. Once injured, it cannot be repaired, typically leading to high risk for developing osteoarthritis. Thus, cell-based and/or tissue-enginee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241c97082c0ebed2b9bb3ac2a51b29a8
https://doi.org/10.1177/0363546518781825

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IGF-1 Gene Transfer to Human Synovial MSCs Promotes Their Chondrogenic Differentiation Potential without Induction of the Hypertrophic Phenotype

Autor: Ryota Chijimatsu, Yasutoshi Ikeda, Tomoyuki Suzuki, David A. Hart, Morito Sakaue, Toshihiko Yamashita, Hideki Yoshikawa, Hidenori Otsubo, Henning Madry, Kazunori Shimomura, Norimasa Nakamura

Publikováno v: Stem Cells International, Vol 2017 (2017)
Stem Cells International

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b845dcbfb20376c1a05dcdabd374dc
https://doi.org/10.1155/2017/5804147

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DS_10.1177_0363546518781825 – Supplemental material for First-in-Human Pilot Study of Implantation of a Scaffold-Free Tissue-Engineered Construct Generated From Autologous Synovial Mesenchymal Stem Cells for Repair of Knee Chondral Lesions

Autor: Shimomura, Kazunori, Yasui, Yukihiko, Koizumi, Kota, Chijimatsu, Ryota, Hart, David A., Yonetani, Yasukazu, Ando, Wataru, Nishii, Takashi, Kanamoto, Takashi, Horibe, Shuji, Yoshikawa, Hideki, Nakamura, Norimasa, Morito Sakaue, Norihiko Sugita, Moriguchi, Yu

Supplemental material, DS_10.1177_0363546518781825 for First-in-Human Pilot Study of Implantation of a Scaffold-Free Tissue-Engineered Construct Generated From Autologous Synovial Mesenchymal Stem Cells for Repair of Knee Chondral Lesions by Kazunori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c467337e15c4eb83321e0287ce43a0e

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Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b

Autor: Kunitada Shimotohno, Jun-ichi Nakayama, Akiko Tsumura, Shin-ichiro Takebayashi, Tomohiro Hayakawa, Hiroki R. Ueda, Morito Sakaue, Yuichi Kumaki, Masaki Okano, En Li, Fuyuki Ishikawa, Chisa Matsuoka

Publikováno v: Genes to Cells. 11:805-814

DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b cooperatively regulate cytosine methylation in CpG dinucleotides in mammalian genomes, providing an epigenetic basis for gene silencing and maintenance of genome integrity. Proper CpG methylation is req

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c04d132064cada06193f68ad7fd1c0
https://doi.org/10.1111/j.1365-2443.2006.00984.x

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Immune responses to repetitive adenovirus-mediated gene transfer and restoration of gene expression by cyclophosphamide or etoposide

Autor: William C. Satterfield, Asis K. Sarkar, Stepanie Buchl, Morito Sakaue, Michele Follen, Katsuyuki Hamada, Jack A. Roth, Michale E. Keeling, Jagannandha Sastry

Publikováno v: Gynecologic Oncology. 99:S177-S186

Background. One major concern about adenoviral vectors for repetitive gene delivery is the induction of an immune response to the vector, thus impeding effective gene transduction. Methods. To assess the immune response to the adenoviral vector, repe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2bc814e0d5504a633a1a3c246565422
https://doi.org/10.1016/j.ygyno.2005.07.078

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Induction of Egr-1 expression by the retinoid AHPN in human lung carcinoma cells is dependent on activated ERK1/2

Autor: Hiroshi Adachi, Marcia I. Dawson, Anton M. Jetten, Morito Sakaue

Publikováno v: Cell Death & Differentiation. 8:411-424

The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (AHPN/CD437) inhibits cell proliferation and is a very effective inducer of apoptosis in a variety of carcinoma cell lines. In order to obtain greater insight into t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f856ff4de6af94f2e133d3a0f0b2d972
https://doi.org/10.1038/sj.cdd.4400818

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Regulation of Cyclooxygenase-2 by Interferon γ and Transforming Growth Factor α in Normal Human Epidermal Keratinocytes and Squamous Carcinoma Cells

Autor: Tadashi Tanabe, Andrew J. Dannenberg, Hideki Kamitani, Hiroyasu Inoue, Anton M. Jetten, Jirô Arata, Thomas E. Eling, Morito Sakaue, Kotha Subbaramaiah, Hironori Matsuura

Publikováno v: Journal of Biological Chemistry. 274:29138-29148

Treatment of normal human epidermal keratinocytes (NHEK) with interferon-γ (IFN-γ) causes a 9-fold increase in the level of cyclooxygenase-2 (COX-2) mRNA expression. Nuclear run-off assays indicate that this induction is at least partly due to incr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d7bb3197ca804b7e772c920e74b5824
https://doi.org/10.1074/jbc.274.41.29138

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Adenovirus-Mediated Transfer of HPV 16E6/E7Antisense RNA to Human Cervical Cancer Cells

Autor: Michele Follen Mitchell, Morito Sakaue, Yoshitsugu Horio, Wei Wei Zhang, Ramon Alemany, Jack A. Roth, Katsuyuki Hamada

Publikováno v: Gynecologic Oncology. 63:219-227

To explore the potential of an adenoviral antisense RNA transcript for gene therapy of cervical cancer, we introduced the antisense RNA transcript of E6 and E7 genes of human papillomavirus (HPV) 16 into cervical cancer cells harboring HPV 16 via a r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d50abe7917dd85dcbd4a1908b23fdb
https://doi.org/10.1006/gyno.1996.0310

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