Zobrazeno 1 - 10
of 307
pro vyhledávání: '"Morikis, D."'
Publikováno v:
In Biophysical Journal 19 May 2010 98(10):2337-2346
Publikováno v:
In Molecular Immunology 2004 41(2):153-164
Autor:
Croker, D.E., Monk, P.N., Halai, R., Kaeslin, G., Schofield, Z., Wu, M.C., Clark, R.J., Blaskovich, M.A., Morikis, D., Floudas, C.A., Cooper, M.A., Woodruff, T.M.
The complement cascade is comprised of a highly sophisticated network of innate immune proteins that are activated in response to invading pathogens or tissue injury. The complement activation peptide, C5a, binds two seven transmembrane receptors, na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::a0bab07cfe066006326231ef64d928c8
https://eprints.whiterose.ac.uk/99923/10/ICB-15-OA-0061V2_merged.pdf
https://eprints.whiterose.ac.uk/99923/10/ICB-15-OA-0061V2_merged.pdf
Autor:
Tamamis, Phanourios, Skourtis, Spiros S., Morikis, D., Lambris, J. D., Archontis, Georgios Z.
Publikováno v:
Journal of Molecular Graphics and Modelling
J.Mol.Graph.Model.
J.Mol.Graph.Model.
The cyclic 13-residue peptide compstatin is a potential therapeutic agent against the unregulated activation of the complement system. A thorough knowledge of its structural and dynamical properties in solution may assist the design of improved compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c42cdc74d329de11c3da42930d9ef3
https://doi.org/10.1016/j.jmgm.2007.03.014
https://doi.org/10.1016/j.jmgm.2007.03.014
Publikováno v:
Journal of medicinal chemistry, vol 58, iss 24
Gorham, RD; Nuñez, V; Lin, JH; Rooijakkers, SHM; Vullev, VI; & Morikis, D. (2015). Discovery of Small Molecules for Fluorescent Detection of Complement Activation Product C3d. Journal of Medicinal Chemistry, 58(24), 9535-9545. doi: 10.1021/acs.jmedchem.5b01062. UC Riverside: Retrieved from: http://www.escholarship.org/uc/item/2888860h
Gorham, RD; Nuñez, V; Lin, JH; Rooijakkers, SHM; Vullev, VI; & Morikis, D. (2015). Discovery of Small Molecules for Fluorescent Detection of Complement Activation Product C3d. Journal of Medicinal Chemistry, 58(24), 9535-9545. doi: 10.1021/acs.jmedchem.5b01062. UC Riverside: Retrieved from: http://www.escholarship.org/uc/item/2888860h
© 2015 American Chemical Society. Complement activation plays a major role in many acute and chronic inflammatory conditions. C3d, a terminal product of complement activation, remains covalently attached to cells and is an excellent biomarker of com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::40a81faa356ec897289a77e16ea05050
https://escholarship.org/uc/item/2888860h
https://escholarship.org/uc/item/2888860h
Autor:
Halai, R., Bellows-Peterson, M.L., Branchett, W., Smadbeck, J., Kieslich, C.A., Croker, D.E., Cooper, M.A., Morikis, D., Woodruff, T.M., Floudas, C.A., Monk, P.N.
The complement cascade is a highly sophisticated network of proteins that are well regulated and directed in response to invading pathogens or tissue injury. Complement C3a and C5a are key mediators produced by this cascade, and their dysregulation h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::143019315e253eb4de6ba450c0b82e6d
Autor:
Gorham, R. D., Forest, D. L., Tamamis, Phanourios, López de Victoria, A., Kraszni, M., Kieslich, C. A., Banna, C. D., Bellows-Peterson, M. L., Larive, C. K., Floudas, C. A., Archontis, Georgios Z., Johnson, L. V., Morikis, D.
Publikováno v:
Experimental eye research
Exp.Eye Res.
Experimental Eye Research
Exp.Eye Res.
Experimental Eye Research
We have used a novel human retinal pigmented epithelial (RPE) cell-based model that mimics drusen biogenesis and the pathobiology of age-related macular degeneration to evaluate the efficacy of newly designed peptide inhibitors of the complement syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50cdd32a7a5e97020174518c22671166
https://europepmc.org/articles/PMC3840162/
https://europepmc.org/articles/PMC3840162/
Autor:
Bellows-Peterson, M.L., Fung, H.K., Floudas, C.A., Kieslich, C.A., Zhang, L., Morikis, D., Wareham, K.J., Monk, P.N., Hawksworth, O.A., Woodruff, T.M.
Targeting the complement component 3a receptor (C3aR) with selective agonists or antagonists is believed to be a viable therapeutic option for several diseases such as stroke, heart attack, reperfusion injuries, and rheumatoid arthritis. We designed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::c7c5b55f83223b8c56c523677f8ea1ea
https://eprints.whiterose.ac.uk/110863/1/nihms371412.pdf
https://eprints.whiterose.ac.uk/110863/1/nihms371412.pdf
Autor:
Tamamis, Phanourios, López de Victoria, A., Gorham, R. D., Bellows-Peterson, M. L., Pierou, P., Floudas, C. A., Morikis, D., Archontis, Georgios Z.
Publikováno v:
Chemical Biology and Drug Design
Chem.Biol.Drug Des.
Chem.Biol.Drug Des.
We report the computational and rational design of new generations of potential peptide-based inhibitors of the complement protein C3 from the compstatin family. The binding efficacy of the peptides is tested by extensive molecular dynamics-based str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______4485::6cf538761fd0e1ac42497394c99671c9
http://gnosis.library.ucy.ac.cy/handle/7/59111
http://gnosis.library.ucy.ac.cy/handle/7/59111
Autor:
Tamamis, Phanourios, Pierou, P., Mytidou, C., Floudas, C. A., Morikis, D., Archontis, Georgios Z.
Publikováno v:
Proteins: Structure, Function and Bioinformatics
Proteins Struct.Funct.Bioinformatics
Proteins Struct.Funct.Bioinformatics
The peptide compstatin and its derivatives inhibit the complement-component protein C3 in primate mammals and are potential therapeutic agents against the unregulated activation of complement in humans, but are inactive against C3 from lower mammals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______4485::f659ddb0b4f700fbc3fe72ee8a5ad04b
http://gnosis.library.ucy.ac.cy/handle/7/59113
http://gnosis.library.ucy.ac.cy/handle/7/59113