Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Morihisa Fujita"'
Autor:
Yan Yang, Guoyu Liu, Feng Li, Lucas B. Carey, Changjin Sun, Kaiping Ling, Hiroyuki Tachikawa, Morihisa Fujita, Xiao-Dong Gao, Hideki Nakanishi
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
The multiligand receptor RAGE (receptor for advanced glycation end-products) mediates phagocytosis in non-professional phagocytes (NPPs), for example through the use of RNA fragments as ligands for internalization.
Externí odkaz:
https://doaj.org/article/cbcdf27758094a80bd9a56966e5274eb
Autor:
Ganglong Yang, Chenyang Zuo, Yuxiang Lin, Xiaoman Zhou, Piaopiao Wen, Chairui Zhang, Han Xiao, Meichen Jiang, Morihisa Fujita, Xiao-Dong Gao, Fangmeng Fu
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundBreast cancer is one of the most frequently occurring malignant cancers worldwide. Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) are the two most common histological subtypes of breast cancer. In this study, we aimed
Externí odkaz:
https://doaj.org/article/2e2cb2ed767e40ebbd623f83b27c8bc1
Autor:
Si-Si Liu, Yi-Shi Liu, Xin-Yu Guo, Yoshiko Murakami, Ganglong Yang, Xiao-Dong Gao, Taroh Kinoshita, Morihisa Fujita
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Liu et al. construct a knock out cell library of genes involved in the biosynthesis of glycosylphosphatidylinositol (GPI)-anchored protein (GPI-APs) from HEK-293 cells and analyzed the surface expression and sensitivity to phosphatidylinositol-specif
Externí odkaz:
https://doaj.org/article/3671a2fc33684958a4cc3730bc6d41d1
Publikováno v:
Novel Research in Microbiology Journal, Vol 4, Iss 4, Pp 856-867 (2020)
Lipid droplets (LDs) are conserved specialized organelles that are surrounded by a single phospholipid layer, enclosing neutral lipids in form of triacylglycerol (TAG) and/or sterol ester. They are formed at the endoplasmic reticulum (ER), and stay
Externí odkaz:
https://doaj.org/article/0493b069209c446f9cd72c5a16a0da8b
Autor:
Yicheng Wang, Yusuke Maeda, Yi-Shi Liu, Yoko Takada, Akinori Ninomiya, Tetsuya Hirata, Morihisa Fujita, Yoshiko Murakami, Taroh Kinoshita
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Glycosylphosphatidylinositol (GPI) anchors are found on many cell surface proteins but their biosynthesis is not fully understood. Here, the authors identify genes involved in GPI galactosylation and reveal functional connections between GPI processi
Externí odkaz:
https://doaj.org/article/af50b6c2882743e491efc238b271b2f7
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, heparan sulfate, and keratan sulfate, except for hyaluronan that is a free polysaccharide, are covalently attached to core proteins to form proteoglycans. More than 50 gene pr
Externí odkaz:
https://doaj.org/article/3829a4a0b62341c9b5838ed4c0e44b2b
Publikováno v:
Cells, Vol 11, Iss 18, p 2775 (2022)
STT3A and STT3B are the main catalytic subunits of the oligosaccharyltransferase complex (OST-A and OST-B in mammalian cells), which primarily mediate cotranslational and post-translocational N-linked glycosylation, respectively. To determine the spe
Externí odkaz:
https://doaj.org/article/5d923a39470b4cc9b00995b153f602cf
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0250805 (2021)
A FLAG tag consisting of DYKDDDDK is an epitope tag that is frequently and widely used to detect recombinant proteins of interest. In this study, we performed a CRISPR-based genetic screening to identify factors involved in the detection of a FLAG-ta
Externí odkaz:
https://doaj.org/article/9a25ed81827643de90cd70a9dda83952
Autor:
Tetsuya Hirata, Sushil K. Mishra, Shota Nakamura, Kazunobu Saito, Daisuke Motooka, Yoko Takada, Noriyuki Kanzawa, Yoshiko Murakami, Yusuke Maeda, Morihisa Fujita, Yoshiki Yamaguchi, Taroh Kinoshita
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Mammalian GPI membrane anchors are modified by GalNAc to confer structural diversity but the biosynthetic pathway is poorly understood. Here, the authors identify and characterize the Golgi-resident GPI-GalNAc transferase PGAP4, providing insights in
Externí odkaz:
https://doaj.org/article/476885486e374cb9b0577fcd177b83ae
Autor:
Si-Si Liu, Fei Jin, Yi-Shi Liu, Yoshiko Murakami, Yukihiko Sugita, Takayuki Kato, Xiao-Dong Gao, Taroh Kinoshita, Motoyuki Hattori, Morihisa Fujita
Publikováno v:
Molecules, Vol 26, Iss 18, p 5462 (2021)
Glycosylphosphatidylinositol (GPI) anchor modification is a posttranslational modification of proteins that has been conserved in eukaryotes. The biosynthesis and transfer of GPI to proteins are carried out in the endoplasmic reticulum. Attachment of
Externí odkaz:
https://doaj.org/article/1243bbe3a95b4aab90632b9f330bf8b5