Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Morihiko, Hirota"'
Autor:
Hajime Kojima, Tokio Nakada, Akiko Yagami, Hiroaki Todo, Jihei Nishimura, Mio Yagi, Keiko Yamamoto, Mariko Sugiyama, Yoshiaki Ikarashi, Hitoshi Sakaguchi, Masahiko Yamaguchi, Morihiko Hirota, Sakiko Aizawa, Shota Nakagawa, Shigenobu Hagino, Masato Hatao
Publikováno v:
Current Research in Toxicology, Vol 4, Iss , Pp 100100- (2023)
Animal testing of cosmetic ingredients and products has been banned in the European Union since 2013. However, in Japan, the application of new quasi-drugs requires the generation of data on acute oral toxicity through animal testing. A weight of evi
Externí odkaz:
https://doaj.org/article/87dee5b26ae9496ab51c2bcc9ad2ae5d
Autor:
Toshiyuki Ohtake1 toshiyuki.otake@shiseido.com, Morihiko Hirota1
Publikováno v:
Journal of Toxicological Sciences. Mar2022, Vol. 47 Issue 3, p109-116. 8p.
Autor:
Hiroto, Ohtake, Yasuharu, Tokuyoshi, Yosuke, Iyama, Takumi, Nukaga, Hayato, Nishida, Toshiyuki, Ohtake, Morihiko, Hirota, Kohei, Yamada, Yoshiki, Seto, Hideyuki, Sato, Hirokazu, Kouzuki, Satomi, Onoue
Publikováno v:
The Journal of Toxicological Sciences. 47:483-492
A reactive oxygen species (ROS) assay has been widely used for photosafety assessment; however, the phototoxic potential of complex materials, including plant extracts, essential oils, and functional polymers, is unevaluable because of their undefine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::201667619c9ebcf8d4bef661b1c958f2
https://doi.org/10.2131/jts.47.483
https://doi.org/10.2131/jts.47.483
Autor:
Noriyasu, Imai, Midori, Takeyoshi, Sakiko, Aizawa, Mika, Tsurumaki, Masaharu, Kurosawa, Akemi, Toyoda, Maki, Sugiyama, Kaoru, Kasahara, Shinichi, Ogata, Takashi, Omori, Morihiko, Hirota
Publikováno v:
Journal of Applied Toxicology. 42:1029-1043
Demands for the elimination and replacement of animal experiments for cosmetic safety assessment have increased in recent years. Evaluation of skin sensitization, however, is a critical issue in cosmetic safety assessment. The SH test is an in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8cbe7e39d6ff4262575b584cc9de74
https://doi.org/10.1002/jat.4275
https://doi.org/10.1002/jat.4275
Autor:
Hiroaki Todo, Hitoshi Sakaguchi, Masahiko Yamaguchi, Akiko Yagami, Morihiko Hirota, Hidefumi Ikeda, Masato Hatao, Keiko Yamamoto, Tokio Nakada, Mariko Sugiyama, Hajime Kojima, Mio Yagi, Yoshiaki Ikarashi, Noriyasu Imai, Jihei Nishimura
Publikováno v:
Applied In Vitro Toxicology. 7:144-154
Introduction: Animal tests of cosmetic ingredients and products have been banned in the EU since 2013. However, in Japan, the application of new quasi-drugs requires the generation of 24-hour data ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b9cb28c71592e27a1e151419ebc51f7
https://doi.org/10.1089/aivt.2021.0016
https://doi.org/10.1089/aivt.2021.0016
Autor:
Maki Sugiyama, Morihiko Hirota, Midori Takeyoshi, Noriyasu Imai, Sakiko Aizawa, Masaharu Kurosawa, Kaoru Kasahara, Mika Tsurumaki, Akemi Toyoda, Shinichi Ogata
Publikováno v:
The Journal of Toxicological Sciences. 46:235-248
There has been an increased demand to eliminate animal experiments and to replace the experiments with alternative tests for assessing the safety of cosmetics. The SH test is an in vitro skin sensitization test that evaluates the protein binding abil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73d7a133fb67d5cd15f3998a37ef136c
https://doi.org/10.2131/jts.46.235
https://doi.org/10.2131/jts.46.235
Publikováno v:
The Journal of Toxicological Sciences. 45:95-108
We present a systematic, comprehensive and reproducible weight-of-evidence approach for predicting the no-observed-adverse-effect level (NOAEL) for systemic toxicity by using read-across and quantitative structure-activity relationship (QSAR) models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abab5697ac3412b4e18bd3762085478a
https://doi.org/10.2131/jts.45.95
https://doi.org/10.2131/jts.45.95
Autor:
Noriyasu, Imai, Midori, Takeyoshi, Sakiko, Aizawa, Mika, Tsurumaki, Masaharu, Kurosawa, Akemi, Toyoda, Maki, Sugiyama, Kaoru, Kasahara, Morihiko, Hirota, Shinichi, Ogata
Publikováno v:
The Journal of toxicological sciences. 46(5)
There has been an increased demand to eliminate animal experiments and to replace the experiments with alternative tests for assessing the safety of cosmetics. The SH test is an in vitro skin sensitization test that evaluates the protein binding abil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9cc0f82ff664b2b2dda9f556802623f7
https://pubmed.ncbi.nlm.nih.gov/33952800
https://pubmed.ncbi.nlm.nih.gov/33952800
Autor:
Nathalie Alépée, Dirk Petersohn, Sebastian Hoffmann, Elodie Clouet, Petra S. Kern, Martina Klaric, Jochen Kühnl, Hayato Nishida, Dagmar Bury, Morihiko Hirota, Erwin van Vliet, Masaaki Miyazawa, Nicola Gilmour, Anne Osmani, Karsten Rüdiger Mewes, Shuichi Sekine, Fanny Boisleve, Jon F. Lalko
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 116
All cosmetic products placed onto the market must undergo a risk assessment for human health to ensure they are safe for consumers, including an assessment of skin sensitisation risk. Historically, in vivo animal test methods were used to identify an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1153e49efd503c4c865b6d0ffc291a2e
https://pubmed.ncbi.nlm.nih.gov/32645429
https://pubmed.ncbi.nlm.nih.gov/32645429
Autor:
Atsushi Kodama, Moemi Kawaguchi, Hirokazu Kouzuki, Morihiko Hirota, Kousei Ito, Takumi Nukaga, Akinori Takemura, Shuichi Sekine, Shiho Oeda, Takeshi Susukida
Publikováno v:
Toxicology and applied pharmacology. 394
Drug-induced liver injury (DILI) can cause hepatic failure and result in drug withdrawal from the market. It has host-related and compound-dependent mechanisms. Preclinical prediction of DILI risk is very challenging and safety assessments based on a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6219920640b7d307a3ef1cd8d25156
https://pubmed.ncbi.nlm.nih.gov/32198022
https://pubmed.ncbi.nlm.nih.gov/32198022