Výsledky vyhledávání - "Moriarty, R. M."

Prevention of preneoplastic mammary lesion development by a novel vitamin D analogue, 1α-hydroxyvitamin D5

Autor: Mehta, R. G., Moriarty, R. M., Mehta, R. R., Penmasta, R., Lazzaro, G., Constantinou, Andreas I., Guo, L.

Publikováno v: Journal of the National Cancer Institute
J.Natl.Cancer Inst.

Background: The form of vitamin D (vitamin D3) in fortified milk and the provitamin D produced by the body undergo metabolic activation to a biologically active form, 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3]. This compound can induce cell different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4485::5aec17ffe695acb9d16b2fd34fe3ec81
http://gnosis.library.ucy.ac.cy/handle/7/53247

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Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylasetissue plasminogen activator-mediated thrombolysis

Autor: Gerhäuser, C., Mar, W., Lee, S. K., Suh, N., Luo, Y., Kosmeder, J., Luyengi, L., Fong, H. H. S., Kinghorn, A. D., Moriarty, R. M., Mehta, R. G., Constantinou, Andreas I., Moon, R. C., Pezzuto, J. M.

Publikováno v: Nature medicine
Nat.Med.

For the discovery of new cancer chemopreventive agents, we have studied the potential of plant extracts to inhibit phorbol ester-induced ornithine decarboxylase (ODC) activity in cell culture. Four active rotenoids were obtained from the African plan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4485::0fc38d845f3d95d09d5f22339570cbac
http://gnosis.library.ucy.ac.cy/handle/7/53104

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Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage

Autor: Mehta, R. G., Liu, J., Constantinou, Andreas I., Thomas, C. F., Hawthorne, M., You, M., Gerhäuser, C., Pezzuto, J. M., Moon, R. C., Moriarty, R. M.

Publikováno v: Carcinogenesis

Brassinin [3-(S-methyldithiocarbamoyl aminomethyl indole], a phytoalexin first identified as a constituent of cabbage, was synthesized and evaluated for cancer chemopreventive activity. Dose-dependent inhibition of 7,12-dimethylbenz [a]anthracene (DM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c579d9084aff3d096d9da445f838bbdf
http://gnosis.library.ucy.ac.cy/handle/7/53245

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Structure-activity relationships of brassinin in preventing the development of carcinogen-induced mammary lesions in organ culture

Autor: Mehta, R. G., Liu, J., Constantinou, Andreas I., Hawthorne, M., Pezzuto, J. M., Moon, R. C., Moriarty, R. M.

Publikováno v: Anticancer Research
Anticancer Res.

Brassinin, a pkytoalexin, is found in Chinese cabbage. Previously, we showed that brassinin significantly inhibited dimethylbenz(a)anthracene (DMBA)-induced mammary lesions in organ culture. Moreover, it was an effective inhibitor against two stage s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4485::87053bd17275b8ed5e98e01de007d57c
http://gnosis.library.ucy.ac.cy/handle/7/53244

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