Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Moriak Monica Helen"'
Autor:
Michele Tsang, Christopher Pargellis, Alan David Swinamer, Rajiv Sharma, Kirrane Thomas M, Kevin Chungeng Qian, Pier F. Cirillo, Carol A. Torcellini, Matthew R. Netherton, Zhaoming Xiong, Neil Moss, Rachel R. Kroe, Eugene R. Hickey, Usha R. Patel, Steffen Breitfelder, Jeffrey B. Madwed, Faith Corbo Gaenzler, Daniel R. Goldberg, Sanxing Sun, Moriak Monica Helen, Victor Marc Kamhi, Hidenori Takahashi, Tazmeen N. Fadra, Gilmore Thomas A, Raj Betageri
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(9)
An effort aimed at exploring structural diversity in the N-pyrazole-N′-naphthylurea class of p38 kinase inhibitors led to the synthesis and characterization of N-phenyl-N′-naphthylureas. Examples of these compounds displayed excellent inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59cd06394b4e5ed174828058be6d3172
https://pubmed.ncbi.nlm.nih.gov/19356929
https://pubmed.ncbi.nlm.nih.gov/19356929
Autor:
Neil Moss, John R. Regan, Pier F. Cirillo, Moriak Monica Helen, Alan David Swinamer, Liang Tong, Carol A. Torcellini, Eugene R. Hickey, Alfred Proto, Gilmore Thomas A, Bernhard Klaus, Jeffrey B. Madwed, Sue Pav, Steffen Breitfelder, Chris Pargellis, A. G. Graham
Publikováno v:
Journal of medicinal chemistry. 45(14)
We report on a series of N-pyrazole, N'-aryl ureas and their mode of binding to p38 mitogen activated protein kinase. Importantly, a key binding domain that is distinct from the adenosine 5'-triphoshate (ATP) binding site is exposed when the conserve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b5969b08e99078038a78743ae25333
https://pubmed.ncbi.nlm.nih.gov/12086485
https://pubmed.ncbi.nlm.nih.gov/12086485