1,3-Dichloroadamantyl-Containing Ureas as Potential Triple Inhibitors of Soluble Epoxide Hydrolase, p38 MAPK and c-Raf.

Autor: Gladkikh, Boris P.¹ (AUTHOR) gladkih-boris@mail.ru, Danilov, Dmitry V.¹ (AUTHOR) danilov.dmitry.vlz@yandex.ru, D'yachenko, Vladimir S.^1,2 (AUTHOR) gmbutov@mail.ru, Butov, Gennady M.^1,2 (AUTHOR)

Publikováno v: International Journal of Molecular Sciences. Jan2024, Vol. 25 Issue 1, p338. 29p.

Structure−Activity Relationships of the p38α MAP Kinase Inhibitor 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796)

Autor: Regan, J., Capolino, A., Cirillo, P. F., Gilmore, T., Graham, A. G., Hickey, E., Kroe, R. R., Madwed, J., Moriak, M., Nelson, R., Pargellis, C. A., Swinamer, A., Torcellini, C., Tsang, M., Moss, N.

Publikováno v: Journal of Medicinal Chemistry; October 2003, Vol. 46 Issue: 22 p4676-4686, 11p

The Importance of the Pyrazole Scaffold in the Design of Protein Kinases Inhibitors as Targeted Anticancer Therapies.

Autor: Nitulescu, George Mihai¹ (AUTHOR) george.nitulescu@umfcd.ro, Stancov, Gheorghe¹ (AUTHOR), Seremet, Oana Cristina¹ (AUTHOR), Nitulescu, Georgiana¹ (AUTHOR) georgiana.nitulescu@umfcd.ro, Mihai, Dragos Paul¹ (AUTHOR), Duta-Bratu, Cosmina Gabriela¹ (AUTHOR), Barbuceanu, Stefania Felicia¹ (AUTHOR), Olaru, Octavian Tudorel¹ (AUTHOR)

Publikováno v: Molecules. Jul2023, Vol. 28 Issue 14, p5359. 32p.

Discovery and characterization of the N-phenyl-N'-naphthylurea class of p38 kinase inhibitors.

Autor: Cirillo PF; Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceutical, Inc., 900 Ridgebury Road, Ridgefield, CT 06877, USA., Hickey ER, Moss N, Breitfelder S, Betageri R, Fadra T, Gaenzler F, Gilmore T, Goldberg DR, Kamhi V, Kirrane T, Kroe RR, Madwed J, Moriak M, Netherton M, Pargellis CA, Patel UR, Qian KC, Sharma R, Sun S, Swinamer A, Torcellini C, Takahashi H, Tsang M, Xiong Z

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 May 01; Vol. 19 (9), pp. 2386-91. Date of Electronic Publication: 2009 Mar 26.

T3P^® facilitated one pot multicomponent reaction comprising unique intra-molecular rearrangement.

Autor: Shamanth, Sadashivamurthy¹ (AUTHOR), C. Sandhya, Nagarakere² (AUTHOR), Narayana, Yatheesh¹ (AUTHOR), Makanahalli P, Sunilkumar¹ (AUTHOR), Mamatha, Mahesha³ (AUTHOR), S. Rangappa, Kanchugarakoppal¹ (AUTHOR), Kempegowda, Mantelingu¹ (AUTHOR)

Publikováno v: Synthetic Communications. 2022, Vol. 52 Issue 8, p1122-1130. 9p. 4 Diagrams, 3 Charts.