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Targeting TGFβR2‐mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer
Autor:
Huocong Huang, Yuqing Zhang, Valerie Gallegos, Noah Sorrelle, Mohamed Medhat Zaid, Jason Toombs, Wenting Du, Steven Wright, Moriah Hagopian, Zhaoning Wang, Abdel Nasser Hosein, Adwait Amod Sathe, Chao Xing, Eugene J Koay, Kyla E Driscoll, Rolf A Brekken
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 11, Pp 1-20 (2019)
Abstract TGFβ is important during pancreatic ductal adenocarcinoma (PDA) progression. Canonical TGFβ signaling suppresses epithelial pancreatic cancer cell proliferation; as a result, inhibiting TGFβ has not been successful in PDA. In contrast, we
Externí odkaz:
https://doaj.org/article/7541d711b35f4c639b31ee32955e251b
