Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Morgillo CM"'
1
Combined FAAH and COX inhibition by Flurbiprofen amide derivatives for the treatment of pain and inflammation
Autor: Moraca F, Morgillo CM, Deplano A, Novellino E, Onnis V, Fowler CJ, Catalanotti B
Nonsteroidal anti‐inflammatory drugs (NSAIDs) – such as ibuprofen and flurbiprofen – are non-selective COX inhibitors widely used to treat acute and chronic pain. Several studies have indicated that the analgesic effect of NSAIDs is enhanced wh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::34271a9d539e1fd85656b0d7c2cceb3e
http://hdl.handle.net/11588/821107
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2
Design and pharmacological evaluation of Ibuprofen amides derivatives as dual FAAH/COX inhibitors
Autor: Moraca F, Morgillo CM, Deplano A, Novellino E, Onnis V, Fowler CJ, Catalanotti B
Fatty acid amide hydrolase (FAAH) is a serine hydrolase enzyme responsible of the hydrolytic degradation of N-acylethanolamine endocannabinoids, such as the Arachidonoylethanolamide (anandamide, AEA), which it has been shown to alleviate pain and inf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::56c72a5b506fddf8c077fee30d5539a7
http://hdl.handle.net/11588/821091
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3
Akademický článek
Exploring the DNA 2 -PNA heterotriplex formation in targeting the Bcl-2 gene promoter: A structural insight by physico-chemical and microsecond-scale MD investigation.
Autor: Falanga AP; Dipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Naples, 80131, Italy., Lupia A; Dipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Naples, 80131, Italy., Tripodi L; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università Degli Studi di Napoli Federico II, Naples, 80131, Italy.; CEINGE-Biotecnologie Avanzate Franco Salvatore S.c.a.r.l., Naples, 80145, Italy., Morgillo CM; Dipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Naples, 80131, Italy., Moraca F; Dipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Naples, 80131, Italy., Roviello GN; Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale Delle Ricerche, Naples, 80131, Italy., Catalanotti B; Dipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Naples, 80131, Italy., Amato J; Dipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Naples, 80131, Italy., Pastore L; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università Degli Studi di Napoli Federico II, Naples, 80131, Italy.; CEINGE-Biotecnologie Avanzate Franco Salvatore S.c.a.r.l., Naples, 80145, Italy., Cerullo V; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università Degli Studi di Napoli Federico II, Naples, 80131, Italy.; ImmunoViroTherapy Lab (IVT), Drug Research Program (DRP), Faculty of Pharmacy, University of Helsinki, 00100, Helsinki, Finland., D'Errico S; Dipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Naples, 80131, Italy., Piccialli G; Dipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Naples, 80131, Italy., Oliviero G; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università Degli Studi di Napoli Federico II, Naples, 80131, Italy., Borbone N; Dipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Naples, 80131, Italy.
Publikováno v: Heliyon [Heliyon] 2024 Jan 22; Vol. 10 (3), pp. e24599. Date of Electronic Publication: 2024 Jan 22 (Print Publication: 2024).
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4
Akademický článek
Molecular Basis for Non-Covalent, Non-Competitive FAAH Inhibition.
Autor: Morgillo CM; Department of Pharmacy, University of Naples 'Federico II', Via D. Montesano 49, 80131 Naples, Italy., Lupia A; Department of Pharmacy, University of Naples 'Federico II', Via D. Montesano 49, 80131 Naples, Italy.; Net4Science srl, University 'Magna Græcia' of Catanzaro, Campus Salvatore Venuta, Viale Europa, 88100 Catanzaro, Italy., Deplano A; Department of Life and Environmental Sciences, Unit of Pharmaceutical, Pharmacological and Nutraceutical Sciences, University of Cagliari, 09042 Monserrato, Italy., Pirone L; Institute of Biostructures and Bioimaging, CNR, 80131 Naples, Italy., Fiorillo B; Department of Pharmacy, University of Naples 'Federico II', Via D. Montesano 49, 80131 Naples, Italy., Pedone E; Institute of Biostructures and Bioimaging, CNR, 80131 Naples, Italy., Luque FJ; Department of Nutrition, Food Science and Gastronomy, Faculty of Pharmacy and Food Sciences, Institute of Biomedicine (IBUB), and Institute of Theoretical and Computational Chemistry (IQTC), University of Barcelona, E-08921 Santa Coloma de Gramenet, Spain., Onnis V; Department of Life and Environmental Sciences, Unit of Pharmaceutical, Pharmacological and Nutraceutical Sciences, University of Cagliari, 09042 Monserrato, Italy., Moraca F; Department of Pharmacy, University of Naples 'Federico II', Via D. Montesano 49, 80131 Naples, Italy.; Net4Science srl, University 'Magna Græcia' of Catanzaro, Campus Salvatore Venuta, Viale Europa, 88100 Catanzaro, Italy., Catalanotti B; Department of Pharmacy, University of Naples 'Federico II', Via D. Montesano 49, 80131 Naples, Italy.
Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Dec 07; Vol. 23 (24). Date of Electronic Publication: 2022 Dec 07.
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5
Akademický článek
Design, synthesis and in vitro and in vivo biological evaluation of flurbiprofen amides as new fatty acid amide hydrolase/cyclooxygenase-2 dual inhibitory potential analgesic agents.
Autor: Deplano A; Unit of Pharmaceutical, Pharmacological and Nutraceutical Sciences, Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy., Karlsson J; Department of Integrative Medical Biology, Umeå University, Umeå, Sweden., Moraca F; Department of Pharmacy, University of Naples Federico II, Naples, Italy.; Net4Science srl, University 'Magna Graecia', Catanzaro, Italy., Svensson M; Department of Integrative Medical Biology, Umeå University, Umeå, Sweden., Cristiano C; Department of Pharmacy, University of Naples Federico II, Naples, Italy., Morgillo CM; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, UK., Fowler CJ; Department of Integrative Medical Biology, Umeå University, Umeå, Sweden., Russo R; Department of Pharmacy, University of Naples Federico II, Naples, Italy., Catalanotti B; Department of Pharmacy, University of Naples Federico II, Naples, Italy., Onnis V; Unit of Pharmaceutical, Pharmacological and Nutraceutical Sciences, Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
Publikováno v: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 940-953.
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6
Akademický článek
Novel propanamides as fatty acid amide hydrolase inhibitors.
Autor: Deplano A; Department of Life and Environmental Sciences, Unit of Pharmaceutical, Pharmacological and Nutraceutical Sciences, University of Cagliari, via Ospedale 72, Cagliari I-09124, Italy., Morgillo CM; Department of Pharmacy, Università Degli Studi di Napoli Federico II, Napoli, Italy., Demurtas M; Department of Life and Environmental Sciences, Unit of Pharmaceutical, Pharmacological and Nutraceutical Sciences, University of Cagliari, via Ospedale 72, Cagliari I-09124, Italy., Björklund E; Department of Pharmacology and Clinical Neuroscience, Umeå University, SE-901 87 Umeå, Sweden., Cipriano M; Department of Pharmacology and Clinical Neuroscience, Umeå University, SE-901 87 Umeå, Sweden., Svensson M; Department of Pharmacology and Clinical Neuroscience, Umeå University, SE-901 87 Umeå, Sweden., Hashemian S; Department of Pharmacology and Clinical Neuroscience, Umeå University, SE-901 87 Umeå, Sweden., Smaldone G; IRCCS SDN, Via Emanuele Gianturco 113, 80143 Napoli, Italy., Pedone E; Institute of Biostructures and Bioimaging, CNR, Naples, Italy., Luque FJ; Departament de Nutrició, Ciències de l'Alimentació i Gastronomia and Institut de Biomedicina (IBUB), Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Santa Coloma de Gramenet, Spain., Cabiddu MG; Department of Chemical and Geological Sciences, University of Cagliari, Italy., Novellino E; Department of Pharmacy, Università Degli Studi di Napoli Federico II, Napoli, Italy., Fowler CJ; Department of Pharmacology and Clinical Neuroscience, Umeå University, SE-901 87 Umeå, Sweden., Catalanotti B; Department of Pharmacy, Università Degli Studi di Napoli Federico II, Napoli, Italy. Electronic address: brucatal@unina.it., Onnis V; Department of Life and Environmental Sciences, Unit of Pharmaceutical, Pharmacological and Nutraceutical Sciences, University of Cagliari, via Ospedale 72, Cagliari I-09124, Italy.
Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2017 Aug 18; Vol. 136, pp. 523-542. Date of Electronic Publication: 2017 May 12.
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7
Akademický článek
Peptide Nucleic Acids as miRNA Target Protectors for the Treatment of Cystic Fibrosis.
Autor: Zarrilli F; Department of Biosciences and Territory, University of Molise, 86170 Isernia, Italy. zarrillif@gmail.com.; CEINGE-Advanced Biotechnologies Scarl, 80131 Napoli, Italy. zarrillif@gmail.com., Amato F; CEINGE-Advanced Biotechnologies Scarl, 80131 Napoli, Italy. felice.amato@unina.it.; Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Napoli, Italy. felice.amato@unina.it., Morgillo CM; Department of Pharmacy, University of Naples Federico II, 80131 Napoli, Italy. giuseppe.castaldo@unina.it., Pinto B; Department of Pharmacy, University of Naples Federico II, 80131 Napoli, Italy. carminemarco.morgillo@unina.it., Santarpia G; Department of Pharmacy, University of Naples Federico II, 80131 Napoli, Italy. brunella.pinto87@gmail.com., Borbone N; Department of Pharmacy, University of Naples Federico II, 80131 Napoli, Italy. santarpiagiuliano@gmail.com., D'Errico S; Department of Pharmacy, University of Naples Federico II, 80131 Napoli, Italy. nicola.borbone@unina.it., Catalanotti B; Department of Pharmacy, University of Naples Federico II, 80131 Napoli, Italy. stefano.derrico@unina.it., Piccialli G; Department of Pharmacy, University of Naples Federico II, 80131 Napoli, Italy. brucatal@unina.it., Castaldo G; CEINGE-Advanced Biotechnologies Scarl, 80131 Napoli, Italy. picciall@unina.it.; Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Napoli, Italy. picciall@unina.it., Oliviero G; Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Napoli, Italy. golivier@unina.it.
Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2017 Jul 08; Vol. 22 (7). Date of Electronic Publication: 2017 Jul 08.
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8
Akademický článek
Interaction of the N-(3-Methylpyridin-2-yl)amide Derivatives of Flurbiprofen and Ibuprofen with FAAH: Enantiomeric Selectivity and Binding Mode.
Autor: Karlsson J; Department of Pharmacology and Clinical Neuroscience, Pharmacology Unit, Umeå University, Umeå, Sweden., Morgillo CM; Department of Pharmacy, Università degli Studi di Napoli Federico II, Napoli, Italy., Deplano A; Department of Life and Environmental Sciences, Unit of Pharmaceutical, Pharmacological and Nutraceutical Sciences, University of Cagliari, via Ospedale 72, Cagliari, I-09124, Italy., Smaldone G; Institute of Biostructures and Bioimaging, CNR, Naples, Italy., Pedone E; Institute of Biostructures and Bioimaging, CNR, Naples, Italy., Luque FJ; Departament de Fisicoquímica and Institut de Biomedicina (IBUB), Facultat de Farmàcia, Universitat de Barcelona, Santa Coloma de Gramenet, Spain., Svensson M; Department of Pharmacology and Clinical Neuroscience, Pharmacology Unit, Umeå University, Umeå, Sweden., Novellino E; Department of Pharmacy, Università degli Studi di Napoli Federico II, Napoli, Italy., Congiu C; Department of Life and Environmental Sciences, Unit of Pharmaceutical, Pharmacological and Nutraceutical Sciences, University of Cagliari, via Ospedale 72, Cagliari, I-09124, Italy., Onnis V; Department of Life and Environmental Sciences, Unit of Pharmaceutical, Pharmacological and Nutraceutical Sciences, University of Cagliari, via Ospedale 72, Cagliari, I-09124, Italy., Catalanotti B; Department of Pharmacy, Università degli Studi di Napoli Federico II, Napoli, Italy., Fowler CJ; Department of Pharmacology and Clinical Neuroscience, Pharmacology Unit, Umeå University, Umeå, Sweden.
Publikováno v: PloS one [PLoS One] 2015 Nov 13; Vol. 10 (11), pp. e0142711. Date of Electronic Publication: 2015 Nov 13 (Print Publication: 2015).
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9
Akademický článek
Structural model of the hUbA1-UbcH10 quaternary complex: in silico and experimental analysis of the protein-protein interactions between E1, E2 and ubiquitin.
Autor: Correale S; Kedrion S.p.A., Sant 'Antimo (Na), Italy., de Paola I; Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Napoli, Italy., Morgillo CM; Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Napoli, Italy., Federico A; Istituto di Endocrinologia ed Oncologia Sperimentale Consiglio Nazionale delle Ricerche, Napoli, Italy., Zaccaro L; Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Napoli, Italy., Pallante P; Istituto di Endocrinologia ed Oncologia Sperimentale Consiglio Nazionale delle Ricerche, Napoli, Italy., Galeone A; Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Napoli, Italy., Fusco A; Istituto di Endocrinologia ed Oncologia Sperimentale Consiglio Nazionale delle Ricerche, Napoli, Italy., Pedone E; Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Napoli, Italy., Luque FJ; Departament de Fisicoquímica and Institut de Biomedicina (IBUB), Facultat de Farmàcia, Universitat de Barcelona, Santa Coloma de Gramenet, Spain., Catalanotti B; Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Napoli, Italy.
Publikováno v: PloS one [PLoS One] 2014 Nov 06; Vol. 9 (11), pp. e112082. Date of Electronic Publication: 2014 Nov 06 (Print Publication: 2014).
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10
Akademický článek
Exploitation of a very small peptide nucleic acid as a new inhibitor of miR-509-3p involved in the regulation of cystic fibrosis disease-gene expression.
Autor: Amato F; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Via Pansini 5, 80131 Napoli, Italy ; CEINGE-Biotecnologie Avanzate, 80131 Napoli, Italy., Tomaiuolo R; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Via Pansini 5, 80131 Napoli, Italy ; CEINGE-Biotecnologie Avanzate, 80131 Napoli, Italy., Nici F; Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy., Borbone N; Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy., Elce A; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Via Pansini 5, 80131 Napoli, Italy ; CEINGE-Biotecnologie Avanzate, 80131 Napoli, Italy ; Università Telematica Pegaso, 80143 Napoli, Italy., Catalanotti B; Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy., D'Errico S; Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy., Morgillo CM; Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy., De Rosa G; Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy., Mayol L; Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy., Piccialli G; Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy., Oliviero G; Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy., Castaldo G; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Via Pansini 5, 80131 Napoli, Italy ; CEINGE-Biotecnologie Avanzate, 80131 Napoli, Italy.
Publikováno v: BioMed research international [Biomed Res Int] 2014; Vol. 2014, pp. 610718. Date of Electronic Publication: 2014 Apr 15.
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