A Multimodal Omics Exploration of the Motor and Non-Motor Symptoms of Parkinson’s Disease

Autor: François-Xavier Lejeune, Farid Ichou, Etienne Camenen, Benoit Colsch, Florence Mauger, Caroline Peltier, Ivan Moszer, Emmanuel Gilson, Morgane Pierre-Jean, Edith Le Floch, Victor Sabarly, Arthur Tenenhaus, Jean-François Deleuze, Claire Ewenczyk, Marie Vidailhet, Fanny Mochel

Publikováno v: International Journal of Translational Medicine, Vol 2, Iss 1, Pp 97-112 (2022)

Parkinson’s disease (PD) is the second most common neurodegenerative disease clinically characterized by classical motor symptoms and a range of associated non-motor symptoms. Due to the heterogeneity of symptoms and variability in patient prognosi

Externí odkaz: https://doaj.org/article/e849da5d84614d95817ed83589da9e1f

Exploring the Link Between Additive Heritability and Prediction Accuracy From a Ridge Regression Perspective

Autor: Arthur Frouin, Claire Dandine-Roulland, Morgane Pierre-Jean, Jean-François Deleuze, Christophe Ambroise, Edith Le Floch

Publikováno v: Frontiers in Genetics, Vol 11 (2020)

Genome-Wide Association Studies (GWAS) explain only a small fraction of heritability for most complex human phenotypes. Genomic heritability estimates the variance explained by the SNPs on the whole genome using mixed models and accounts for the many

Externí odkaz: https://doaj.org/article/3a3bdae5ce1f4e90a246e83aef1cf973

Leveraging Clinical Data Warehouses to Measure Impact of Update Prescription Guidelines of Polyvalent Immunoglobulins in 2018 in France

Autor: Morgane Pierre-Jean, Guillaume Bouzille, Mathilde Bories, Pascal Le Corre, Marc Cuggia

Publikováno v: Caring is Sharing – Exploiting the Value in Data for Health and Innovation ISBN: 9781643683881

In France and in other countries, we observed a significant growth in human polyvalent immunoglobulins (PvIg) usage. PvIg is manufactured from plasma collected from numeral donors, and its production is complex. Supply tensions have been observed for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4d0ea04bc769de1604153ae14f655b2
https://doi.org/10.3233/shti230131

Dissemination patterns of Hodgkin lymphoma using a probability network model based on [

Autor: Mehdi, Mouheb, Morgane, Pierre-Jean, Christophe, Fermé, Anne, Devillers, Thierry, Lamy, Florence, Le Jeune, Roch, Houot, Xavier, Palard-Novello

Publikováno v: European journal of nuclear medicine and molecular imaging.

The preferred hypothesis for the dissemination patterns of Hodgkin lymphoma (HL) is the contiguity hypothesis. However, this hypothesis is based on studies performed before the advent of [We retrospectively analyzed [A total of 196 patients were incl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::952a265c7c349a3f7ebb955757ca3055
https://pubmed.ncbi.nlm.nih.gov/36522437

New efficient algorithms for multiple change-point detection with reproducing kernels

Autor: Guillem Rigaill, Guillemette Marot, Alain Celisse, Morgane Pierre-Jean

Publikováno v: Computational Statistics and Data Analysis
Computational Statistics and Data Analysis, Elsevier, 2018, 128, pp.200-220. ⟨10.1016/j.csda.2018.07.002⟩
Computational Statistics and Data Analysis, 2018, 128, pp.200-220. ⟨10.1016/j.csda.2018.07.002⟩

Several statistical approaches based on reproducing kernels have been proposed to detect abrupt changes arising in the full distribution of the observations and not only in the mean or variance. Some of these approaches enjoy good statistical propert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c108fb9a87ef0df00442fce53364d14
https://doi.org/10.1016/j.csda.2018.07.002