Levels of Receptor for Advanced Glycation End Products and Glyoxalase-1 in the Total Circulating Extracellular Vesicles from Mild Cognitive Impairment and Different Stages of Alzheimer’s Disease Patients

Autor: Charles Ramassamy, Tamas Fulop, Morgane Perrotte, Mohamed Raâfet Ben Khedher, Aurelie Lepage, Elise Madec, Mohamed Haddad

Publikováno v: Journal of Alzheimer's Disease. 84:227-237

Background: Growing evidence supports that receptor for advanced glycation end products (RAGE) and glyoxalase-1 (GLO-1) are implicated in the pathophysiology of Alzheimer’s disease (AD). Extracellular vesicles (EVs) are nanovesicles secreted by alm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525b135f71e0ca6a50a1f6340132236f
https://doi.org/10.3233/jad-210441

An updated model of hydrocephalus in sheep to evaluate the performance of a device for ambulatory wireless monitoring of cerebral pressure through shunts

Autor: Palma P Sistiaga, Thomas Metayer, Evelyne Emery, Morgane Perrotte, Denis Vivien, Christophe Isnard, Thomas Gaberel, Romaric Saulnier, Philippe Auvray, Laurent Chazalviel, Johan Lazardeux

Publikováno v: Neuro-Chirurgie. 68(3)

Background: Cerebrospinal fluid (CSF) diversion by shunts is the most common surgical treatment for hydrocephalus. Though effective, shunts are associated with risk of dysfunction leading to multiple surgical revisions, affecting patient quality-of-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ddb9d08bf2712bf761aa37050227e7b
https://pubmed.ncbi.nlm.nih.gov/34774581

Methylglyoxal and Glyoxal as Potential Peripheral Markers for MCI Diagnosis and Their Effects on the Expression of Neurotrophic, Inflammatory and Neurodegenerative Factors in Neurons and in Neuronal Derived-Extracellular Vesicles

Autor: Mohamed Raâfet Ben Khedher, Morgane Perrotte, Tamas Fulop, Mohamed Haddad, Aurelie Lepage, Charles Ramassamy, Clément Demongin

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 19, p 4906 (2019)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2019, 20 (19), pp.4906. ⟨10.3390/ijms20194906⟩
Volume 20
Issue 19

Methylglyoxal (MG) and glyoxal (GO) are suggested to be associated with the development of neurodegenerative pathologies. However, their peripheral levels in relation to cognitive decline and their effects on key factors in neuronal cells are poorly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4386cc422928baa33a67f1b52d75bc7d
https://www.mdpi.com/1422-0067/20/19/4906

Circulating and Extracellular Vesicles Levels of N-(1-Carboxymethyl)-L-Lysine (CML) Differentiate Early to Moderate Alzheimer's Disease

Autor: Morgane Perrotte, Charles Ramassamy, Sarra Landri, Tamas Fulop, Aurelie Lepage, Mohamed Haddad

Publikováno v: Journal of Alzheimer's Disease
Journal of Alzheimer's Disease, IOS Press, 2019, 69 (3), pp.751-762. ⟨10.3233/JAD-181272⟩

Background Both advanced glycation end products (AGEs) N-(1-carboxymethyl)-L-lysine (CML) and pentosidine were found in the brain from Alzheimer's disease (AD) patients and were associated with the neuropathological hallmarks of AD. In AD patients, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4bdd43dd95eb902264f3299e5213cd2
https://pubmed.ncbi.nlm.nih.gov/31127773

Cerebral Apolipoprotein D Exits the Brain and Accumulates in Peripheral Tissues

Autor: Guillaume Fyfe-Desmarais, Catherine Mounier, Karl-F. Bergeron, Vincent Hervé, Frederik Desmarais, Eric Rassart, Morgane Perrotte, Charles Ramassamy, Gaetan Ravaut

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 4118, p 4118 (2021)

Apolipoprotein D (ApoD) is a secreted lipocalin associated with neuroprotection and lipid metabolism. In rodent, the bulk of its expression occurs in the central nervous system. Despite this, ApoD has profound effects in peripheral tissues, indicatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354d08146107851203920c06cb0e105a
https://doi.org/10.3390/ijms22084118