Výsledky vyhledávání - "Morgane Louessard"

Akademický článek

Huntingtin lowering impairs the maturation and synchronized synaptic activity of human cortical neuronal networks derived from induced pluripotent stem cells

Autor: Mathilde Louçã, Donya El Akrouti, Aude Lemesle, Morgane Louessard, Noëlle Dufour, Chloé Baroin, Aurore de la Fouchardière, Laurent Cotter, Hélène Jean-Jacques, Virginie Redeker, Anselme L. Perrier

Publikováno v: Neurobiology of Disease, Vol 200, Iss , Pp 106630- (2024)

Despite growing descriptions of wild-type Huntingtin (wt-HTT) roles in both adult brain function and, more recently, development, several clinical trials are exploring HTT-lowering approaches that target both wt-HTT and the mutant isoform (mut-HTT) r

Externí odkaz: https://doaj.org/article/014f66c687ef4b789460f73ea00cc84e

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Akademický článek

CTIP2-Regulated Reduction in PKA-Dependent DARPP32 Phosphorylation in Human Medium Spiny Neurons: Implications for Huntington Disease

Autor: Marija Fjodorova, Morgane Louessard, Zongze Li, Daniel C. De La Fuente, Emma Dyke, Simon P. Brooks, Anselme L. Perrier, Meng Li

Publikováno v: Stem Cell Reports, Vol 13, Iss 3, Pp 448-457 (2019)

Summary: The mechanisms underlying the selective degeneration of medium spiny neurons (MSNs) in Huntington disease (HD) remain largely unknown. CTIP2, a transcription factor expressed by all MSNs, is implicated in HD pathogenesis because of its inter

Externí odkaz: https://doaj.org/article/951ad28726b04624b556ebadd2e08d26

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I05 Increasing brain palmitoylation rescues behavior and neuropathology in huntington disease mice

Autor: Maria-Victoria Hinckelmann, Frédéric Saudou, Morgane Louessard, Rémi Carpentier, Sophie Lenoir, Patricia Lino, Aurélie Genoux, Sandrine Humbert, Laura Auboyer, Anselm Perrier, Chiara Scaramuzzino, Amandine Virlogeux

Publikováno v: I: Experimental therapeutics – preclinical.

Background Huntington Disease (HD) involves a complex cascade of pathogenic events, but central to its disruption of the cortico-striatal circuitry is impaired trafficking of Brain-Derived Neurotrophic Factor (BDNF). Aim We hypothesized that improvin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::639ab5cc70461b946f0608deb119d86f
https://doi.org/10.1136/jnnp-2021-ehdn.119

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Activation of cell surface GRP78 decreases endoplasmic reticulum stress and neuronal death

Autor: Cyrille Orset, Carine Ali, Valérie Carraro, Jérôme Parcq, Benoit D. Roussel, Isabelle Bardou, Audrey M Thiebaut, Anne Terrisse, Denis Vivien, Jérôme Leprince, Eloise Lemarchand, Morgane Louessard, Alain Bruhat, Pierre Fafournoux

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, 2017, 24 (9), pp.1518-1529. ⟨10.1038/cdd.2017.35⟩
Cell Death and Differentiation, Nature Publishing Group, 2017, 24 (9), pp.1518-1529. ⟨10.1038/cdd.2017.35⟩

This project was supported by the Region Basse-Normandie and the AXA postdoctoral fellowship program, the INSERM, and the university of Caen. We thank Mr Gilbert Pigree and Mr Maxime Lemarchand for their help with the production of radioactive tPA (I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41b5a9ee025acbac789d4acfd9c09f4
https://doi.org/10.1038/cdd.2017.35

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CTIP2-regulated reduction in PKA-dependent DARPP32 phosphorylation in human medium spiny neurons: \ud implications for Huntington’s disease

Autor: Emma Dyke, Zongze Li, Marija Fjodorova, Simon Philip Brooks, Morgane Louessard, Anselme L. Perrier, Meng Li, Daniel C. De La Fuente

Publikováno v: Stem Cell Reports, Vol 13, Iss 3, Pp 448-457 (2019)
Stem Cell Reports

Summary The mechanisms underlying the selective degeneration of medium spiny neurons (MSNs) in Huntington disease (HD) remain largely unknown. CTIP2, a transcription factor expressed by all MSNs, is implicated in HD pathogenesis because of its intera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fcd36be9ff2feb5ab560d79435a2f2
https://orca.cardiff.ac.uk/id/eprint/124505/3/1-s2.0-S221367111930267X-main.pdf

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B16 Astrocytes derived from patient specific human pluripotent stem cells: a valuable biological resource for target identification in hd?

Autor: Åsa Petersén, Johana Tournois, Marie Michael, Gilles Bonvento, Margot Jarrige, Anselme L. Perrier, Barbara Baldo, Morgane Louessard, Deniz Kirik, Gurvan Mahé, Julie Bigarreau

Publikováno v: Models for HD.

Several studies have outlined a non-cell-autonomous contribution in Huntington Disease (HD). Mutant-HTT (mut-HTT) expressed solely in astrocytes is sufficient for recapitulating the neurological and peripheral symptoms of HD in mice. Our objective is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::772be12a2880f3a012768aa0db789c45
https://doi.org/10.1136/jnnp-2018-ehdn.68

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A40 Modulation of DARPP32 homeostasis by htt protein in derivatives of disease-specific and control human pluripotent stem cells

Autor: Margot Jarrige, Julie Bigarreau, Gabriel Vachey, Morgane Louessard, Nicole Déglon, Anselme L. Perrier, Michel Cailleret

Publikováno v: Pathogenic mechanisms.

In Huntington disease (HD), the most affected cells are the GABA-releasing medium spiny neurons (MSN) of the striatum, the subcortical brain structure that controls body movement. DARPP32 (dopamine- and 3’,5’-cyclic adenosine monophosphate-regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5bb5bc10692aa7747ecb2218000dba9a
https://doi.org/10.1136/jnnp-2018-ehdn.38

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Tissue-Type Plasminogen Activator Controlled Corticogenesis Through a Mechanism Dependent of NMDA Receptors Expressed on Radial Glial Cells

Autor: Yannick Hommet, Morgane Louessard, Nolwenn Pasquet, Denis Vivien, Isabelle Bardou, Sara Douceau, Mickael Naveau, Flavie Lesept, Laurent Lebouvier

Publikováno v: Cerebral cortex (New York, N.Y. : 1991). 29(6)

Modifications of neuronal migration during development, including processes that control cortical lamination are associated with functional deficits at adult stage. Here, we report for the first time that the lack of the serine protease tissue-type P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aede9fc246087a8987cfd78d25458bc7
https://pubmed.ncbi.nlm.nih.gov/29878094

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Tissue Plasminogen Activator Expression Is Restricted to Subsets of Excitatory Pyramidal Glutamatergic Neurons

Autor: Eric Maubert, Alexandre Lacroix, Morgane Louessard, Bertrand Lambolez, Grégoire Mondielli, Denis Vivien, Bruno Cauli, Magalie Martineau, Jean-Pierre Mothet, Flavie Lesept, Axel Montagne

Publikováno v: Molecular Neurobiology
Molecular Neurobiology, Humana Press, 2016, 53 (7), pp.5000-5012. ⟨10.1007/s12035-015-9432-7⟩
Molecular Neurobiology, 2016, 53 (7), pp.5000-5012. ⟨10.1007/s12035-015-9432-7⟩

International audience; Although the extracellular serine protease tissue plasminogen activator (tPA) is involved in pathophysiological processes such as learning and memory, anxiety, epilepsy, stroke, and Alzheimer's disease, information about its r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c408032125c9621599d2d7dbfaf28c7f
https://doi.org/10.1007/s12035-015-9432-7

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