Výsledky vyhledávání - "Morgane Boulch"

Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity

Autor: Morgane Boulch, Marine Cazaux, Alexis Cuffel, Marion V. Guerin, Zacarias Garcia, Ruby Alonso, Fabrice Lemaître, Alexander Beer, Béatrice Corre, Laurie Menger, Capucine L. Grandjean, Florence Morin, Catherine Thieblemont, Sophie Caillat-Zucman, Philippe Bousso

Publikováno v: Nature Cancer
Nature Cancer, 2023, ⟨10.1038/s43018-023-00570-7⟩

CD4+ T cells and CD4+ chimeric antigen receptor (CAR) T cells display highly variable antitumor activity in preclinical models and in patients; however, the mechanisms dictating how and when CD4+ T cells promote tumor regression are incompletely unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee8211ffd4eb62019b8b82a7a399412
https://hal-pasteur.archives-ouvertes.fr/pasteur-04158305

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A crosstalk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity

Autor: Yann Loe-Mie, Philippe Bousso, Marine Cazaux, Zacarias Garcia, Fabrice Lemaître, Béatrice Corre, Capucine L. Grandjean, Ronan Thibaut, Morgane Boulch

Publikováno v: Science Immunology
Science Immunology, 2021, 6 (57), pp.eabd4344. ⟨10.1126/sciimmunol.abd4344⟩
Science Immunology, American Association for the Advancement of Science, 2021, 6 (57), pp.eabd4344. ⟨10.1126/sciimmunol.abd4344⟩

International audience; Chimeric antigen receptor (CAR) T cell therapy relies on the activity of a large pool of tumor-targeting cytotoxic effectors. Whether CAR T cells act autonomously or require interactions with the tumor microenvironment (TME) r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a3dcbad45018fd088202411a33008c
https://hal-pasteur.archives-ouvertes.fr/pasteur-03266252/document

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Is There a Place for Chimeric Antigen Receptor-T Cells in the Treatment of Chronic Autoimmune Rheumatic Diseases?

Autor: Yannick Allanore, Cindy Orvain, Jérôme Avouac, Philippe Bousso, Morgane Boulch

Publikováno v: Arthritisrheumatology (Hoboken, N.J.)References. 73(11)

Chimeric antigen receptor-T (CAR-T) cell therapy is based on specific targeting of tumor antigens, leading to lysis and destruction of tumor cells. The high potency of CAR-T cells in the management of B cell malignancies has been demonstrated. Follow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a423f402cfbb6617f3049512497087f9
https://pubmed.ncbi.nlm.nih.gov/34042325

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Neutrophil Swarming in Damaged Tissue Is Orchestrated by Connexins and Cooperative Calcium Alarm Signals

Autor: Morgane Boulch, Foteini Papaleonidopoulou, Antonios Georgantzoglou, Hazel A. Walker, Hugo Poplimont, Caroline Coombs, Milka Sarris

Summary Neutrophils are major inflammatory cells that rapidly infiltrate wounds to provide antimicrobial functions. Within the damaged tissue, neutrophil migration behavior often switches from exploratory patrolling to coordinated swarming, giving ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a31cf7811f55b5f1c0fae6c6856cf2c

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Neutrophil swarming in damaged tissue is orchestrated by connexin-dependent calcium signals

Autor: Foteini Papaleonidopoulou, Hugo Poplimont, Milka Sarris, Morgane Boulch, Caroline Coombs, Antonios Georgantzoglou

Neutrophils are major inflammatory cells that rapidly infiltrate injured tissues to provide antimicrobial functions. A key step in their response is the paracrine release of the attractant LTB4, which switches the migration mode from exploratory patr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5afad01aca55c492b9e5d547c01afb65
https://doi.org/10.1101/853093

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Tumor immunosurveillance and immunotherapies: a fresh look from intravital imaging

Autor: Morgane Boulch, Capucine L. Grandjean, Philippe Bousso, Marine Cazaux

Publikováno v: Trends in Immunology
Trends in Immunology, 2019, 40 (11), pp.1022-1034. ⟨10.1016/j.it.2019.09.002⟩
Trends in Immunology, Elsevier, 2019, 40 (11), pp.1022-1034. ⟨10.1016/j.it.2019.09.002⟩

International audience; Understanding complex interactions between the immune system and the tumor microenvironment is an essential step towards the rational development and optimization of immunotherapies. Several experimental approaches are availab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75743cdf4d27917f9130917adc3a92c
https://hal-pasteur.archives-ouvertes.fr/pasteur-02944694/document

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