Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Morgan V. Fedorchak"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The purpose of this study was to characterize and determine the efficacy of a long-term, non-invasive gel/microsphere (GMS) eye drop for glaucoma. This novel drug delivery system is comprised of a thermoresponsive hydrogel carrier and drug-l
Externí odkaz:
https://doaj.org/article/96ca231233a64b9c872534f82defeb1b
Publikováno v:
Drug Delivery and Translational Research. 11:2224-2238
Cystinosis is a rare, metabolic, recessive genetic disease in which the intralysosomal accumulation of cystine leads to system wide organ and tissue damage. In the eye, cystine accumulates in the cornea as corneal cystine crystals and severely impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee6118a4b6f0c6596cb7a9e5af6eb902
https://doi.org/10.1007/s13346-020-00890-6
https://doi.org/10.1007/s13346-020-00890-6
Publikováno v:
Drug Discovery Today. 24:1564-1574
As the field of ocular drug delivery grows so does the potential for novel drug discovery or reformulation in lesser-known diseases of the eye. In particular, rare corneal diseases are an interesting area of research because drug delivery is limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5720e6c0ac2b2eb6a5b5af71862b4f4
https://doi.org/10.1016/j.drudis.2019.03.005
https://doi.org/10.1016/j.drudis.2019.03.005
Publikováno v:
Drug delivery and translational researchReferences. 11(5)
Cystinosis is a rare, metabolic, recessive genetic disease in which the intralysosomal accumulation of cystine leads to system wide organ and tissue damage. In the eye, cystine accumulates in the cornea as corneal cystine crystals and severely impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::45b7f78cb83d2a56c6efe08e736adc1f
https://pubmed.ncbi.nlm.nih.gov/33543397
https://pubmed.ncbi.nlm.nih.gov/33543397
Autor:
Robert S. Parker, Jonathan E. Rubin, Thomas Rimmelé, Silvia Daun-Gruhn, Claudio Lagoa, John A. Kellum, Isabella E Valenti, Gilles Clermont, Morgan V. Fedorchak, Yoram Vodovotz, Justin Hogg, William J. Federspiel, Anirban Roy
Publikováno v:
Processes (Basel)
Processes, Vol 4, Iss 4, p 38 (2016)
Processes; Volume 4; Issue 4; Pages: 38
Processes 4(4), 38-(2016). doi:10.3390/pr4040038
Processes, Vol 4, Iss 4, p 38 (2016)
Processes; Volume 4; Issue 4; Pages: 38
Processes 4(4), 38-(2016). doi:10.3390/pr4040038
The body responds to endotoxins by triggering the acute inflammatory response system to eliminate the threat posed by gram-negative bacteria (endotoxin) and restore health. However, an uncontrolled inflammatory response can lead to tissue damage, org
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6221334c83ac353f48a02285c8e14fd4
https://pubmed.ncbi.nlm.nih.gov/33134139
https://pubmed.ncbi.nlm.nih.gov/33134139
Autor:
Liza A Bruk, Cuneyt M. Alper, Katherine E Dunkelberger, Pawjai Khampang, Wenzhou Hong, Srivatsun Sadagopan, Morgan V. Fedorchak
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 10, p e0240535 (2020)
PLoS ONE, Vol 15, Iss 10, p e0240535 (2020)
Acute otitis media (AOM) is the main indication for pediatric antibiotic prescriptions, accounting for 25% of prescriptions. While the use of topical drops can minimize the administered dose of antibiotic and adverse systemic effects compared to oral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69fa05cad9f5aa1e4a2781a1c1de4def
https://pubmed.ncbi.nlm.nih.gov/33045028
https://pubmed.ncbi.nlm.nih.gov/33045028
Autor:
Michael A. Washington, Tara Y. Meyer, Simon C. Watkins, Steven R. Little, Morgan V. Fedorchak, Stephen C. Balmert
Publikováno v:
Acta Biomaterialia. 65:259-271
Controlling the backbone architecture of poly(lactic-co-glycolic acid)s (PLGAs) is demonstrated to have a strong influence on the production and release of acidic degradation by-products in microparticle matrices. Previous efforts for controlling the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855c8c366577c0472f3581d3db8f364e
https://doi.org/10.1016/j.actbio.2017.10.043
https://doi.org/10.1016/j.actbio.2017.10.043
Low patient compliance and poor bioavailability of ophthalmic medications are the main limitations of topical eye drops. A potential solution to these disadvantages could be provided by thermoresponsive hydrogels, which could be used as the basis for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dee4bc3d06c57026ee52b2b459154ea
https://europepmc.org/articles/PMC6437675/
https://europepmc.org/articles/PMC6437675/
Publikováno v:
Journal of Controlled Release. 219:129-140
Bone regeneration is a complex process, that in vivo, requires the highly coordinated presentation of biochemical cues to promote the various stages of angiogenesis and osteogenesis. Taking inspiration from the natural healing process, a wide variety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351be891c02c5f11848c850238bee29c
https://doi.org/10.1016/j.jconrel.2015.08.004
https://doi.org/10.1016/j.jconrel.2015.08.004
Autor:
Riccardo Gottardi, Emily A. Bayer, Abhijit Roy, Jahnelle C. Jordan, Prashant N. Kumta, Steven R. Little, Morgan V. Fedorchak
Bone tissue engineering requires the upregulation of several regenerative stages, including a critical early phase of angiogenesis. Previous studies have suggested that a sequential delivery of platelet-derived growth factor (PDGF) to bone morphogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1ca1a2407ad15573e259846b30a1d3
https://europepmc.org/articles/PMC5729879/
https://europepmc.org/articles/PMC5729879/