Zobrazeno 1 - 4 of 4 pro vyhledávání: '"Morgan R. Zingsheim"'
1
Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors
Autor: Minying Cai, Johannes G. Beck, Udaya Kiran Marelli, Victor J. Hruby, Kaitlyn McLeod, Morgan R. Zingsheim, Florian Rechenmacher, Lucas Doedens, Florian Opperer, Jennifer Bao, Horst Kessler
Publikováno v: Journal of Medicinal Chemistry. 58:6359-6367
Human melanocortin receptors (hMCRs) have been challenging targets to develop ligands that are explicitly selective for each of their subtypes. To modulate the conformational preferences of the melanocortin ligands and improve the biofunctional agoni
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a1dd3ac9689b895972fe0a36163654
https://doi.org/10.1021/acs.jmedchem.5b00102
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3
Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor
Autor: Hongchang Qu, Minying Cai, Dev Trivedi, Victor J. Hruby, Alexander V. Mayorov, Morgan R. Zingsheim, Paolo Grieco
Publikováno v: Journal of medicinal chemistry. 52(12)
A new series of melanotropin analogues with His or Arg residues in the core pharmacophores of MTII, SHU9119, and Ac-NDP-gamma-MSH-NH(2) replaced by Pro or trans-/cis-4-guanidinyl-Pro derivatives were designed and synthesized to introduce selectivity
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c46702b9d0b0483110dba225c601e63
https://pubmed.ncbi.nlm.nih.gov/19473029
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Plný text Recenzováno Digitální knihovna AV ČR
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