Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Morgan R, Herod"'
Autor:
Eleni-Anna Loundras, James Streetley, Morgan R. Herod, Rebecca Thompson, Mark Harris, David Bhella, Nicola J. Stonehouse
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Loundras et al. report on the fibril components of the RNA-dependent RNA polymerase RdRp from foot-and-mouth disease virus. They demonstrate that higher-order fibril-based interactions create multiple complex structures within which RNA replication c
Externí odkaz:
https://doaj.org/article/fd0cabf965964352a52c576ea4715475
Autor:
Joseph C Ward, Lidia Lasecka-Dykes, Chris Neil, Oluwapelumi O Adeyemi, Sarah Gold, Niall McLean-Pell, Caroline Wright, Morgan R Herod, David Kealy, Emma Warner, Terry Jackson, Donald P King, Tobias J Tuthill, David J Rowlands, Nicola J Stonehouse
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010589 (2022)
Non-coding regions of viral RNA (vRNA) genomes are critically important in the regulation of gene expression. In particular, pseudoknot (PK) structures, which are present in a wide range of RNA molecules, have a variety of roles. The 5' untranslated
Externí odkaz:
https://doaj.org/article/8c98451b274449f58dae2fd9d06a9bcd
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 324:G415-G418
Diarrhea, often severe, is a recognized and frequently early symptom during acute COVID-19 infection and may persist or develop for the first time in patients with long-COVID, with socioeconomic consequences. Diarrheal mechanisms in these cases are p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::411611dc78c82bfe2a8a491a45fb6f1e
https://doi.org/10.1152/ajpgi.00021.2023
https://doi.org/10.1152/ajpgi.00021.2023
Autor:
Joseph S Snowden, Daniel L Hurdiss, Oluwapelumi O Adeyemi, Neil A Ranson, Morgan R Herod, Nicola J Stonehouse
Publikováno v:
PLoS Biology, Vol 18, Iss 3, p e3000649 (2020)
Icosahedral viral capsids must undergo conformational rearrangements to coordinate essential processes during the viral life cycle. Capturing such conformational flexibility has been technically challenging yet could be key for developing rational th
Externí odkaz:
https://doaj.org/article/9d3e1b9c3f2e493eb9f7b4ef1bc203d2
Publikováno v:
Journal of Virology. 97
Foot-and-mouth disease virus (FMDV) is responsible for foot-and-mouth disease (FMD), an important disease of farmed animals, which is endemic in many parts of the world and can results in major economic losses. Replication of the virus occurs within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f30048ceff262723d420e0c13537749
https://doi.org/10.1128/jvi.00171-23
https://doi.org/10.1128/jvi.00171-23
Autor:
Joseph C. Ward, Lidia Lasecka-Dykes, Samuel J. Dobson, Sarah Gold, Natalie J. Kingston, Morgan R. Herod, Donald P. King, Tobias Tuthill, David J. Rowlands, Nicola J. Stonehouse
Secondary and tertiary RNA structures play key roles in genome replication of single stranded positive sense RNA viruses. Complex, functional structures are particularly abundant in the untranslated regions of picornaviruses, where they are involved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6f647bf0a6890640376c9309f5cde36
https://doi.org/10.1101/2023.04.26.538422
https://doi.org/10.1101/2023.04.26.538422
Autor:
Jake T. Mills, Susanna C. Minogue, Joseph S. Snowden, Wynter K.C. Arden, David J. Rowlands, Nicola J. Stonehouse, Christiane E. Wobus, Morgan R. Herod
Publikováno v:
bioRxiv
Viruses interact with receptors on the cell surface to initiate and co-ordinate infection. The distribution of receptors on host cells can be a key determinant of viral tropism and host infection. Unravelling the complex nature of virus-receptor inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0248f9ff41366452b188f983fe434c80
https://europepmc.org/articles/PMC9949111/
https://europepmc.org/articles/PMC9949111/
Foot-and-mouth-disease virus (FMDV), the etiological agent responsible for foot-and-mouth disease (FMD), is a member of the genusAphthoviruswithin thePicornavirusfamily. In common with all picornaviruses, replication of the single-stranded positive-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3babe8dc3a72e696356c56c8c9f9c100
https://doi.org/10.1101/2023.01.20.524889
https://doi.org/10.1101/2023.01.20.524889
Hepatitis E virus (HEV) is an emerging pathogen responsible for more than 20 million cases of acute hepatitis globally per annum. Healthy individuals typically have a self-limiting infection, however, mortality rates in some populations such as pregn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ec5b5e03a406cf3edd6f7f9ee964dd2
https://doi.org/10.1101/2022.12.05.519105
https://doi.org/10.1101/2022.12.05.519105
Autor:
Danielle M. Pierce, Frazer J.T. Buchanan, Abigail Cox, Khadijah Abualsaoud, Joseph C. Ward, Mark Harris, Nicola J. Stonehouse, Morgan R. Herod
The genomes of positive-sense RNA viruses encode polyproteins that are essential for controlling viral replication. These viral polyproteins must undergo proteolysis (also termed polyprotein processing) to generate functional protein units. This prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::658fadd0f484962ec838d762c95e9cda
https://doi.org/10.1101/2022.12.05.519104
https://doi.org/10.1101/2022.12.05.519104