Internalized Functional DNA Aptamers as Alternative Cancer Therapies

Autor: Morgan L. Marshall, Kylie M. Wagstaff

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)

Despite major advances, cancer remains one of the largest burdens of disease worldwide. One reason behind this is that killing tumor cells without affecting healthy surrounding tissue remains a largely elusive prospect, despite the widespread availab

Externí odkaz: https://doaj.org/article/deafd2e6492645ac887c1ba558d5a159

Tumour-specific phosphorylation of serine 419 drives alpha-enolase (ENO1) nuclear export in triple negative breast cancer progression

Autor: Morgan L Marshall, Kim YC Fung, David A Jans, Kylie M Wagstaff

Publikováno v: Cell & Bioscience, Vol 14, Iss 1, Pp 1-22 (2024)

Abstract Background The glycolytic enzyme alpha-enolase is a known biomarker of many cancers and involved in tumorigenic functions unrelated to its key role in glycolysis. Here, we show that expression of alpha-enolase correlates with subcellular loc

Externí odkaz: https://doaj.org/article/ebc6ef5325644d92b45ceca6d5fe45d8

Myotubular myopathy and the neuromuscular junction: a novel therapeutic approach from mouse models

Autor: Andrew D. Snyder, Ashley N. Dulin-Smith, R. Joubert, Xingli Li, Alan H. Beggs, Christopher R. Pierson, Morgan L. Marshall, Sean E. Low, Anna Buj-Bello, Ashley N. Durban, Jordan T. Marshall, James J. Dowling, Nadia Messaddeq

Publikováno v: Disease Models & Mechanisms, Vol 5, Iss 6, Pp 852-859 (2012)
Disease Models & Mechanisms
Disease Models & Mechanisms, Cambridge Company of Biologists, 2012, 5 (6), pp.852-859. ⟨10.1242/DMM.009746⟩
Disease Models & Mechanisms, Cambridge Company of Biologists, 2012, 5 (6), pp.852-9. ⟨10.1242/dmm.009746⟩
Disease Models & Mechanisms, 2012, 5 (6), pp.852-9. ⟨10.1242/dmm.009746⟩
Disease Models & Mechanisms, 2012, 5 (6), pp.852-859. ⟨10.1242/DMM.009746⟩

Summary Myotubular myopathy (MTM) is a severe congenital muscle disease characterized by profound weakness, early respiratory failure and premature lethality. MTM is defined by muscle biopsy findings that include centralized nuclei and disorganizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60810bb1082a67fa47a6bf4f8658be3b
http://dmm.biologists.org/content/5/6/852