Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Morgan G, Stykel"'
Autor:
Jean-Louis A. Parmasad, Konrad M. Ricke, Benjamin Nguyen, Morgan G. Stykel, Brodie Buchner-Duby, Amanda Bruce, Haley M. Geertsma, Eric Lian, Nathalie A. Lengacher, Steve M. Callaghan, Alvin Joselin, Julianna J. Tomlinson, Michael G. Schlossmacher, William L. Stanford, Jiyan Ma, Patrik Brundin, Scott D. Ryan, Maxime W. C. Rousseaux
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-13 (2024)
Abstract Parkinson’s disease (PD) is a debilitating neurodegenerative disease characterized by the loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-Synuclein (α-Syn) protein. Currently, no treatment can slow nor hal
Externí odkaz:
https://doaj.org/article/3314777d4067426182b748c43099f849
Autor:
Morgan G. Stykel, Scott D. Ryan
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract Parkinson’s Disease (PD) is a neurodegenerative disorder characterized, in part, by the loss of dopaminergic neurons within the nigral-striatal pathway. Multiple lines of evidence support a role for reactive nitrogen species (RNS) in degen
Externí odkaz:
https://doaj.org/article/9b18ce2499c34dff8465e401a321e0d4
Overtraining Strengthens the Visual Discrimination Memory Trace Outside the Hippocampus in Male Rats
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2021)
The hippocampus (HPC) may compete with other memory systems when establishing a representation, a process termed overshadowing. However, this overshadowing may be mitigated by repeated learning episodes, making a memory resistant to post-training hip
Externí odkaz:
https://doaj.org/article/cadc8eab392e4d1e917fcf9986ec401a
Autor:
Morgan G. Stykel, Scott D. Ryan
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/5ab73da68732407fadb48cf35b1a3bee
Publikováno v:
J Neurosci
Cortical synucleinopathies, including dementia with Lewy bodies and Parkinson's disease dementia, collectively known as Lewy body dementia, are characterized by the aberrant aggregation of misfolded α-synuclein (α-syn) protein into large inclusions
Autor:
Tammy Ryan, Vladimir V. Bamm, Morgan G. Stykel, Carla L. Coackley, Kayla M. Humphries, Rhiannon Jamieson-Williams, Rajesh Ambasudhan, Dick D. Mosser, Stuart A. Lipton, George Harauz, Scott D. Ryan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Cardiolipin is a phospholipid component of the inner mitochondrial membrane. Here the authors demonstrate that cardiolipin interacts with mutant α-synuclein, and that impaired cardiolipin function can lead to spread of α-synuclein between neurons.
Externí odkaz:
https://doaj.org/article/0839cad1dc084b31b2fb1c7ae7cd4162
Autor:
Brodie Buchner-Duby, Jing X. Kang, Scott D. Ryan, David W.L. Ma, Jennifer Drolet, Morgan G. Stykel, Carla Coackley
Publikováno v:
Molecular Biology of the Cell
Evidence suggests that n-3 polyunsaturated fatty acids may act as activators of the Nrf2 antioxidant pathway. The antioxidant response, in turn, promotes neuronal differentiation and neurite outgrowth. Nrf2 has recently been suggested to be a cell in
Autor:
Anjali Balakrishnan, Morgan G Stykel, Yacine Touahri, Jo Anne Stratton, Jeff Biernaskie, Carol Schuurmans
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153256 (2016)
Schwann cells (SCs) arise from neural crest cells (NCCs) that first give rise to SC precursors (SCPs), followed by immature SCs, pro-myelinating SCs, and finally, non-myelinating or myelinating SCs. After nerve injury, mature SCs 'de-differentiate',
Externí odkaz:
https://doaj.org/article/7bea34c313c543d69c070e26e5de47de
Autor:
Ryan Hallam, Juliane Heide, Carla Coackley, Craig D.C. Bailey, Shalandra Wood, Tammy Ryan, Keith Sherriff, Morgan G. Stykel, Scott D. Ryan, Christopher Czaniecki, Jennifer Drolet
Publikováno v:
Proceedings of the National Academy of Sciences. 116:14280-14289
While mutations in the SNCA gene (α-synuclein [α-syn]) are causal in rare familial forms of Parkinson’s disease (PD), the prevalence of α-syn aggregates in the cortices of sporadic disease cases emphasizes the need to understand the link between
Autor:
Anjali Balakrishnan, Taylor Fleming, Lakshmy Vasan, Rajiv Midha, Lauren Belfiore, Carol Schuurmans, Yacine Touahri, Jeff Biernaskie, Morgan G. Stykel
Schwann cells are the principal glial cells of the peripheral nervous system, and their development into myelinating glia is critically dependent on MEK/ERK signaling. Ets-domain transcription factors (Etv1, Etv4, Etv5) are common downstream effector
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a6427c5cdc6776b7a73223a223bbd95
https://doi.org/10.1101/2020.09.23.309815
https://doi.org/10.1101/2020.09.23.309815