Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Morgan Fenn"'
Autor:
Yoshiaki Katsuda, Erin Bradley, Masato Noguchi, Masafumi Kamada, Kazuyuki Hirata, Haiyan Tao, Xioalin Li, Paul Crowe, Bruno Tse, Masayuki Kotoku, Akihiro Nomura, Ken Murase, Tsuyoshi Adachi, Ruo Steensma, Takayuki Yamaguchi, Makoto Shiozaki, Keishi Yamaguchi, Morgan Fenn, Scott Thacher, Satoki Doi, Shintaro Hirashima, Robert Babine
Publikováno v:
Genes to cells : devoted to molecularcellular mechanisms. 22(6)
Retinoid-related orphan receptor gamma (RORγ) directly controls the differentiation of Th17 cell and the production of interleukin-17, which plays an integral role in autoimmune diseases. To obtain insight into RORγ, we have determined the first cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5d2c9cb5064cdd4916b16d8cf238cb
https://pubmed.ncbi.nlm.nih.gov/28493531
https://pubmed.ncbi.nlm.nih.gov/28493531
Autor:
Naoki Miyagawa, Kota Asahina, Shintaro Hirashima, Scott Thacher, Satoki Doi, Masayuki Kotoku, Yukihiro Nomura, Katsuya Maeda, Shingo Obika, Haiyan Tao, Erin Bradley, Yoshiaki Katsuda, Paul Crowe, Seki Noriyoshi, Ruo Steensma, Takahiro Hata, Tsuyoshi Adachi, Robert Babine, Sakai Takayuki, Makoto Shiozaki, Kojo Arita, Masato Noguchi, Takaki Maeba, Xiaolin Li, Yasunori Hase, Morgan Fenn, Kazuyuki Hirata, Masafumi Kamada, Yusuke Aratsu, Akimi Hori, Takayuki Yamaguchi, Hiromasa Hashimoto
A novel series of RORγ inhibitors was identified starting with the HTS hit 1. After SAR investigation based on a prospective consideration of two drug-likeness metrics, ligand efficiency (LE) and fraction of sp(3) carbon atoms (Fsp(3)), significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a980bfa040ac0bdac6e9c6c9a5fd8c0
https://europepmc.org/articles/PMC4716592/
https://europepmc.org/articles/PMC4716592/
