Výsledky vyhledávání - "Morgan E. Hresko"

A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia

Autor: Qian Zhang, Morgan E. Hresko, Lora K. Picton, Leon Su, Michael J. Hollander, Selene Nunez-Cruz, Zheng Zhang, Charles-Antoine Assenmacher, Jonathan T. Sockolosky, K. Christopher Garcia, Michael C. Milone

Publikováno v: Sci Transl Med

Interleukin (IL)-2 is a central T cell cytokine that promotes T cell proliferation and effector function; however, toxicity due to its pluripotency limits its application to enhance CAR T cell immunotherapy. Previously, mouse IL-2 and its cognate rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399cd08790cb20fd80b9711eb9cc5bae
https://doi.org/10.1126/scitranslmed.abg6986

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