Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Morgan E. DeSantis"'
Autor:
Shuwen He, John P. Gillies, Juliana L. Zang, Carmen M. Córdoba-Beldad, Io Yamamoto, Yasuhiro Fujiwara, Julie Grantham, Morgan E. DeSantis, Hiroki Shibuya
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Male meiosis relies on canonical centrosomes for spindle formation, but how this differs from acentrosomal oocyte meiosis is unclear. Here they show that spindle formation in sperm relies on DYNLRB2, similar to the activity of DYNLRB1 in mitotic cell
Externí odkaz:
https://doaj.org/article/b077dccc14b24ed19264b85d32718b99
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Cytoplasmic dynein-1 (dynein) is the primary microtubule minus-end directed molecular motor in most eukaryotes. As such, dynein has a broad array of functions that range from driving retrograde-directed cargo trafficking to forming and focusing the m
Externí odkaz:
https://doaj.org/article/8eb4940d87ce4d409c2857df702e83de
Autor:
Ritvija Agrawal, John P Gillies, Juliana L Zang, Jingjing Zhang, Sharon R Garrott, Hiroki Shibuya, Jayakrishnan Nandakumar, Morgan E DeSantis
Publikováno v:
eLife, Vol 11 (2022)
Dynein harnesses ATP hydrolysis to move cargo on microtubules in multiple biological contexts. Dynein meets a unique challenge in meiosis by moving chromosomes tethered to the nuclear envelope to facilitate homolog pairing essential for gametogenesis
Externí odkaz:
https://doaj.org/article/8cd9e357cd00482caea76adfd06dae58
Autor:
Sharon R Garrott, John P Gillies, Aravintha Siva, Saffron R Little, Rita El Jbeily, Morgan E DeSantis
Publikováno v:
bioRxiv
Dynein is the primary minus-end-directed microtubule motor [1]. To achieve activation, dynein binds to the dynactin complex and an adaptor to form the “activated dynein complex” [2, 3]. The protein Lis1 aids activation by binding to dynein and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3c1e5b7f5c13ca85ec60f12728af47
https://europepmc.org/articles/PMC9900795/
https://europepmc.org/articles/PMC9900795/
Publikováno v:
eLife. 12
The lissencephaly 1 protein, LIS1, is mutated in type-1 lissencephaly and is a key regulator of cytoplasmic dynein-1. At a molecular level, current models propose that LIS1 activates dynein by relieving its autoinhibited form. Previously we reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2623d280e256fad193b1b6c5e890b6f
https://doi.org/10.7554/elife.84302
https://doi.org/10.7554/elife.84302
Autor:
Sharon R. Garrott, Morgan E. DeSantis
Publikováno v:
Trends in Biochemical Sciences. 48:315-316
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4913e5d5928dcfe192f1a9a5ead9e8a5
https://doi.org/10.1016/j.tibs.2023.01.007
https://doi.org/10.1016/j.tibs.2023.01.007
Autor:
William B Redwine, Morgan E DeSantis, Ian Hollyer, Zaw Min Htet, Phuoc Tien Tran, Selene K Swanson, Laurence Florens, Michael P Washburn, Samara L Reck-Peterson
Publikováno v:
eLife, Vol 6 (2017)
In human cells, cytoplasmic dynein-1 is essential for long-distance transport of many cargos, including organelles, RNAs, proteins, and viruses, towards microtubule minus ends. To understand how a single motor achieves cargo specificity, we identifie
Externí odkaz:
https://doaj.org/article/a142aea420de4a60919607041fbe4840
Autor:
Ritvija Agrawal, John P Gillies, Juliana L Zang, Jingjing Zhang, Sharon R Garrott, Hiroki Shibuya, Jayakrishnan Nandakumar, Morgan E DeSantis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3736edec25c04593676a8157d064ddaf
https://doi.org/10.7554/elife.78201.sa2
https://doi.org/10.7554/elife.78201.sa2
Autor:
Sharon R. Garrott, John P. Gillies, Aravintha Siva, Saffron R. Little, Rita El Jbeily, Morgan E. DeSantis
Publikováno v:
Journal of Biological Chemistry. :104735
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79321686abf8e81f1ce9544dbea2c016
https://doi.org/10.1016/j.jbc.2023.104735
https://doi.org/10.1016/j.jbc.2023.104735