Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Morgan E Lorkowski"'
Autor:
Gil Covarrubias, Yahan Zhang, Morgan E Lorkowski, Efstathios Karathanasis, Prabhani U. Atukorale, Taylor J. Moon, Wyatt M. Becicka, Peter Bielecki
Publikováno v:
Nanoscale Advances
The efficacy of immunotherapies is often limited by the immunosuppressive tumor microenvironment, which is populated with dysfunctional innate immune cells. To reprogram the tumor-resident innate immune cells, we developed immunostimulatory silica me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0067d39c4f683825a77fb0f0fcbe2173
http://europepmc.org/articles/PMC8386411
http://europepmc.org/articles/PMC8386411
Autor:
Prabhani U. Atukorale, Morgan E Lorkowski, Peter Bielecki, Efstathios Karathanasis, A.R. Santulli, Georgia Loutrianakis, Yahan Zhang, Kathleen Tong, Taylor Moon, Wyatt M. Becicka, Gil Covarrubias
Publikováno v:
J Control Release
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease, where even surgical resection and aggressive chemotherapy produce dismal outcomes. Immunotherapy is a promising alternative to conventional treatments, possessing the ability to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7e18e5df5f36357059434ad1989d82
https://doi.org/10.1016/j.jconrel.2020.11.014
https://doi.org/10.1016/j.jconrel.2020.11.014
Autor:
Gil Covarrubias, Taylor J. Moon, Shruthi Ravichandran, Efstathios Karathanasis, Prabhani U. Atukorale, Peter Bielecki, Michelle L. Wiese, Morgan E Lorkowski, Yahan Zhang, Wyatt M. Becicka
Publikováno v:
Nanoscale Horiz
The high mortality associated with glioblastoma multiforme (GBM) is attributed to its invasive nature, hypoxic core, resistant cell subpopulations and a highly immunosuppressive tumor microenvironment (TME). To support adaptive immune function and es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238583809ad92855af05a8e979d250e9
https://doi.org/10.1039/d0nh00446d
https://doi.org/10.1039/d0nh00446d
Autor:
Taylor J. Moon, Gil Covarrubias, Abdelrahman Rahmy, Anthony Cha, Anna Cristina S. Samia, Efstathios Karathanasis, Georgia Loutrianakis, Sameera Wickramasinghe, Morgan E Lorkowski, Haley M. Sims, Eric C. Abenojar
Publikováno v:
Nanoscale Advances
Iron oxide nanoparticles (IONPs) have often been investigated for tumor hyperthermia. IONPs act as heating foci in the presence of an alternating magnetic field (AMF). It has been shown that hyperthermia can significantly alter the tumor immune micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8360b63171d0d7dfd585e62aa0ebc157
https://doi.org/10.1039/d1na00116g
https://doi.org/10.1039/d1na00116g
Autor:
Mayura P Umapathy, Gil Covarrubias, Morgan E Lorkowski, Taylor J. Moon, Prabhani U. Atukorale, Georgia Loutrianakis, Haley M. Sims, Michelle L. Wiese, Efstathios Karathanasis, Peter Bielecki
Publikováno v:
J Mater Chem B
To alter the immunosuppressive tumor microenvironment (TME), we developed an immunostimulatory nanoparticle (NP) to reprogram a tumor’s dysfunctional and inhibitory antigen-presenting cells (APCs) into properly activated APCs that stimulate tumor-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0b7261985c46e73d2c9810600885e7
https://europepmc.org/articles/PMC8732314/
https://europepmc.org/articles/PMC8732314/
Autor:
Kathleen Tong, Taylor Moon, Pubudu M. Peiris, Aaron Yun, S. Raghunathan, Youngjun Park, Vindya S. Perera, Gil Covarrubias, Morgan E Lorkowski, Mark A. Griswold, Oguz Turan, Deobrat Dixit, Jeremy N. Rich, Georgia Loutrianakis, Efstathios Karathanasis, Shane Cooley, Peter Bielecki, Ketan B. Ghaghada
Publikováno v:
Adv Ther (Weinh)
Glioblastomas (GBMs) remain highly lethal. This partially stems from the presence of brain tumor initiating cells (BTICs), a highly plastic cellular subpopulation that is resistant to current therapies. In addition to resistance, the blood-brain barr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea20dc28fed7d9bd43bb123b2d063ead
https://pubmed.ncbi.nlm.nih.gov/32953978
https://pubmed.ncbi.nlm.nih.gov/32953978
Stimuli-Responsive Iron Oxide Nanotheranostics: A Versatile and Powerful Approach for Cancer Therapy
Publikováno v:
Adv Healthc Mater
Recent advancements in unravelling elements of cancer biology involved in disease progression and treatment resistance have highlighted the need for a holistic approach to effectively tackle cancer. Stimuli-responsive nanotheranostics based on iron o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a99a9d4041df2792edd87df90cc488f1
https://pubmed.ncbi.nlm.nih.gov/33225633
https://pubmed.ncbi.nlm.nih.gov/33225633
Autor:
Oguz Turan, Felicia He, B. Gnanasambandam, S. Raghunathan, C. Wu, Pubudu M. Peiris, Gil Covarrubias, Morgan E Lorkowski, William P Schiemann, Efstathios Karathanasis
Publikováno v:
Nanoscale. 10:6861-6871
Metastasis displays a highly heterogeneous cellular population with cancer cells continuously evolving. As a result, a single-ligand nanoparticle cannot account for the continuously changing expression of targetable biomarkers over time and space. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b471049e971487d01aae2ed46b394595
https://doi.org/10.1039/c8nr02513d
https://doi.org/10.1039/c8nr02513d
Autor:
Sonya E.L. Craig, Abdelrahman Rahmy, Debashish Roy, Efstathios Karathanasis, Mette L. Johansen, Anthony Cha, Morgan E Lorkowski, Bryan Scott, Madhusudhana Gargesha, Bernadette O. Erokwu, Christopher A Flask, Jason Vincent, Susann M. Brady-Kalnay, Christina J MacAskill, Gil Covarrubias
Publikováno v:
Nanomedicine
Poor prognosis for glioblastoma (GBM) is a consequence of the aggressive and infiltrative nature of gliomas where individual cells migrate away from the main tumor to distant sites, making complete surgical resection and treatment difficult. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3647d171a28971278bfa5994a213f1
https://pubmed.ncbi.nlm.nih.gov/32413511
https://pubmed.ncbi.nlm.nih.gov/32413511
Autor:
Gil Covarrubias, Ramamurthy Gopalakrishnan, S. Raghunathan, Pubudu M. Peiris, Abdelrahman Rahmy, Kathleen Tong, Mark A. Griswold, Morgan E Lorkowski, T Ouyang, A Yun, Efstathios Karathanasis, Vindya S. Perera, Peter Bielecki, Ketan B. Ghaghada, Oguz Turan
Publikováno v:
Nanoscale
Glioblastomas are highly lethal cancers defined by resistance to conventional therapies and rapid recurrence. While new brain tumor cell-specific drugs are continuously becoming available, efficient drug delivery to brain tumors remains a limiting fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a37b73b948b75fa950e969742ddf55f
https://europepmc.org/articles/PMC7776621/
https://europepmc.org/articles/PMC7776621/