Výsledky vyhledávání - "Morgan D. Salmon"

Akademický článek

Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation

Autor: Amanda C. Filiberto, Michael D. Spinosa, Craig T. Elder, Gang Su, Victoria Leroy, Zachary Ladd, Guanyi Lu, J. Hunter Mehaffey, Morgan D. Salmon, Robert B. Hawkins, Kodi S. Ravichandran, Brant E. Isakson, Gilbert R. Upchurch, Ashish K. Sharma

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)

Pannexin-1 ion channels on endothelial cells regulate vascular inflammation and remodeling to mediate aortic aneurysm formation. Pharmacological blockade of Pannexin-1 channels may offer translational therapeutic mitigation of aneurysmal pathology.

Externí odkaz: https://doaj.org/article/5d2bdb9d8cc044ab83c636b0eec19b6c

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Abstract 11550: Human Mesenchymal Stem Cell-Derived Microvesicles Mitigate Aortic Smooth Muscle Cell Activation via miR-147 and Attenuate Aortic Aneurysm Formation

Autor: Ashish K Sharma, Guanyi Lu, Morgan D Salmon, Ricardo C Gehrau, Valeria R Mas, Mark L Weiss, Gorav Ailawadi, Gilbert R Upchurch

Publikováno v: Circulation. 132

Objective: Mesenchymal stem cells (MSCs) can release microvesicles (MVs) but their effects on aortic aneurysm (AA) formation are unknown. We hypothesize that MSC-derived MVs can inhibit AA formation via modulation of specific microRNAs (miRs). Method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bfca20ef932ab1985d702c4c5b08bf7
https://doi.org/10.1161/circ.132.suppl_3.11550

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