Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Morgan D Fullerton"'
Autor:
Peyman Ghorbani, Sang Yong Kim, Tyler K T Smith, Lucía Minarrieta, Victoria Robert-Gostlin, Marisa K Kilgour, Maja Ilijevska, Irina Alecu, Shayne A Snider, Kaitlyn D Margison, Julia R C Nunes, Daniel Woo, Ciara Pember, Conor O'Dwyer, Julie Ouellette, Pavel Kotchetkov, Julie St-Pierre, Steffany A L Bennett, Baptiste Lacoste, Alexandre Blais, Meera G Nair, Morgan D Fullerton
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011658 (2023)
Type 2 cytokines like IL-4 are hallmarks of helminth infection and activate macrophages to limit immunopathology and mediate helminth clearance. In addition to cytokines, nutrients and metabolites critically influence macrophage polarization. Choline
Externí odkaz:
https://doaj.org/article/90d98c83331e4ab19bdf970a30da6155
Autor:
Corina M Stewart, Alexandra Phan, Yuxia Bo, Nicholas D LeBlond, Tyler K T Smith, Geneviève Laroche, Patrick M Giguère, Morgan D Fullerton, Martin Pelchat, Darwyn Kobasa, Marceline Côté
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009275 (2021)
Filoviruses, such as the Ebola virus (EBOV) and Marburg virus (MARV), are causative agents of sporadic outbreaks of hemorrhagic fevers in humans. To infect cells, filoviruses are internalized via macropinocytosis and traffic through the endosomal pat
Externí odkaz:
https://doaj.org/article/c6998978276948f2b5a5a62d2e027cdc
Autor:
Emmanuel Denou, Karine Lolmède, Lucile Garidou, Celine Pomie, Chantal Chabo, Trevor C Lau, Morgan D Fullerton, Giulia Nigro, Alexia Zakaroff‐Girard, Elodie Luche, Céline Garret, Matteo Serino, Jacques Amar, Michael Courtney, Joseph F Cavallari, Brandyn D Henriksbo, Nicole G Barra, Kevin P Foley, Joseph B McPhee, Brittany M Duggan, Hayley M O'Neill, Amanda J Lee, Philippe Sansonetti, Ali A Ashkar, Waliul I Khan, Michael G Surette, Anne Bouloumié, Gregory R Steinberg, Rémy Burcelin, Jonathan D Schertzer
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 3, Pp 259-274 (2015)
Abstract Pattern recognition receptors link metabolite and bacteria‐derived inflammation to insulin resistance during obesity. We demonstrate that NOD2 detection of bacterial cell wall peptidoglycan (PGN) regulates metabolic inflammation and insuli
Externí odkaz:
https://doaj.org/article/1803a973f117402abe470b9a81cd7cf9
Autor:
Meaghen Rollins, Sylvain Huard, Alan Morettin, Jennifer Takuski, Trang Thuy Pham, Morgan D Fullerton, Jocelyn Côté, Kristin Baetz
Publikováno v:
PLoS Genetics, Vol 13, Iss 2, p e1006626 (2017)
Eukaryotic cells form stress granules under a variety of stresses, however the signaling pathways regulating their formation remain largely unknown. We have determined that the Saccharomyces cerevisiae lysine acetyltransferase complex NuA4 is require
Externí odkaz:
https://doaj.org/article/96a1eee42e0d4eae868d2f2d0c859d79
Autor:
Man K.S. Lee, Olivia D. Cooney, Xuzhu Lin, Shaktypreya Nadarajah, Dragana Dragoljevic, Kevin Huynh, Danise-Ann Onda, Sandra Galic, Peter J. Meikle, Thomas Edlund, Morgan D. Fullerton, Bruce E. Kemp, Andrew J. Murphy, Kim Loh
Publikováno v:
Molecular Metabolism, Vol 61, Iss , Pp 101514- (2022)
Objectives: Dysregulation of cholesterol metabolism in the liver and hematopoietic stem and progenitor cells (HSPCs) promotes atherosclerosis development. Previously, it has been shown that HMG-CoA-Reductase (HMGCR), the rate-limiting enzyme in the m
Externí odkaz:
https://doaj.org/article/8e3ca735c9ca4ee3934879d9b15a6a5b
Autor:
Julia R.C. Nunes, Tyler K.T. Smith, Peyman Ghorbani, Conor O'Dwyer, Natasha A. Trzaskalski, Habiba Dergham, Ciara Pember, Marisa K. Kilgour, Erin E. Mulvihill, Morgan D. Fullerton
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism.
Metabolic dysfunction-associated fatty liver disease (MAFLD) represents a growing cause of mortality and morbidity and encompasses a spectrum of liver pathologies. While dozens of preclinical models have been developed to recapitulate stages of MAFLD
Autor:
Julia R.C. Nunes, Tyler K.T. Smith, Peyman Ghorbani, Conor O’Dwyer, Natasha A. Trzaskalski, Habiba Dergham, Ciara Pember, Marisa K. Kilgour, Erin E. Mulvihill, Morgan D. Fullerton
ObjectiveMetabolic dysfunction-associated fatty liver disease (MAFLD) represents a growing cause of mortality and morbidity and encompasses a spectrum of liver pathologies. Potential therapeutic targets have been identified and are currently being pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97799496696775ed8d54eaf274a706c2
https://doi.org/10.1101/2023.01.24.524609
https://doi.org/10.1101/2023.01.24.524609
Autor:
Natasha A. Trzaskalski, Branka Vulesevic, My-Anh Nguyen, Natasha Jeraj, Evgenia Fadzeyeva, Nadya M. Morrow, Cassandra A.A. Locatelli, Nicole Travis, Antonio A. Hanson, Julia R.C. Nunes, Conor O’Dwyer, Jelske N. van der Veen, Ilka Lorenzen-Schmidt, Rick Seymour, Serena M. Pulente, Andrew C. Clément, Angela M. Crawley, René L. Jacobs, Mary-Anne Doyle, Curtis L. Cooper, Kyoung-Han Kim, Morgan D. Fullerton, Erin E. Mulvihill
Publikováno v:
JCI Insight. 8
Autor:
Natasha A, Trzaskalski, Branka, Vulesevic, My-Anh, Nguyen, Natasha, Jeraj, Evgenia, Fadzeyeva, Nadya M, Morrow, Cassandra Aa, Locatelli, Nicole, Travis, Antonio A, Hanson, Julia Rc, Nunes, Conor, O'Dwyer, Jelske N, Van der Veen, Ilka, Lorenzen-Schmidt, Rick, Seymour, Serena M, Pulente, Andrew C, Clément, Angela M, Crawley, René L, Jacobs, Mary-Anne, Doyle, Curtis L, Cooper, Kyoung-Han, Kim, Morgan D, Fullerton, Erin E, Mulvihill
Publikováno v:
JCI insight.
Elevated circulating dipeptidyl-peptidase 4 is a biomarker for liver disease, but its involvement in gluconeogenesis and in metabolic-associated fatty liver disease (MAFLD) progression remains unclear. Here we identified that DPP4 in hepatocytes but
Autor:
Peyman Ghorbani, Sang Yong Kim, Tyler K.T. Smith, Lucía Minarrieta, Marisa K. Kilgour, Maja Ilijevska, Irina Alecu, Shayne A. Snider, Kaitlyn D. Margison, Julia R.C. Nunes, Daniel Woo, Ciara Pember, Conor O’Dwyer, Julie St-Pierre, Steffany A.L. Bennett, Meera G. Nair, Morgan D. Fullerton
Choline is an essential nutrient and in macrophages, mainly supports phosphatidylcholine (PC) synthesis. Cellular uptake and incorporation of choline into PC is critical for LPS-induced macrophage inflammation. Here, we examined choline metabolism in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0764d0bfb3645b653937339ae6a24fd
https://doi.org/10.1101/2022.09.30.510305
https://doi.org/10.1101/2022.09.30.510305