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pro vyhledávání: '"Morgan Crewe"'
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113809- (2024)
Summary: We trapped catalytically engaged topoisomerase IIβ (TOP2B) in covalent DNA cleavage complexes (TOP2Bccs) and mapped their positions genome-wide in cultured mouse cortical neurons. We report that TOP2Bcc distribution varies with both nucleos
Externí odkaz:
https://doaj.org/article/94331674ade94e929595ea7c831a18a7
Autor:
Morgan Crewe, Ram Madabhushi
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
The nervous system is vulnerable to genomic instability and mutations in DNA damage response factors lead to numerous developmental and progressive neurological disorders. Despite this, the sources and mechanisms of DNA damage that are most relevant
Externí odkaz:
https://doaj.org/article/28d051b1724940e0bb7fe3239781cf3d