Výsledky vyhledávání - "Morgan C Nelson"

Akademický článek

Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease.

Autor: Marah C Runtsch, Morgan C Nelson, Soh-Hyun Lee, Warren Voth, Margaret Alexander, Ruozhen Hu, Jared Wallace, Charisse Petersen, Vanja Panic, Claudio J Villanueva, Kimberley J Evason, Kaylyn M Bauer, Timothy Mosbruger, Sihem Boudina, Mary Bronner, June L Round, Micah J Drummond, Ryan M O'Connell

Publikováno v: PLoS Genetics, Vol 15, Iss 2, p e1007970 (2019)

Identifying regulatory mechanisms that influence inflammation in metabolic tissues is critical for developing novel metabolic disease treatments. Here, we investigated the role of microRNA-146a (miR-146a) during diet-induced obesity in mice. miR-146a

Externí odkaz: https://doaj.org/article/0b801b0c45b84c1488fd88a3d64a9028

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Evaporative Cooler Use Influences Temporal Indoor Relative Humidity but Not Dust Mite Allergen Levels in Homes in a Semi-Arid Climate.

Autor: James D Johnston, Steven C Tuttle, Morgan C Nelson, Rebecca K Bradshaw, Taylor G Hoybjerg, Julene B Johnson, Bryce A Kruman, Taylor S Orton, Ryan B Cook, Dennis L Eggett, K Scott Weber

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0147105 (2016)

Concerns about energy consumption and climate change make residential evaporative coolers a popular alternative to central air conditioning in arid and semi-arid climates. However, evaporative coolers have been shown to significantly increase indoor

Externí odkaz: https://doaj.org/article/166aae052e95424eb4dd5f48917923eb

Zobrazit plný text záznamu

Akademický článek

miRNA-1 promotes acute myeloid leukemia cell pathogenesis through metabolic regulation

Autor: Arevik Ghazaryan, Jared A. Wallace, William W. Tang, Cindy Barba, Soh-Hyun Lee, Kaylyn M. Bauer, Morgan C. Nelson, Carissa N. Kim, Chris Stubben, Warren P. Voth, Dinesh S. Rao, Ryan M. O’Connell

Publikováno v: Frontiers in Genetics, Vol 14 (2023)

Acute myeloid leukemia (AML) is a heterogeneous and deadly disease characterized by uncontrolled expansion of malignant blasts. Altered metabolism and dysregulated microRNA (miRNA) expression profiles are both characteristic of AML. However, there is

Externí odkaz: https://doaj.org/article/7398a18c853e402d9edaebb274d37ba5

Zobrazit plný text záznamu

Akademický článek

CD11c+ myeloid cell exosomes reduce intestinal inflammation during colitis

Publikováno v: JCI Insight, Vol 7, Iss 19 (2022)

Intercellular communication is critical for homeostasis in mammalian systems, including the gastrointestinal (GI) tract. Exosomes are nanoscale lipid extracellular vesicles that mediate communication between many cell types. Notably, the roles of imm

Externí odkaz: https://doaj.org/article/28e27534285f41e8b7743abd9a89a3a7

Zobrazit plný text záznamu

Clec12a tempers inflammation while restricting expansion of a colitogenic commensal

Autor: Tyson R. Chiaro, Kaylyn M. Bauer, Kyla S. Ost, Emmanuel Stephen-Victor, Morgan C. Nelson, Jennifer H. Hill, Rickesha Bell, Morgan Harwood, Warren Voth, Taylor Jackson, Kendra A Klag, Ryan M. O’Connell, W. Zac Stephens, June L. Round

Publikováno v: bioRxiv

SUMMARYRegulation of the microbiota is critical to intestinal health yet the mechanisms employed by innate immunity remain unclear. Here we show that mice deficient in the C-Type-lectin receptor, Clec12a developed severe colitis, which was dependent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1f6f83e6b69bc3240b7d317804f7ff
https://europepmc.org/articles/PMC10055051/

Zobrazit plný text záznamu

T Cell–Expressed microRNA-155 Reduces Lifespan in a Mouse Model of Age-Related Chronic Inflammation

Autor: Jared Wallace, Ryan M. O'Connell, H. Atakan Ekiz, Dinesh S. Rao, Soh-Hyun Lee, Micah J. Drummond, Morgan C. Nelson, June L. Round, Ruozhen Hu, Andrew G. Ramstead, Kaylyn M. Bauer, Jared Rutter

Publikováno v: J Immunol

Aging-related chronic inflammation is a risk factor for many human disorders through incompletely understood mechanisms. Aged mice deficient in microRNA (miRNA/miR)-146a succumb to life-shortening chronic inflammation. In this study, we report that m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df68690f80804187c37fda9d4cb2410
https://doi.org/10.4049/jimmunol.1901484

Zobrazit plný text záznamu

MicroRNAs: At the Interface of Metabolic Pathways and Inflammatory Responses by Macrophages

Autor: Ryan M. O'Connell, Morgan C. Nelson

Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology

Macrophages are key cells of the innate immune system with functional roles in both homeostatic maintenance of self-tissues and inflammatory responses to external stimuli, including infectious agents. Recent advances in metabolic research have reveal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67114e5f549441f6649ef7d16d3fba8

Zobrazit plný text záznamu

A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages

Autor: Marah C. Runtsch, Soh-Hyun Lee, H. Atakan Ekiz, Ryan M. O'Connell, Thomas B. Huffaker, Timothy L. Mosbruger, Kaylyn M. Bauer, Warren P. Voth, Morgan C. Nelson, June L. Round, Cindy Barba, William W. Tang, James E. Cox

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

Tumor associated macrophage responses are regulated by distinct metabolic states that affect their function. However, the ability of specific signals in the local tumor microenvironment to program macrophage metabolism remains under investigation. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cefb49672322d5c2aa94107b0824f78c
https://pubmed.ncbi.nlm.nih.gov/33976173

Zobrazit plný text záznamu