Mitophagy protects β cells from inflammatory damage in diabetes

Autor: Vaibhav Sidarala, Gemma L. Pearson, Vishal S. Parekh, Benjamin Thompson, Lisa Christen, Morgan A. Gingerich, Jie Zhu, Tracy Stromer, Jianhua Ren, Emma C. Reck, Biaoxin Chai, John A. Corbett, Thomas Mandrup-Poulsen, Leslie S. Satin, Scott A. Soleimanpour

Publikováno v: JCI Insight, Vol 5, Iss 24 (2020)

Inflammatory damage contributes to β cell failure in type 1 and 2 diabetes (T1D and T2D, respectively). Mitochondria are damaged by inflammatory signaling in β cells, resulting in impaired bioenergetics and initiation of proapoptotic machinery. Hen

Externí odkaz: https://doaj.org/article/5621b7dc174d44beb66d61a7da10a016

A Selective Look at Autophagy in Pancreatic β-Cells

Autor: Trevor J. Biden, Gemma L. Pearson, Scott A. Soleimanpour, Morgan A. Gingerich, Emily M. Walker

Publikováno v: Diabetes

Insulin-producing pancreatic β-cells are central to glucose homeostasis, and their failure is a principal driver of diabetes development. To preserve optimal health β-cells must withstand both intrinsic and extrinsic stressors, ranging from inflamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2909e518f4c7b38d64b3e6539675a0
https://doi.org/10.2337/dbi20-0014

An intrinsically disordered protein region encoded by the human disease gene

Autor: Morgan A, Gingerich, Xueying, Liu, Biaoxin, Chai, Gemma L, Pearson, Michael P, Vincent, Tracy, Stromer, Jie, Zhu, Vaibhav, Sidarala, Aaron, Renberg, Debashish, Sahu, Daniel J, Klionsky, Santiago, Schnell, Scott A, Soleimanpour

Publikováno v: Autophagy

CLEC16A regulates mitochondrial health through mitophagy and is associated with over 20 human diseases. However, the key structural and functional regions of CLEC16A, and their relevance for human disease, remain unknown. Here, we report that a disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ccd59a485e9fe61f03973cfe036db1f
https://pubmed.ncbi.nlm.nih.gov/35604110

The human disease gene CLEC16A encodes an intrinsically disordered protein region required for mitochondrial quality control

Autor: Jie Zhu, Xueying Liu, Gemma L. Pearson, Aaron Renberg, Scott A. Soleimanpour, Vaibhav Sidarala, Debashish Sahu, Morgan A. Gingerich, Daniel J. Klionsky, Biaoxin Chai, Michael S. Vincent, Santiago Schnell, Tracy Stromer

CLEC16A regulates mitochondrial health through mitophagy and is associated with over 20 human diseases. While CLEC16A has ubiquitin ligase activity, the key structural and functional regions of CLEC16A, and their relevance for human disease, remain u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fca2367b58f28836f0dcde599da7b302
https://doi.org/10.1101/2021.09.03.458272

Mitophagy protects beta cells from inflammatory damage in diabetes

Autor: John A. Corbett, Emma C. Reck, Scott A. Soleimanpour, Biaoxin Chai, Morgan A. Gingerich, Benjamin Thompson, Lisa Christen, Thomas Mandrup-Poulsen, Vishal S. Parekh, Gemma L. Pearson, Vaibhav Sidarala, Leslie S. Satin, Jianhua Ren, Jie Zhu, Tracy Stromer

Publikováno v: JCI Insight
JCI Insight, Vol 5, Iss 24 (2020)
Sidarala, V, Pearson, G L, Parekh, V S, Thompson, B, Christen, L, Gingerich, M A, Zhu, J, Stromer, T, Ren, J, Reck, E C, Chai, B, Corbett, J A, Mandrup-Poulsen, T, Satin, L S & Soleimanpour, S A 2020, ' Mitophagy protects beta cells from inflammatory damage in diabetes ', JCI insight, vol. 5, no. 24, 141138 . https://doi.org/10.1172/jci.insight.141138

Inflammatory damage contributes to β-cell failure in type 1 and 2 diabetes (T1D and T2D). Mitochondria are damaged by inflammatory signaling in β-cells, resulting in impaired bioenergetics and initiation of pro-apoptotic machinery. Hence, the ident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95489b3a754e5976312f493596ac093
https://doi.org/10.1101/2020.06.07.138917