Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Morgan A. Coburn"'
Autor:
Akhabue K. Okojie, Joseph O. Uweru, Morgan A. Coburn, Sihan Li, Vivian D. Cao-Dao, Ukpong B. Eyo
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-17 (2023)
Abstract Microglia, the primary immune cells of the central nervous system (CNS), are derived from the yolk sac and populate the brain during development. Once microglia migrate to the CNS, they are self-renewing and require CSF1R signaling for their
Externí odkaz:
https://doaj.org/article/6135ff905552462dab4b03bafd35cb55
Autor:
Hayk Davtyan, Armine Hovakimyan, Sepideh Kiani Shabestari, Tatevik Antonyan, Morgan A. Coburn, Karen Zagorski, Gor Chailyan, Irina Petrushina, Olga Svystun, Emma Danhash, Nikolai Petrovsky, David H. Cribbs, Michael G. Agadjanyan, Mathew Blurton-Jones, Anahit Ghochikyan
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-13 (2019)
Abstract Background Alzheimer disease (AD) is characterized by the accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau, which together lead to neurodegeneration and cognitive decline. Current the
Externí odkaz:
https://doaj.org/article/5972ea523f564c8fabf6e4f05a708840
Autor:
Sepideh Kiani Shabestari, Samuel Morabito, Emma Pascal Danhash, Amanda McQuade, Jessica Ramirez Sanchez, Emily Miyoshi, Jean Paul Chadarevian, Christel Claes, Morgan Alexandra Coburn, Jonathan Hasselmann, Jorge Hidalgo, Kayla Nhi Tran, Alessandra C. Martini, Winston Chang Rothermich, Jesse Pascual, Elizabeth Head, David A. Hume, Clare Pridans, Hayk Davtyan, Vivek Swarup, Mathew Blurton-Jones
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110961- (2022)
Summary: Microglia are strongly implicated in the development and progression of Alzheimer’s disease (AD), yet their impact on pathology and lifespan remains unclear. Here we utilize a CSF1R hypomorphic mouse to generate a model of AD that genetica
Externí odkaz:
https://doaj.org/article/def9c689b7ba47e59182ba5cb0a6929b
Publikováno v:
Immunological Reviews. 311:26-38
The diploë region of skull has recently been discovered to act as a myeloid cell reservoir to the underlying meninges. The presence of ossified vascular channels traversing the inner skull of cortex provides a passageway for the cells to traffic fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0b56360eb1c6a5281cb922d8d6e05e
https://doi.org/10.1111/imr.13120
https://doi.org/10.1111/imr.13120
Autor:
Christel Claes, Whitney E. England, Emma P. Danhash, Sepideh Kiani Shabestari, Amit Jairaman, Jean Paul Chadarevian, Jonathan Hasselmann, Andy P. Tsai, Morgan A. Coburn, Jessica Sanchez, Tau En Lim, Jorge L. S. Hidalgo, Christina Tu, Michael D. Cahalan, Bruce T. Lamb, Gary E. Landreth, Robert C. Spitale, Mathew Blurton‐Jones, Hayk Davtyan
Publikováno v:
Alzheimer's & Dementia. 18:1765-1778
The P522R variant of PLCG2, expressed by microglia, is associated with reduced risk of Alzheimer's disease (AD). Yet, the impact of this protective mutation on microglial responses to AD pathology remains unknown. Chimeric AD and wild-type mice were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463825c6c305b25a2f0c80da82f03755
https://doi.org/10.1002/alz.12577
https://doi.org/10.1002/alz.12577
Autor:
Sepideh Kiani Shabestari, Samuel Morabito, Emma Pascal Danhash, Amanda McQuade, Jessica Ramirez Sanchez, Emily Miyoshi, Jean Paul Chadarevian, Christel Claes, Morgan Alexandra Coburn, Jonathan Hasselmann, Jorge Hidalgo, Kayla Nhi Tran, Alessandra C. Martini, Winston Chang Rothermich, Jesse Pascual, Elizabeth Head, David A. Hume, Clare Pridans, Hayk Davtyan, Vivek Swarup, Mathew Blurton-Jones
Publikováno v:
Cell reports, vol 39, iss 11
Kiani Shabestari, S, Morabito, S, Danhash, E P, Mcquade, A, Sanchez, J R, Miyoshi, E, Chadarevian, J P, Claes, C, Coburn, M A, Hasselmann, J, Hidalgo, J, Tran, K N, Martini, A C, Chang Rothermich, W, Pascual, J, Head, E, Hume, D A, Pridans, C, Davtyan, H, Swarup, V & Blurton-jones, M 2022, ' Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice ', Cell Reports, vol. 39, no. 11, pp. 110961 . https://doi.org/10.1016/j.celrep.2022.110961
Kiani Shabestari, S, Morabito, S, Danhash, E P, Mcquade, A, Sanchez, J R, Miyoshi, E, Chadarevian, J P, Claes, C, Coburn, M A, Hasselmann, J, Hidalgo, J, Tran, K N, Martini, A C, Chang Rothermich, W, Pascual, J, Head, E, Hume, D A, Pridans, C, Davtyan, H, Swarup, V & Blurton-jones, M 2022, ' Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice ', Cell Reports, vol. 39, no. 11, pp. 110961 . https://doi.org/10.1016/j.celrep.2022.110961
Microglia are strongly implicated in the development and progression of Alzheimer’s disease (AD), yet their impact on pathology and lifespan remains unclear. Here we utilize a CSF1R hypomorphic mouse to generate a model of AD that genetically lacks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c78dcff618ff5018b6cf688da02cd7ef
https://pubmed.ncbi.nlm.nih.gov/35705056
https://pubmed.ncbi.nlm.nih.gov/35705056
Autor:
Morgan A. Coburn, Amanda McQuade, Christina H. Tu, Jonathan Hasselmann, Hayk Davtyan, Mathew Blurton-Jones
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-13 (2018)
Molecular Neurodegeneration
McQuade, Amanda; Coburn, Morgan; Tu, Christina H; Hasselmann, Jonathan; Davtyan, Hayk; & Blurton-Jones, Mathew. (2018). Development and validation of a simplified method to generate human microglia from pluripotent stem cells.. Molecular neurodegeneration, 13(1), 67. doi: 10.1186/s13024-018-0297-x. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6978s3qz
Molecular Neurodegeneration
McQuade, Amanda; Coburn, Morgan; Tu, Christina H; Hasselmann, Jonathan; Davtyan, Hayk; & Blurton-Jones, Mathew. (2018). Development and validation of a simplified method to generate human microglia from pluripotent stem cells.. Molecular neurodegeneration, 13(1), 67. doi: 10.1186/s13024-018-0297-x. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6978s3qz
Background Microglia, the principle immune cells of the brain, play important roles in neuronal development, homeostatic function and neurodegenerative disease. Recent genetic studies have further highlighted the importance of microglia in neurodegen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00dc6f44aae49bf37bf9c81afb3fbc80
http://link.springer.com/article/10.1186/s13024-018-0297-x
http://link.springer.com/article/10.1186/s13024-018-0297-x
Autor:
Christel Claes, Jonathan Hasselmann, Emma Danhash, Jorge Silva, Hayk Davtyan, Tau En Lim, Morgan A. Coburn, Sepideh Kiani Shabestari, Amit Jairaman, Jean Paul Chadarevian, Christina H. Tu, Mathew Blurton-Jones, Michael D. Cahalan
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1af97fa74569c6305ebf8b70effc872
https://doi.org/10.1002/alz.041539
https://doi.org/10.1002/alz.041539
Autor:
Tatevik Antonyan, Michael G. Agadjanyan, Olga Svystun, Karen Zagorski, Hayk Davtyan, David H. Cribbs, Gor Chailyan, Sepideh Kiani Shabestari, Irina Petrushina, Nikolai Petrovsky, Armine Hovakimyan, Mathew Blurton-Jones, Morgan A. Coburn, Anahit Ghochikyan, Emma Danhash
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-13 (2019)
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy
Background Alzheimer disease (AD) is characterized by the accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau, which together lead to neurodegeneration and cognitive decline. Current therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28c9b2d1d622411cd3f3a9a9f02ab13
https://doi.org/10.1186/s13195-019-0556-2
https://doi.org/10.1186/s13195-019-0556-2
Autor:
Morgan A. Coburn, Judith T. Zelikoff, Jared J. Schwartzer, Jason L. Blum, Pamella B. Tijerina, Jamie S. Church, Felicity J. Emerson
Publikováno v:
NeuroToxicology. 65:231-240
Exposure to fine ambient particulates (PM(2.5)) during gestation or neonatally has potent neurotoxic effects. While biological and behavioral data indicate a vulnerability to environmental pollutants across distinct neurodevelopmental windows, the be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c155a057ec641d42a70219731a16e47
https://doi.org/10.1016/j.neuro.2017.10.007
https://doi.org/10.1016/j.neuro.2017.10.007