[Letter to the Editor] Assessment of mononuclear cell populations derived from human umbilical cord blood

Autor: Olaitan, S, Wagstaff, M, Sevim, O, Akieme, R, Toska, V, Humphreys, C, Shah‐Goodwin, L, Bell, J, Chevassut, T, Morgan, R G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::0fe2fed1919c19944d9147958279ac58
http://sro.sussex.ac.uk/id/eprint/107541/1/17501021.pdf

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Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: implications for targeting cancer stem cells.

Autor: Morgan, R G¹, Molnár, E², Jones, R F¹, Collard, T J¹, Lane, J D³, Greenhough, A¹, Paraskeva, C¹, Williams, A C¹

Publikováno v: British Journal of Cancer. 2/17/2015, Vol. 112 Issue 4, p714-719. 6p. 3 Graphs.

LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity

Autor: Morgan, R G, Mortensson, E, Legge, D N, Gupta, B, Collard, T J, Greenhough, A, Williams, A C

Publikováno v: Morgan, R G, Mortensson, E, Legge, D N, Gupta, B, Collard, T J, Greenhough, A & Williams, A C 2018, ' LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity ', British Journal of Cancer, vol. 118, no. 4, pp. 558-565 . https://doi.org/10.1038/bjc.2017.412
British Journal of Cancer

BACKGROUND: LGR5 serves as a co-receptor for Wnt/β-catenin signalling and marks normal intestinal stem cells; however, its role in colorectal cancer (CRC) remains controversial. LGR5(+) cells are known to exist outside the stem cell niche during CRC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8d1777b1c1ee9d2daa80034a055315bb
https://research-information.bris.ac.uk/en/publications/5da99d41-043c-4f19-b249-26ab9ddeef49

γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin.

Autor: Morgan, R G¹, Pearn, L¹, Liddiard, K¹, Pumford, S L¹, Burnett, A K¹, Tonks, A¹, Darley, R L¹

Publikováno v: Leukemia (08876924). Feb2013, Vol. 27 Issue 2, p336-343. 8p. 1 Diagram, 5 Graphs.