Targeting protein homeostasis with small molecules as a strategy for the development of pan-coronavirus antiviral therapies.

Autor: Mao YQ; Department of Biochemistry, University of Toronto, Toronto, ON, Canada., Jahanshahi S; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Malty R; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.; Department of Chemistry and Biochemistry, University of Regina, Regina, SK, Canada., Van Ommen DAJ; Department of Biochemistry, University of Toronto, Toronto, ON, Canada., Wan Y; Department of Biochemistry, University of Toronto, Toronto, ON, Canada., Morey TM; Department of Biochemistry, University of Toronto, Toronto, ON, Canada., Chuang SHW; Department of Biochemistry, University of Toronto, Toronto, ON, Canada., Pavlova V; Department of Biochemistry, University of Toronto, Toronto, ON, Canada., Ahmed C; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Dahal S; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Lin F; Department of Chemistry, University of Toronto, Toronto, ON, Canada., Mangos M; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Nurtanto J; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Song Y; Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada., Been T; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Christie-Holmes N; Toronto High Containment Facility, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Gray-Owen SD; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Toronto High Containment Facility, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Babu M; Department of Chemistry and Biochemistry, University of Regina, Regina, SK, Canada., Wong AP; Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada., Batey RA; Department of Chemistry, University of Toronto, Toronto, ON, Canada., Attisano L; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Cochrane A; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Houry WA; Department of Biochemistry, University of Toronto, Toronto, ON, Canada. walid.houry@utoronto.ca.; Department of Chemistry, University of Toronto, Toronto, ON, Canada. walid.houry@utoronto.ca.

Publikováno v: Communications biology [Commun Biol] 2024 Nov 07; Vol. 7 (1), pp. 1460. Date of Electronic Publication: 2024 Nov 07.

SPAAC Pulse-Chase: A Novel Click Chemistry-Based Method to Determine the Half-Life of Cellular Proteins.

Autor: Morey TM; Molecular Medicine Research Group, Robarts Research Institute, Western University, London, ON, Canada.; Department of Physiology and Pharmacology, Western University, London, ON, Canada., Esmaeili MA; Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada., Duennwald ML; Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada., Rylett RJ; Molecular Medicine Research Group, Robarts Research Institute, Western University, London, ON, Canada.; Department of Physiology and Pharmacology, Western University, London, ON, Canada.

Publikováno v: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2021 Sep 07; Vol. 9, pp. 722560. Date of Electronic Publication: 2021 Sep 07 (Print Publication: 2021).

Enhanced ubiquitination and proteasomal degradation of catalytically deficient human choline acetyltransferase mutants.

Autor: Morey TM; Molecular Medicine Research Group, Robarts Research Institute, Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada., Albers S; Molecular Medicine Research Group, Robarts Research Institute, Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada., Shilton BH; Department of Biochemistry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada., Rylett RJ; Molecular Medicine Research Group, Robarts Research Institute, Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada.

Publikováno v: Journal of neurochemistry [J Neurochem] 2016 May; Vol. 137 (4), pp. 630-46. Date of Electronic Publication: 2016 Mar 15.

Heat shock inhibition of CDK5 increases NOXA levels through miR-23a repression.

Autor: Morey TM; From the Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada., Roufayel R; From the Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada., Johnston DS; From the Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada., Fletcher AS; From the Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada., Mosser DD; From the Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada rmosser@uoguelph.ca.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2015 May 01; Vol. 290 (18), pp. 11443-54. Date of Electronic Publication: 2015 Mar 31.