Single-cell immune profiling reveals thymus-seeding populations, T cell commitment, and multilineage development in the human thymus

Autor: Cordes, M., Cante-Barrett, K., Akker, E.B. van den, Moretti, F.A., Kielbasa, S.M., Vloemans, S.A., Garcia-Perez, L., Teodosio, C., Dongen, J.J.M. van, Pike-Overzet, K., Reinders, M.J.T., Staal, F.J.T.

Publikováno v: Science Immunology, 7(77). AMER ASSOC ADVANCEMENT SCIENCE

T cell development in the mouse thymus has been studied extensively, but less is known regarding T cell development in the human thymus. We used a combination of single-cell techniques and functional assays to perform deep immune profiling of human T

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https://hdl.handle.net/1887/3570605

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MDM2-Regulated Degradation of HIPK2 Prevents p53Ser46 Phosphorylation and DNA Damage-Induced Apoptosis

Autor: Rinaldo C.1, Prodosmo A, 1, Mancini F.1, 2, Iacovelli S.1, Sacchi A.1, Moretti F.1, Soddu S.1

Publikováno v: Molecular cell 25 (2007): 739–750. doi:10.1016/j.molcel.2007.02.008
info:cnr-pdr/source/autori:Rinaldo C.1, Prodosmo A,1, Mancini F.1,2, Iacovelli S.1, Sacchi A.1, Moretti F.1,2, Soddu S.1/titolo:MDM2-Regulated Degradation of HIPK2 Prevents p53Ser46 Phosphorylation and DNA Damage-Induced Apoptosis./doi:10.1016%2Fj.molcel.2007.02.008/rivista:Molecular cell/anno:2007/pagina_da:739/pagina_a:750/intervallo_pagine:739–750/volume:25

In response to DNA damage, p53 induces either cell-cycle arrest or apoptosis by differential transcription of several target genes and through transcription-independent apoptotic functions. p53 phosphorylation at Ser46 by HIPK2 is one determinant of

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Advances in the development of a methylation assay for FSHD

Autor: Calandra P.1, Cascino I.1, Lemmers R.J.2, Teveroni E.1, 3, Ricci E.4, Galluzzi G.1, Monforte M.4, Tasca G.5, Moretti F.1, van der Maarel S.M.2, Deidda G.1

Publikováno v: FSH Society Facioscapulohumeral Muscular Dystrophy [FSHD] 2015 International Research Consortium & Research Planning Meetings, Boston, MA 02210 USA, October 5-6, 2015
info:cnr-pdr/source/autori:Calandra P.1, Cascino I.1, Lemmers R.J.2, Teveroni E.1,3, Ricci E.4, Galluzzi G.1, Monforte M.4, Tasca G.5, Moretti F.1, van der Maarel S.M.2, Deidda G.1/congresso_nome:FSH Society Facioscapulohumeral Muscular Dystrophy [FSHD] 2015 International Research Consortium & Research Planning Meetings/congresso_luogo:Boston, MA 02210 USA/congresso_data:October 5-6, 2015/anno:2015/pagina_da:/pagina_a:/intervallo_pagine

Facioscapulohumeral muscular dystrophy is a disease linked to an epigenetic defect in the chromosome 4q subtelomere. This dystrophy is caused by contraction of the D4Z4 macrosatellite array on chromosome 4qter in FSHD1, or by functional impairment of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::da9616f13a9455c57bf7060d3382c891
https://publications.cnr.it/doc/363484