Role of Metformin and AKT Axis Modulation in the Reversion of Hypoxia Induced TMZ-Resistance in Glioma Cells Alessia Lo Dico1,2+, Silvia Valtorta2,3,4+, Luisa Ottobrini 1,2? and Rosa Maria Moresco2,3,4*? 1

Autor: Lo Dico A 1, 2, Valtorta S 2, 3, 4, Ottobrini L 1, Moresco RM 2

Publikováno v: Frontiers in oncology 9 (2019): 463. doi:10.3389/fonc.2019.00463
info:cnr-pdr/source/autori:Lo Dico A 1,2*, Valtorta S 2,3,4*, Ottobrini L 1,2 and Moresco RM 2,3,4/titolo:Role of Metformin and AKT Axis Modulation in the Reversion of Hypoxia Induced TMZ-Resistance in Glioma Cells Alessia Lo Dico1,2+, Silvia Valtorta2,3,4+, Luisa Ottobrini 1,2? and Rosa Maria Moresco2,3,4*? 1/doi:10.3389%2Ffonc.2019.00463/rivista:Frontiers in oncology/anno:2019/pagina_da:463/pagina_a:/intervallo_pagine:463/volume:9

Hypoxia is a key driver of tumor adaptation promoting tumor progression and resistance to therapy. Hypoxia related pathways might represent attractive targets for the treatment of Glioblastoma Multiforme (GBM), that up to date is characterized by a p

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