Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Moreno Wichert"'
Publikováno v:
CHIMIA, Vol 75, Iss 1-2 (2021)
Externí odkaz:
https://doaj.org/article/30f68c06a25047d0ad11169e31c69a5b
Autor:
Micah Steffek, Elizabeth Helgason, Nataliya Popovych, Lionel Rougé, John M. Bruning, Ke Sherry Li, Daniel J. Burdick, Jianping Cai, Terry Crawford, Jing Xue, Willy Decurtins, Chunlin Fang, Felix Grubers, Michael J. Holliday, Allyson Langley, Ann Petersen, Alexander Lee Satz, Aimin Song, Daniel Stoffler, Quentin Strebel, Jeffrey Y. K. Tom, Nicholas Skelton, Steven T. Staben, Moreno Wichert, Melinda M. Mulvihill, Erin C. Dueber
Publikováno v:
Biochemistry. 62:633-644
Autophagy-related proteins (Atgs) drive the lysosome-mediated degradation pathway, autophagy, to enable the clearance of dysfunctional cellular components and maintain homeostasis. In humans, this process is driven by the mammalian Atg8 (mAtg8) famil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c00ab7c9a5fb6957dbd609eeeeb525
https://doi.org/10.1021/acs.biochem.1c00682
https://doi.org/10.1021/acs.biochem.1c00682
Autor:
Raphael M. Franzini, Dario Neri, Willy Decurtins, Yixin Zhang, Moreno Wichert, Michael A. Stravs, Jörg Scheuermann, Fabian Buller
Publikováno v:
Nature Protocols
This protocol describes an approach for screening DNA-encoded chemical libraries (DECLs) to identify molecules that bind to proteins of interest. After isolating binding library members, DNA barcodes are amplified and identified by high-throughput se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a683d57f0faee9648e704d15aa934c
https://doi.org/10.1038/nprot.2016.039
https://doi.org/10.1038/nprot.2016.039
Autor:
Nikolaus Krall, Moreno Wichert
Publikováno v:
Current Opinion in Chemical Biology. 26:48-54
Carbonic anhydrase IX (CAIX) is expressed in many solid tumors in response to hypoxia and plays an important role in tumor acid-base homeostasis under these conditions. It is also constitutively expressed in the majority of renal cell carcinoma. Its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fef1e50216de9c1d9c4c095bf1c3115
https://doi.org/10.1016/j.cbpa.2015.02.005
https://doi.org/10.1016/j.cbpa.2015.02.005
Autor:
Raphael M. Franzini, Moreno Wichert, Francesca Pretto, Nikolaus Krall, Willy Decurtins, Petra Schneider, Jörg Scheuermann, Dario Neri
Publikováno v:
Nature chemistry
Nature Chemistry
Nature Chemistry
In contrast to standard fragment-based drug discovery approaches, dual-display DNA-encoded chemical libraries have the potential to identify fragment pairs that bind simultaneously and benefit from the chelate effect. However, the technology has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30a0e9c75c1949e28ceb3849e726080
Publikováno v:
Chemical communications (Cambridge England)
The identification of specific binding molecules is a central problem in chemistry, biology and medicine. Therefore, technologies, which facilitate ligand discovery, may substantially contribute to a better understanding of biological processes and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb903c6f59ba21b3f2c5003a4e27ec2
Autor:
Herwig Schüler, Mauro Zimmermann, Jonathan Hall, T. Ekblad, Moreno Wichert, Willy Decurtins, Nan Zhong, Jörg Scheuermann, Susanne Gräslund, Raphael M. Franzini, Angela Nauer, Florent Samain, Peter Brown, Dario Neri
Publikováno v:
Angewandte Chemie (International ed. in English). 54(13)
Methods for the rapid and inexpensive discovery of hit compounds are essential for pharmaceutical research and DNA-encoded chemical libraries represent promising tools for this purpose. We here report on the design and synthesis of DAL-100K, a DNA-en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931ba1300d5a1ffaec03d88d92eac029
https://pubmed.ncbi.nlm.nih.gov/25650139
https://pubmed.ncbi.nlm.nih.gov/25650139
Publikováno v:
ChemInform. 43
The identification of specific binding molecules is a central problem in chemistry, biology and medicine. Therefore, technologies, which facilitate ligand discovery, may substantially contribute to a better understanding of biological processes and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3663a55e6e4505f2851e65025e265188
https://doi.org/10.1002/chin.201211268
https://doi.org/10.1002/chin.201211268