Zobrazeno 1 - 10 of 81 pro vyhledávání: '"Moreno, Lelli"'
1
Akademický článek
Cerebrospinal fluid lipoproteins inhibit α-synuclein aggregation by interacting with oligomeric species in seed amplification assays
Autor: Giovanni Bellomo, Silvia Paciotti, Luis Concha-Marambio, Domenico Rizzo, Anna Lidia Wojdaƚa, Davide Chiasserini, Leonardo Gatticchi, Linda Cerofolini, Stefano Giuntini, Chiara Maria Giulia De Luca, Yihua Ma, Carly M. Farris, Giuseppe Pieraccini, Sara Bologna, Marta Filidei, Enrico Ravera, Moreno Lelli, Fabio Moda, Marco Fragai, Lucilla Parnetti, Claudio Luchinat
Publikováno v: Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-24 (2023)
Abstract Background Aggregation of α-synuclein (α-syn) is a prominent feature of Parkinson’s disease (PD) and other synucleinopathies. Currently, α-syn seed amplification assays (SAAs) using cerebrospinal fluid (CSF) represent the most promising
Externí odkaz: https://doaj.org/article/8a0abc545ac346ba9dc7517cc43c701f
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2
Akademický článek
Multitasking Pharmacophores Support Cabotegravir-Based Long-Acting HIV Pre-Exposure Prophylaxis (PrEP)
Autor: Zheng Wan, Man Shi, Yanqing Gong, Massimo Lucci, Jinjin Li, Jiahai Zhou, Xiao-Liang Yang, Moreno Lelli, Xiao He, Jiafei Mao
Publikováno v: Molecules, Vol 29, Iss 2, p 376 (2024)
Cabotegravir is an integrase strand transfer inhibitor (INSTI) for HIV treatment and prevention. Cabotegravir-based long-acting pre-exposure prophylaxis (PrEP) presents an emerging paradigm for infectious disease control. In this scheme, a combinatio
Externí odkaz: https://doaj.org/article/5221144881fc4da4a0031a15780336da
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3
Akademický článek
Mode of action of teixobactins in cellular membranes
Autor: Rhythm Shukla, João Medeiros-Silva, Anish Parmar, Bram J. A. Vermeulen, Sanjit Das, Alessandra Lucini Paioni, Shehrazade Jekhmane, Joseph Lorent, Alexandre M. J. J. Bonvin, Marc Baldus, Moreno Lelli, Edwin J. A. Veldhuizen, Eefjan Breukink, Ishwar Singh, Markus Weingarth
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
The natural antibiotic teixobactin kills bacteria by direct binding to their cognate cell wall precursors (Lipid II and III). Here authors use solid-state NMR to reveal the native binding mode of teixobactins and show that teixobactins only weakly bi
Externí odkaz: https://doaj.org/article/8a53feac384048deba131cc874db54f3
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4
Akademický článek
The lineage-specific, intrinsically disordered N-terminal extension of monothiol glutaredoxin 1 from trypanosomes contains a regulatory region
Autor: Mattia Sturlese, Bruno Manta, Andrea Bertarello, Mariana Bonilla, Moreno Lelli, Barbara Zambelli, Karin Grunberg, Stefano Mammi, Marcelo A. Comini, Massimo Bellanda
Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Glutaredoxins (Grx) are small proteins conserved throughout all the kingdoms of life that are engaged in a wide variety of biological processes and share a common thioredoxin-fold. Among them, class II Grx are redox-inactive proteins involve
Externí odkaz: https://doaj.org/article/d2ac22c55c0e492ba0d1f44f23cfdd25
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5
Multiple Surface Site Three-Dimensional Structure Determination of a Supported Molecular Catalyst
Autor: Ribal Jabbour, Marc Renom-Carrasco, Ka Wing Chan, Laura Völker, Pierrick Berruyer, Zhuoran Wang, Cory M. Widdifield, Moreno Lelli, David Gajan, Christophe Copéret, Chloé Thieuleux, Anne Lesage
Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, 2022, 144 (23), pp.10270-10281. ⟨10.1021/jacs.2c01013⟩
International audience; The structural characterization of supported molecular catalysts is challenging due to the low concentration of surface sites and the presence of several organic/organometallic surface groups resulting from the often complex s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff67ad8ea7e899b6eb11e311cc4b3e61
https://doi.org/10.1021/jacs.2c01013
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7
Optically enhanced solid-state 1H NMR spectroscopy
Autor: Federico De Biasi, Michael Hope, Claudia Avalos, Ganesan Karthikeyan, Gilles Casano, Aditya Mishra, Saumya Badoni, Gabriele Stevanato, Dominik Kubicki, Jonas Milani, Jean-Philippe Ansermet, Aaron Rossini, Moreno Lelli, Olivier Ouari, Lyndon Emsley
Publikováno v: Journal of Chemical Physics
Journal of Chemical Physics, 2023, 158 (18), ⟨10.26434/chemrxiv-2023-gdmxs⟩
Low sensitivity is the primary limitation to extending nuclear magnetic resonance (NMR) techniques to more advanced chemical and structural studies. Photochemically induced dynamic nuclear polarization (photo-CIDNP) is an NMR hyperpolarization techni
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13229cead805d90e0b5c2fdba7a32042
https://hal-amu.archives-ouvertes.fr/hal-04115805
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8
Trehalose matrices for high temperature dynamic nuclear polarization enhanced solid state NMR
Autor: Monu Kaushik, Hugo Lingua, Gabriele Stevanato, Margarita Elokova, Moreno Lelli, Anne Lesage, Olivier Ouari
Publikováno v: Physical Chemistry Chemical Physics
Physical Chemistry Chemical Physics, 2022, 24 (20), pp.12167-12175. ⟨10.1039/D2CP00970F⟩
Dynamic nuclear polarization (DNP) at cryogenic temperatures has proved to be a valuable technique to enhance the sensitivity of solid-state NMR spectroscopy. Over the years, sample formulations have been optimized for experiments at cryogenic temper
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28494b59b0e9930fb1bc6358758354f7
https://doi.org/10.1039/d2cp00970f
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10
Efficient Dynamic Nuclear Polarization up to 230 K with Hybrid BDPA-Nitroxide Radicals at a High Magnetic Field
Autor: Moreno Lelli, Alicia Lund, Gilles Casano, Anne Lesage, Maxim Yulikov, Olivier Ouari, Lorenzo Niccoli, Georges Menzildjian, Ganesan Karthikeyan, Gunnar Jeschke, David Gajan
Publikováno v: Journal of Physical Chemistry B
Journal of Physical Chemistry B, 2021, 125 (48), pp.13329-13338. ⟨10.1021/acs.jpcb.1c07307⟩
Pairing the spectral resolution provided by high magnetic fields at ambient temperature with the enhanced sensitivity offered by dynamic nuclear polarization (DNP) is a major goal of modern solid-state NMR spectroscopy, which will allow one to unlock
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a0e29ef50820d8b561828aefc71138
https://doi.org/10.1021/acs.jpcb.1c07307
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