Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor.

Autor: Tiago T; Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy., Hummel B; Max Planck Institute of Immunobiology and Epigenetics, 79108, Freiburg, Germany., Morelli FF; Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy., Basile V; Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy., Vinet J; Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy., Galli V; Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy., Mediani L; Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy., Antoniani F; Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy., Pomella S; Department of Oncohematology, Bambino Gesù Children's Hospital, IRCCS, 00165, Rome, Italy., Cassandri M; Department of Oncohematology, Bambino Gesù Children's Hospital, IRCCS, 00165, Rome, Italy., Garone MG; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, 00185, Rome, Italy., Silvestri B; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, 00185, Rome, Italy.; Center for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT), 00161, Rome, Italy., Cimino M; Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy., Cenacchi G; Department of Biomedical and Neuromotor Sciences DIBINEM, University of Bologna, Bologna, Italy; Centre for Applied Biomedical Research - CRBA, University of Bologna, IRCCS St. Orsola Hospital, Bologna, Italy., Costa R; Department of Biomedical and Neuromotor Sciences DIBINEM, University of Bologna, Bologna, Italy; Centre for Applied Biomedical Research - CRBA, University of Bologna, IRCCS St. Orsola Hospital, Bologna, Italy., Mouly V; Centre de Recherche en Myologie, Sorbonne Université, Inserm, Institut de Myologie, F-75013, Paris, France., Poser I; Max Planck Institute of Molecular Cell Biology and Genetics, 01307, Dresden, Germany.; Dewpoint Therapeutics GmbH, Tatzberg 47, 01307, Dresden, Germany., Yeger-Lotem E; Department of Clinical Biochemistry and Pharmacology and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, 84105, Israel., Rosa A; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, 00185, Rome, Italy.; Center for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT), 00161, Rome, Italy., Alberti S; Biotechnology Center (BIOTEC), Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Tatzberg 47/49, 01307, Dresden, Germany., Rota R; Department of Oncohematology, Bambino Gesù Children's Hospital, IRCCS, 00165, Rome, Italy., Ben-Zvi A; Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva, 84105, Israel., Sawarkar R; Max Planck Institute of Immunobiology and Epigenetics, 79108, Freiburg, Germany.; Medical Research Council (MRC), University of Cambridge, Cambridge, CB2 1QR, UK., Carra S; Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy. serena.carra@unimore.it.

Publikováno v: Cell death & disease [Cell Death Dis] 2021 May 06; Vol. 12 (5), pp. 452. Date of Electronic Publication: 2021 May 06.

Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks.

Autor: Meister-Broekema M; University Medical Center Groningen, University of Groningen, Department of Biomedical Sciences of Cell & Systems, Groningen, AV, 9791, The Netherlands., Freilich R; Institute for Neurodegenerative Disease, University of California at San Francisco, San Francisco, CA, 94158, USA., Jagadeesan C; University Medical Center Groningen, University of Groningen, Department of Biomedical Sciences of Cell & Systems, Groningen, AV, 9791, The Netherlands.; Max Planck Institute of Biochemistry, Martinsried/Munich, 82152, Germany., Rauch JN; Institute for Neurodegenerative Disease, University of California at San Francisco, San Francisco, CA, 94158, USA., Bengoechea R; Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Motley WW; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA., Kuiper EFE; University Medical Center Groningen, University of Groningen, Department of Biomedical Sciences of Cell & Systems, Groningen, AV, 9791, The Netherlands., Minoia M; University Medical Center Groningen, University of Groningen, Department of Biomedical Sciences of Cell & Systems, Groningen, AV, 9791, The Netherlands., Furtado GV; University Medical Center Groningen, University of Groningen, Department of Biomedical Sciences of Cell & Systems, Groningen, AV, 9791, The Netherlands.; Programa de Pós-Graduação em Genética e Biologia Molecular, Department of Genetics, Universidade Federal do Rio Grande do SulPorto Alegre, Porto Alegre, 15053, Brazil., van Waarde MAWH; University Medical Center Groningen, University of Groningen, Department of Biomedical Sciences of Cell & Systems, Groningen, AV, 9791, The Netherlands., Bird SJ; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Rebelo A; Department of Human Genetics and Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33136, USA., Zuchner S; Department of Human Genetics and Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33136, USA., Pytel P; Department of Neuropathology, University of Chicago Pritzker School of Medicine, Chicago, IL, 60637, USA., Scherer SS; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Morelli FF; Department of Biomedical, Metabolic and Neural Sciences, Center for Neuroscience and Nanotechnology, University of Modena and Reggio Emilia Modena, Modena, 41125, Italy., Carra S; University Medical Center Groningen, University of Groningen, Department of Biomedical Sciences of Cell & Systems, Groningen, AV, 9791, The Netherlands.; Department of Biomedical, Metabolic and Neural Sciences, Center for Neuroscience and Nanotechnology, University of Modena and Reggio Emilia Modena, Modena, 41125, Italy., Weihl CC; Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA. weihlc@wustl.edu., Bergink S; University Medical Center Groningen, University of Groningen, Department of Biomedical Sciences of Cell & Systems, Groningen, AV, 9791, The Netherlands. s.bergink@umcg.nl., Gestwicki JE; Institute for Neurodegenerative Disease, University of California at San Francisco, San Francisco, CA, 94158, USA. Jason.Gestwicki@ucsf.edu., Kampinga HH; University Medical Center Groningen, University of Groningen, Department of Biomedical Sciences of Cell & Systems, Groningen, AV, 9791, The Netherlands. h.h.kampinga@umcg.nl.

Publikováno v: Nature communications [Nat Commun] 2018 Dec 17; Vol. 9 (1), pp. 5342. Date of Electronic Publication: 2018 Dec 17.

An interaction study in mammalian cells demonstrates weak binding of HSPB2 to BAG3, which is regulated by HSPB3 and abrogated by HSPB8.

Autor: Morelli FF; Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, via G. Campi 287, 41125, Modena, Italy., Mediani L; Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, via G. Campi 287, 41125, Modena, Italy., Heldens L; Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, via G. Campi 287, 41125, Modena, Italy., Bertacchini J; Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, via G. Campi 287, 41125, Modena, Italy., Bigi I; Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, via G. Campi 287, 41125, Modena, Italy., Carrà AD; Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, via G. Campi 287, 41125, Modena, Italy., Vinet J; Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, via G. Campi 287, 41125, Modena, Italy., Carra S; Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, via G. Campi 287, 41125, Modena, Italy. serena.carra@unimore.it.; Department of Cell Biology, University Medical Center Groningen; University of Groningen, Groningen, The Netherlands. serena.carra@unimore.it.

Publikováno v: Cell stress & chaperones [Cell Stress Chaperones] 2017 Jul; Vol. 22 (4), pp. 531-540. Date of Electronic Publication: 2017 Feb 08.

A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism.

Autor: Ganassi M; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41125, Italy., Mateju D; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany., Bigi I; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41125, Italy., Mediani L; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41125, Italy., Poser I; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany., Lee HO; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany., Seguin SJ; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41125, Italy., Morelli FF; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41125, Italy., Vinet J; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41125, Italy., Leo G; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41125, Italy., Pansarasa O; Laboratory of Experimental Neurobiology, 'C. Mondino' National Institute of Neurology Foundation, IRCCS, Via Mondino 2, 27100 Pavia, Italy., Cereda C; Laboratory of Experimental Neurobiology, 'C. Mondino' National Institute of Neurology Foundation, IRCCS, Via Mondino 2, 27100 Pavia, Italy., Poletti A; Department of Pharmacological and Biomolecular Sciences, Centre of Excellence on Neurodegenerative Diseases University of Milan, Milan 20133, Italy., Alberti S; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany. Electronic address: alberti@mpi-cbg.de., Carra S; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41125, Italy. Electronic address: serena.carra@unimore.it.

Publikováno v: Molecular cell [Mol Cell] 2016 Sep 01; Vol. 63 (5), pp. 796-810. Date of Electronic Publication: 2016 Aug 25.

BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta: implications for a proteasome-to-autophagy switch.

Autor: Minoia M; Department of Cell Biology; University Medical Center Groningen; University of Groningen; Groningen, The Netherlands., Boncoraglio A; Department of Cell Biology; University Medical Center Groningen; University of Groningen; Groningen, The Netherlands; Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB); Università degli Studi di Milano; Centro di Eccellenza sulle Patologie Neurodegenerative (CEND); Milano, Italy., Vinet J; Dipartimento di Scienze Biomediche; Metaboliche e Neuroscienze; Università degli Studi di Modena e Reggio Emilia; Modena, Italy., Morelli FF; Dipartimento di Scienze Biomediche; Metaboliche e Neuroscienze; Università degli Studi di Modena e Reggio Emilia; Modena, Italy., Brunsting JF; Department of Cell Biology; University Medical Center Groningen; University of Groningen; Groningen, The Netherlands., Poletti A; Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB); Università degli Studi di Milano; Centro di Eccellenza sulle Patologie Neurodegenerative (CEND); Milano, Italy., Krom S; Departments of Cell Biology and Histology; University of Amsterdam; Academic Medical Center; Amsterdam, The Netherlands., Reits E; Departments of Cell Biology and Histology; University of Amsterdam; Academic Medical Center; Amsterdam, The Netherlands., Kampinga HH; Department of Cell Biology; University Medical Center Groningen; University of Groningen; Groningen, The Netherlands., Carra S; Department of Cell Biology; University Medical Center Groningen; University of Groningen; Groningen, The Netherlands; Dipartimento di Scienze Biomediche; Metaboliche e Neuroscienze; Università degli Studi di Modena e Reggio Emilia; Modena, Italy.

Publikováno v: Autophagy [Autophagy] 2014 Sep; Vol. 10 (9), pp. 1603-21. Date of Electronic Publication: 2014 Jul 10.