Methods for estimating survival benefits in the presence of treatment crossover: A simulation study (2012)

Autor: Latimer, N., P, Lambert, Crowther M, Abrams K, Wailoo A, Morden JP

Treatment crossover occurs when patients randomised to the control group of a clinical trial are permitted to switch onto the experimental treatment at some point during follow-up. It is common in oncology trials for a number of reasons, both practic

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Carpal tunnel syndrome and musculoskeletal symptoms in postmenopausal women with early breast cancer treated with exemestane or tamoxifen after 2-3 years of tamoxifen: a retrospective analysis of the Intergroup Exemestane Study

Autor: Mieog, Js, Morden, Jp, Bliss, Jm, Coombes, Rc, van de Velde CJ, IES Steering Committee: Delozier, T, Veronesi, A, Vrdoljak, E, Monnier, A, Coombes, C, Nagykalnai, T, Roumen, Rm, Utracka Hutka, B, Pluzanska, A, Porpiglia, M, Genta, F, Benedetto, Chiara, Sozzani, P, Steiner, M, Rubinov, R, Leviov, M, Semiglazov, V, Fox, J, Mayordomo, Ji, Cervek, J, Sleeboom, Hp, Jassem, J, Hinton, Cp, Paulsen, Th, Guleng, Rj, Fein, L, Gutulescu, N, Florián, J, Rosso, R, Rutgers, Ej, Krzakowski, M, Pienkowski, T, Krajina, Z, Siffnerova, H, Pawlicki, M, Drosik, K, Wagnerowa, M, Brunt, M, Vukelja, S, Mitrowic, L, Cataliotti, L, Karnicka Mlodkowska, H, Bonnefoi, H, Tilch, G, Chollet, P, Patel, A, Kamby, C, Giustini, L, Acito, L, Mouridsen, H, Roche, H, De Lafontan, B, Tomczak, P, Petruzelka, L, Lortholary, A, Pacquola, Mg, Skene, A, Rici, S, Michelotti, A, Ghilezan, N, Stewart, A, Beauduin, M, Andersen, J, Vassilaros, S, Celio, L, Bajetta, E, Bastús, R, Marsland, T, Paridaens, R, Tzekova, V, Lichtenegger, W, Piersma, H, Jones, S, Holmberg, S, Verhoeven, D, Hill, A, Porcile, G, Bruno, Mf, Chernozemski, I, Coleman, R, Jadeja, J, Cohn, A, Merlano, M, Perroni, D, Di Costanzo, F, Van Bochove, A, Gerrits, Ma, Malec, V, Balil, A, Mendiola, C, Dodwell, D, Knox, R, Horgan, K, Joannides, T, Leonard, Rc, Cawthorn, Sj, Ghosh, C, Cantrell, J, Campos, D, Orti, R, Diedrich, K, Aas, H, Barnadas, A, Vila, Mm, Makris, A, Anderson, T, Chittor, S, Michel, J, Philip, P, Redmond, P, Mastboom, Wj, Nordenskjöld, B, Simmonds, P, Grieve, Rj, Tomova, A, Piot, G, Borea, G, Ucci, G, Einarsson, E, Nicholson, S, Gardiol, Ea, Kerger, J, Schlosser, J, Namer, M, Pinotti, G, Rutten, Ht, Iversen, T, Nejim, A, Dudov, A, Grundtvig, P, Lang, I, Massidda, B, Van De Velde CH, Gervasio, Mh, Tengrup, I, Tennvall, L, Goodman, S, Modgill, Vk, Vorobiof, Da, Mickiewicz, E, Chirgwin, J, Focan, C, Albin, N, Contu, Aa, Svensson, Jh, Borghede, G, Källström, Ac, Forbes, Jf, Hurtz, Hj, Tubiana Hulin, M, Viens, P, Scanni, A, Arnoldi, E, Nastasi, G, Bottini, A, Alquati, P, Muscat, V, Brincat, S, Holmen, K, Amaral, N, Moreno, I, Trask, C, Robinson, A, Mcintyre, K, Otsuka, A, Hohaus, B, Hoefig, G, Georgoulias, V, Salvagni, S, Bidin, L, Artioli, F, Engan, T, Benedikstsson, Kp, Campbell, I, Harvey, V, Zimbler, H, Mrsic Krmpotic, Z, Canon, Jl, Tchilingirov, Pv, Buser, K, Bolanca, A, Reztke, U, Rhein, U, Jouve, M, Mullins, G, Vesentini, L, Gallo, L, Merlini, L, Decensi, A, Carreca, I, Van Tienhoven, G, Börjesson, B, Hansen, J, Koza, I, Arcusa, A, Inoriza, A, Pelegri, A, Eremin, O, Modiano, Mr, Anthony, S, Donat, D, Richardet, E, Kochli, O, Zeißig, P, Gauch, G, Aabo, K, Fumoleau, P, Erdkamp, Fl, Lovén, L, Jönsson, Pe, Perren, T, Stuart, N, Galindo, E, Marek, Bj, Salmon, Jp, Dohollou, N, Thompson, R, Folco, U, Rosa, A, Tonato, M, Heijmans, Gj, Koralewski, P, Bång, H, Lescure, Ar, Carrato, A, Martin, M, Neave, F, Howell, T, Savin, M, Loesch, D, Hannois, A, Mohr, A, Laube, T, Omar, S, Bonneterre, J, Servent, V, Danese, S, Sertoli, Mr, Butzelaar, Rm, Steller, Ep, Gomez, H, Skoog, P, Alvarez, I, Aguilar, Ea, Giner, Jl, Yosef, Hm, Barrett Lee, P, Buzdar, Au, George, T, Olivaires, J, Vsianska, M, Köhler, U, Lindeløv, B, Toftdahl, Db, Nielsen, Eb, Veyret, C, Castera, D, Kerbrat, P, Vassilaros, P, Yeo, W, Boni, C, Aitini, E, Luporini, G, Herben, Mg, Espelid, H, Dahl, S, Ingvar, C, Meana, A, Pico, C, Garcia, Am, Agrawal, Rk, Gruenberg, D, Nunez de Pierro, A, Gill, G, Nogaret, Jm, Honhon, B, Wassenaar, H, Nielander, R, Warnier, P, Sessa, C, Padrik, P, Guastalla, Jp, Serin, D, Jaubert, D, Dank, M, Given, Fh, Mascia, V, De Fraia, E, Silingardi, V, Conte, Pf, Labianca, R, Tondini, C, Bagnulo, A, Gardani, G, Wils, J, Liem, G, Nuytinck, Jk, Formoe, E, Ambré, T, Alés, J, Aramburo, P, Mansi, J, Graham, J, Joffe, J, Sainsbury, J, Stone, J, Good, Rh, Cartwright, T, Werner, Id, Murray, E, Beith, J, Tigges, Fj, Bojko, P, Sandberg, E, Jensen, B, Lotz, Jp, Carney, D, Shapira, J, Neumann, A, Goldhirsch, A, Dicato, M, de Graaf, H, Maartense, E, Burghouts, J, Cassinello, J, Jones, A, Gaffney, C, Blum, R, Abdi, E, Becquart, D, Dirix, L, Janssens, J, Nmarschner, N, Blaska Jaulerry, B, Prevot, G, Mirah Lev, L, Shani, A, Baruch, Nb, Peretz, T, Gips, M, Cognetti, F, Carlini, P, Nortier, Jw, Huinink D, ten B., Roussel, Jg, Unneberg, K, Kylberg, F, Hovind, H, Nestvold, T, Fogelkvist, R, Due, J, Muller, S, Gilligan, D, Russel, S, Mcaleer, J, Yiangou, C, Foote, L, Schottstaedt, M, Holmes, Fa, Wainstein, R, Contreras, O, Martinez, J, Della Fiorentina, S, Beslija, S, Vermorken, Jb, Thirion, M, Fraikin, J, Castiglione, M, Jäger, W, Fasching, P, Fabriz, H, Neis, K, Kirschbaum, M, Labat, Jp, Dupuis, O, Bernard, J, Datchary, J, Provencal, J, Allain, P, Clerico, M, Lopez, M, Nalli, G, Aspevik, R, Fràguas, A, Curescu, S, Cuevas, Jm, Oltra, A, Bradley, C, Kapoor, R, Akbain, S, Croghan, Mk, Modiano, M, Taetle, R, Beale, P, Gobert, P, Bondue, H, Böhm, R, Møller, Ka, Brettes, Jp, Netter, G, Grogan, L, Klein, B, Botta, M, Barni, S, Van Meerwijk, I, Kåresen, R, Godes, J, Aramburo, A, Jara, C, Zanger, B, Fleagle, Jt, Greenspan, A, Marschke, R, Medgyesy, Dc, Garbo, L.

Publikováno v: The Lancet Oncology
lancet oncology, 13(4), 420-432. Lancet Publishing Group

BACKGROUND: Aromatase inhibitors are more effective than is tamoxifen in prevention of breast-cancer recurrence, but at the expense of increased musculoskeletal side-effects, such as carpal tunnel syndrome. The aim of this study was to assess risk fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f1b1d912af1429249258a5916fae06d
https://hdl.handle.net/1887/120204

Clinico-pathologic relationships with Ki67 and its change with short-term aromatase inhibitor treatment in primary ER + breast cancer: further results from the POETIC trial (CRUK/07/015).

Autor: Bliss JM; Clinical Trials and Statistics Unit (ICR-CTSU), The Institute of Cancer Research, London, UK. Judith.bliss@icr.ac.uk., Tovey H; Clinical Trials and Statistics Unit (ICR-CTSU), The Institute of Cancer Research, London, UK., Evans A; Poole Hospital, Poole, UK., Holcombe C; Royal Liverpool University Hospital, Liverpool, UK., Horgan K; Department of Breast Surgery, St James's University Hospital, Leeds, UK., Mallon E; Western Infirmary, Glasgow, UK., Vidya R; Royal Wolverhampton NHS Trust, Wolverhampton, UK., Skene A; Royal Bournemouth Hospital, Bournemouth, UK., Dodson A; UK NEQAS for Immunocytochemistry and In-Situ Hybridisation, London, UK., Hills M; Ralph Lauren Centre for Breast Cancer Research, Royal Marsden Hospital, and Breast Cancer Now Centre, The Institute of Cancer Research, London, UK., Detre S; Ralph Lauren Centre for Breast Cancer Research, Royal Marsden Hospital, and Breast Cancer Now Centre, The Institute of Cancer Research, London, UK., Zabaglo L; Ralph Lauren Centre for Breast Cancer Research, Royal Marsden Hospital, and Breast Cancer Now Centre, The Institute of Cancer Research, London, UK., Banerji J; Clinical Trials and Statistics Unit (ICR-CTSU), The Institute of Cancer Research, London, UK., Kilburn L; Clinical Trials and Statistics Unit (ICR-CTSU), The Institute of Cancer Research, London, UK., Morden JP; Clinical Trials and Statistics Unit (ICR-CTSU), The Institute of Cancer Research, London, UK., Robertson JFR; Royal Derby Hospital, University of Nottingham, Derby, UK., Smith I; Breast Unit, Royal Marsden Hospital, London, UK., Dowsett M; Ralph Lauren Centre for Breast Cancer Research, Royal Marsden Hospital, and Breast Cancer Now Centre, The Institute of Cancer Research, London, UK.

Publikováno v: Breast cancer research : BCR [Breast Cancer Res] 2023 Apr 12; Vol. 25 (1), pp. 39. Date of Electronic Publication: 2023 Apr 12.

Dose-escalated intensity-modulated radiotherapy in patients with locally advanced laryngeal and hypopharyngeal cancers: ART DECO, a phase III randomised controlled trial.

Autor: Nutting CM; The Royal Marsden Hospital, London, UK. Electronic address: chris.nutting@rmh.nhs.uk., Griffin CL; The Institute of Cancer Research, London, UK., Sanghera P; Queen Elizabeth Hospital, Birmingham, UK., Foran B; Weston Park Hospital, Sheffield, UK., Beasley M; Bristol Haematology & Oncology Centre, Bristol, UK., Bernstein D; Department of Physics, The Royal Marsden Hospital, London, UK., Cosgrove V; St James' Hospital, Leeds, UK., Fisher S; University of Leeds, Leeds, UK., West CM; University of Manchester, Manchester, UK., Sibtain A; St Bartholomew's Hospital, London, UK., Palaniappan N; Velindre Hospital, Cardiff, UK., Urbano TG; Guy's and St Thomas' Hospitals, London, UK., Sen M; St James' Hospital, Leeds, UK., Soe W; Glan Clywd, Rhyll, UK., Rizwanullah M; Beatson West of Scotland Cancer Centre, Glasgow, UK., Wood K; Royal Surrey County Hospital, Guildford, UK., Ramkumar S; Southampton General Hospital, Southampton, UK., Junor E; Western General Hospital, Edinburgh, UK., Cook A; Cheltenham General Hospital, Cheltenham, UK., Roques T; Norfolk and Norwich University Hospital, UK., Scrase C; Ipswich Hospital, Ipswich, UK., Bhide SA; The Royal Marsden Hospital, London, UK., Gujral D; The Royal Marsden Hospital, London, UK., Harrington KJ; The Royal Marsden Hospital, London, UK., Mehanna H; The Institute for Head and Neck Studies and Education, University of Birmingham, Birmingham, UK., Miah A; The Royal Marsden Hospital, London, UK., Emson M; The Institute of Cancer Research, London, UK., Gardiner D; The Institute of Cancer Research, London, UK., Morden JP; The Institute of Cancer Research, London, UK., Hall E; The Institute of Cancer Research, London, UK.

Publikováno v: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2021 Aug; Vol. 153, pp. 242-256. Date of Electronic Publication: 2021 Jul 10.

Results of a multicentre randomised controlled trial of cochlear-sparing intensity-modulated radiotherapy versus conventional radiotherapy in patients with parotid cancer (COSTAR; CRUK/08/004).

Autor: Nutting CM; Head and Neck Unit, Royal Marsden Hospital, London, United Kingdom. Electronic address: Chris.Nutting@rmh.nhs.uk., Morden JP; The Institute of Cancer Research Clinical Trials and Statistics Unit, The Institute of Cancer Research, London, United Kingdom., Beasley M; Bristol Cancer Institute, Bristol Haematology and Oncology Centre, United Kingdom., Bhide S; Head and Neck Unit, Royal Marsden Hospital, London, United Kingdom., Cook A; Gloucestershire Oncology Centre, Cheltenham General Hospital, United Kingdom., De Winton E; Department of Oncology, Royal United Hospital, Bath, United Kingdom., Emson M; The Institute of Cancer Research Clinical Trials and Statistics Unit, The Institute of Cancer Research, London, United Kingdom., Evans M; Clinical Oncology, Velindre NHS Trust, United Kingdom., Fresco L; Department of Oncology, University Hospitals of Coventry and Warwickshire, United Kingdom., Gollins S; Department of Oncology, Glan Clwyd Hospital, Rhyl, United Kingdom., Gujral D; Head and Neck Department, Imperial College Healthcare NHS Trust, United Kingdom; Sarcoma Unit, Royal Marsden Hospital, Sutton, United Kingdom., Harrington K; Head and Neck Unit, Royal Marsden Hospital, London, United Kingdom., Joseph M; Oncology and Haematology Directorate, The Royal Wolverhampton NHS Trust, United Kingdom., Lemon C; Department of Oncology, Mount Vernon Hospital, United Kingdom., Luxon L; University College London Ear Institute, United Kingdom., van den Blink Q; Department of Oncology, Northampton General Hospital, United Kingdom., Mendes R; Department of Oncology, University College Hospital, London, United Kingdom., Miah A; Head and Neck Department, Imperial College Healthcare NHS Trust, United Kingdom; Sarcoma Unit, Royal Marsden Hospital, Sutton, United Kingdom., Newbold K; Head and Neck Unit, Royal Marsden Hospital, London, United Kingdom., Prestwich R; Department of Clinical Oncology, St James's University Hospital, Leeds, United Kingdom., Robinson M; Department of Clinical Oncology, Weston Park Hospital, Sheffield, United Kingdom., Sanghera P; Department of Oncology, University Hospitals Birmingham NHS Foundation Trust, United Kingdom., Simpson J; Department of Oncology, Royal Sussex County Hospital, United Kingdom., Sivaramalingam M; Department of Oncology, Royal Preston Hospital, United Kingdom., Srihari NN; Department of Oncology, Royal Shrewsbury Hospital, United Kingdom., Sydenham M; The Institute of Cancer Research Clinical Trials and Statistics Unit, The Institute of Cancer Research, London, United Kingdom., Wells E; QA Physics, Royal Marsden Hospital, London, United Kingdom., Witts S; The Institute of Cancer Research Clinical Trials and Statistics Unit, The Institute of Cancer Research, London, United Kingdom., Hall E; The Institute of Cancer Research Clinical Trials and Statistics Unit, The Institute of Cancer Research, London, United Kingdom.

Publikováno v: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2018 Nov; Vol. 103, pp. 249-258. Date of Electronic Publication: 2018 Oct 01.