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Akademický článek

Microglia-mediated synaptic pruning as a key deficit in neurodevelopmental disorders: Hype or hope?

Autor: Mordelt, Annika, de Witte, Lot D.

Publikováno v: In Current Opinion in Neurobiology April 2023 79

Akademický článek

CACNA1A haploinsufficiency leads to reduced synaptic function and increased intrinsic excitability.

Autor: Hommersom MP; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB Nijmegen, The Netherlands., Doorn N; Department of Clinical Neurophysiology, University of Twente, 7522 NB Enschede, The Netherlands., Puvogel S; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB Nijmegen, The Netherlands., Lewerissa EI; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB Nijmegen, The Netherlands., Mordelt A; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB Nijmegen, The Netherlands., Ciptasari U; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB Nijmegen, The Netherlands., Kampshoff F; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB Nijmegen, The Netherlands., Dillen L; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB Nijmegen, The Netherlands., van Beusekom E; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB Nijmegen, The Netherlands., Oudakker A; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB Nijmegen, The Netherlands., Kogo N; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB Nijmegen, The Netherlands., Dolga AM; Department of Pathology and Medical Biology, Division of Pathology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.; Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy, University of Groningen, 9713 AV Groningen, The Netherlands., Frega M; Department of Clinical Neurophysiology, University of Twente, 7522 NB Enschede, The Netherlands., Schubert D; Department of Cognitive Neurosciences, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB Nijmegen, The Netherlands., van de Warrenburg BPC; Department of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB Nijmegen, The Netherlands., Nadif Kasri N; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB Nijmegen, The Netherlands.; Department of Cognitive Neurosciences, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB Nijmegen, The Netherlands., van Bokhoven H; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB Nijmegen, The Netherlands.; Department of Cognitive Neurosciences, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB Nijmegen, The Netherlands.

Publikováno v: Brain : a journal of neurology [Brain] 2024 Oct 26. Date of Electronic Publication: 2024 Oct 26.

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Akademický článek

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HIV-1 infection of genetically engineered iPSC-derived central nervous system-engrafted microglia in a humanized mouse model

Autor: Alice K. Min, Behnam Javidfar, Roy Missall, Donald Doanman, Madel Durens, Samantha St Vil, Zahra Masih, Mara Graziani, Annika Mordelt, Samuele Marro, Lotje de Witte, Benjamin K. Chen, Talia H. Swartz, Schahram Akbarian

Publikováno v: bioRxiv

The central nervous system (CNS) is a major human immunodeficiency virus type 1 reservoir. Microglia are the primary target cell of HIV-1 infection in the CNS. Current models have not allowed the precise molecular pathways of acute and chronic CNS mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24ec0b7d17cf2c082815a66f9072942
https://europepmc.org/articles/PMC10168358/

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Microglia-mediated synaptic pruning as a key deficit in neurodevelopmental disorders: Hype or hope?

Autor: Annika Mordelt, Lot D. de Witte

Publikováno v: Current Opinion in Neurobiology, 79

Contains fulltext : 290684.pdf (Publisher’s version ) (Open Access) There is a consensus in the field that microglia play a prominent role in neurodevelopmental processes like synaptic pruning and neuronal network maturation. Thus, a current moment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ca32830bc69337707cac976dd3b94e
https://repository.ubn.ru.nl/handle/2066/290684

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Akademický článek

Detrimental Impact of Energy Drink Compounds on Developing Oligodendrocytes and Neurons

Autor: Meray Serdar, Annika Mordelt, Katharina Müser, Karina Kempe, Ursula Felderhoff-Müser, Josephine Herz, Ivo Bendix

Publikováno v: Cells, Vol 8, Iss 11, p 1381 (2019)

The consumption of energy drinks is continuously rising, particularly in children and adolescents. While risks for adverse health effects, like arrhythmia, have been described, effects on neural cells remain elusive. Considering that neurodevelopment

Externí odkaz: https://doaj.org/article/c6b57ad74b3d4bb79f034e26977cd3b7

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HIV-1 infection of genetically engineered iPSC-derived central nervous system-engrafted microglia in a humanized mouse model.

Autor: Min AK; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Javidfar B; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Missall R; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Doanman D; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Durens M; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Vil SS; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Masih Z; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Graziani M; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Mordelt A; Department of Human Genetics and Department of Cognitive Neuroscience, Radboud UMC, Nijmegen, Netherlands.; Centre for Neuroscience, Donders Institute for Brain, Cognition, and Behavior, Nijmegen, Netherlands., Marro S; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA., de Witte L; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Human Genetics and Department of Cognitive Neuroscience, Radboud UMC, Nijmegen, Netherlands.; Centre for Neuroscience, Donders Institute for Brain, Cognition, and Behavior, Nijmegen, Netherlands., Chen BK; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Swartz TH; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Akbarian S; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Apr 27. Date of Electronic Publication: 2023 Apr 27.

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