Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Mordecai P, Blaustein"'
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 323:H1281-H1295
Cloning of the “Na+ pump” (Na+,K+-ATPase or NKA) and identification of a circulating ligand, endogenous ouabain (EO), a cardiotonic steroid (CTS), triggered seminal discoveries regarding EO and its NKA receptor in cardiovascular function and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1345345ef94cf7afac112b32941534bc
https://doi.org/10.1152/ajpheart.00362.2022
https://doi.org/10.1152/ajpheart.00362.2022
Publikováno v:
Am J Physiol Heart Circ Physiol
Arterial smooth muscle Na(+)/Ca(2+) exchanger-1 (SM-NCX1) promotes vasoconstriction or vasodilation by mediating, respectively, Ca(2+) influx or efflux. In vivo, SM-NCX1 mediates net Ca(2+) influx to help maintain myogenic tone (MT) and neuronally ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7571212d87ccc163d2e2985a7498d8ec
https://doi.org/10.1152/ajpheart.00487.2020
https://doi.org/10.1152/ajpheart.00487.2020
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 321(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22b0fe5b00c222c7e55449a9d0947a2d
https://pubmed.ncbi.nlm.nih.gov/34842465
https://pubmed.ncbi.nlm.nih.gov/34842465
Autor:
Mordecai P. Blaustein, Alan R. Kay
Publikováno v:
The Journal of General Physiology
All animal cells are surrounded by a flexible plasma membrane that is permeable to water and to small ions. Cells thus face a fundamental problem: the considerable tension that their membranes would experience if the osmotic influx of water, driven b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd40a358cbafc3c109d92406a2102b88
https://doi.org/10.1085/jgp.201812274
https://doi.org/10.1085/jgp.201812274
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 316:H298-H310
Plasma membrane Na+/Ca2+ exchanger-1 (NCX1) helps regulate the cytosolic Ca2+ concentration ([Ca2+]CYT) in arterial myocytes. NCX1 mediates both Ca2+ entry and exit and tends to promote net Ca2+ entry in partially constricted arteries. Mean blood pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e84d45220471299109ac5d483b2bbd26
https://doi.org/10.1152/ajpheart.00185.2018
https://doi.org/10.1152/ajpheart.00185.2018
Autor:
John M Hamlyn, Cristina I Linde, Junjie Gao, Bing S Huang, Vera A Golovina, Mordecai P Blaustein, Frans H H Leenen
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108916 (2014)
Central nervous system (CNS) administration of angiotensin II (Ang II) raises blood pressure (BP). The rise in BP reflects increased sympathetic outflow and a slower neuromodulatory pressor mechanism mediated by CNS mineralocorticoid receptors (MR).
Externí odkaz:
https://doaj.org/article/0df3a099a042406bab64d41201224757
Autor:
Mordecai P, Blaustein, Vincenzo, Lariccia, Daniel, Khananshvili, Lucio, Annunziato, Alexei, Verkhratsky
Publikováno v:
Cell calcium. 87
Ionic signalling is the most ancient form of regulation of cellular functions in response to environmental challenges. Signals, mediated by Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0619fca2fac9fcee90eef77ea5bf0cf8
https://pubmed.ncbi.nlm.nih.gov/32006802
https://pubmed.ncbi.nlm.nih.gov/32006802
Autor:
Mordecai P. Blaustein
Publikováno v:
American Journal of Physiology-Cell Physiology. 314:C3-C26
Two prescient 1953 publications set the stage for the elucidation of a novel endocrine system: Schatzmann’s report that cardiotonic steroids (CTSs) are all Na+pump inhibitors, and Szent-Gyorgi’s suggestion that there is an endogenous “missing s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73650089231e07d4dcbcde82d600a953
https://doi.org/10.1152/ajpcell.00196.2017
https://doi.org/10.1152/ajpcell.00196.2017
Autor:
Monir Ahmad, Frans H. H. Leenen, Hong-Wei Wang, Mordecai P. Blaustein, Jiao Lu, Marzieh Keshtkar-Jahromi, John M. Hamlyn
Publikováno v:
Cardiovascular Research. 114:233-246
AimsHigh salt intake markedly enhances hypertension induced by angiotensin II (Ang II). We explored central and peripheral slow-pressor mechanisms which may be activated by Ang II and salt.Methods and resultsIn protocol I, Wistar rats were infused su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15cc4f1e66f02682a18389131e00601
https://doi.org/10.1093/cvr/cvx214
https://doi.org/10.1093/cvr/cvx214
Autor:
Mordecai P. Blaustein
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 313:H919-H930
Left ventricular hypertrophy is frequently observed in hypertensive patients and is believed to be due to the pressure overload and cardiomyocyte stretch. Three recent reports on mice with genetically engineered Na+pumps, however, have demonstrated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fd78e114442734ddbd762c2e70eb96a
https://doi.org/10.1152/ajpheart.00131.2017
https://doi.org/10.1152/ajpheart.00131.2017