Zobrazeno 1 - 10
of 601
pro vyhledávání: '"Moray J"'
Autor:
Lois Resnick-Silverman, Royce Zhou, Moray J. Campbell, Ian Leibling, Ramon Parsons, James J. Manfredi
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112216- (2023)
Summary: Thymus and spleen, in contrast to liver, are radiosensitive tissues in which p53-dependent apoptosis is triggered after whole-body radiation in vivo. Combined RNA sequencing (RNA-seq) and chromatin immunoprecipitation sequencing (ChIP-seq) a
Externí odkaz:
https://doaj.org/article/04d28b6c426d4492aceb89d8f6d7ad63
Autor:
Timothy H. Helms, Riley D. Mullins, Jennifer M. Thomas-Ahner, Samuel K. Kulp, Moray J. Campbell, Fabienne Lucas, Nathan Schmidt, Dana M. LeMoine, Surafel Getaneh, Zhiliang Xie, Mitch A. Phelps, Steven K. Clinton, Christopher C. Coss
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract A promotional role for androgen receptor (AR) signaling in hepatocellular carcinogenesis is emerging. In pre-clinical models, including diethylnitrosamine- (DEN-) induced hepatocellular carcinoma (HCC), anti-androgen therapies delay hepatoca
Externí odkaz:
https://doaj.org/article/c25b0208e10b4d27952527a2f7974c56
Autor:
Debasis Nayak, Brenna Weadick, Avinash K. Persaud, Radhika Raj, Reena Shakya, Junan Li, Moray J. Campbell, Rajgopal Govindarajan
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104193- (2022)
Summary: The involvement of membrane-bound solute carriers (SLCs) in neoplastic transdifferentiation processes is poorly defined. Here, we examined changes in the SLC landscape during epithelial-mesenchymal transition (EMT) of pancreatic cancer cells
Externí odkaz:
https://doaj.org/article/7f4a4a2d3e4b42b5a8bce96353c443e8
Autor:
Manjunath Siddappa, Sajad A. Wani, Mark D. Long, Damien A. Leach, Ewy A. Mathé, Charlotte L. Bevan, Moray J. Campbell
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract In prostate cancer (PCa), and many other hormone-dependent cancers, there is clear evidence for distorted transcriptional control as disease driver mechanisms. Defining which transcription factor (TF) and coregulators are altered and combine
Externí odkaz:
https://doaj.org/article/4631e065a23b463eb4e0b14a0f46990a
Autor:
Ji Young Kim, Yuntao Bai, Laura A. Jayne, Ralph D. Hector, Avinash K. Persaud, Su Sien Ong, Shreshtha Rojesh, Radhika Raj, Mei Ji He Ho Feng, Sangwoon Chung, Rachel E. Cianciolo, John W. Christman, Moray J. Campbell, David S. Gardner, Sharyn D. Baker, Alex Sparreboom, Rajgopal Govindarajan, Harpreet Singh, Taosheng Chen, Ming Poi, Katalin Susztak, Stuart R. Cobb, Navjot Singh Pabla
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Protein kinases have emerged as critical regulators of disease pathogenesis. Here, the authors have utilized kinome-wide screening approaches to reveal a pathogenic role of CDKL5 kinase in acute kidney injury, which is dependent on suppression of a S
Externí odkaz:
https://doaj.org/article/f36413dcdc0f4c47bbdac00ac1a34b20
Autor:
Mark D. Long, Justine J. Jacobi, Prashant K. Singh, Gerard Llimos, Sajad A. Wani, Aryn M. Rowsam, Spencer R. Rosario, Marlous Hoogstraat, Simon Linder, Jason Kirk, Hayley C. Affronti, Andries Bergman, Wilbert Zwart, Moray J. Campbell, Dominic J. Smiraglia
Publikováno v:
Cell Reports, Vol 37, Iss 11, Pp 110109- (2021)
Summary: This study addresses the roles of nuclear receptor corepressor 2 (NCOR2) in prostate cancer (PC) progression in response to androgen deprivation therapy (ADT). Reduced NCOR2 expression significantly associates with shorter disease-free survi
Externí odkaz:
https://doaj.org/article/4a042eabf97c4a9c95ff32cac4f01811
Autor:
Huy Q. Ta, Hilary Whitworth, Yi Yin, Mark Conaway, Henry F. Frierson, Moray J. Campbell, Ganesh V. Raj, Daniel Gioeli
Publikováno v:
Molecular Cancer, Vol 18, Iss 1, Pp 1-15 (2019)
Abstract Background Virtually all patients with metastatic prostate cancer (PCa) will relapse and develop lethal castration-resistant prostate cancer (CRPC). Long noncoding RNAs (lncRNAs) are emerging as critical regulatory elements of many cellular
Externí odkaz:
https://doaj.org/article/97e067ab31b04a57b24bf8cd63fd032c
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0249430 (2021)
The mammalian master circadian pacemaker within the suprachiasmatic nucleus (SCN) maintains tight entrainment to the 24 hr light/dark cycle via a sophisticated clock-gated rhythm in the responsiveness of the oscillator to light. A central event in th
Externí odkaz:
https://doaj.org/article/30b5555cc07c410ca7912653ccd4a4f2
Autor:
Swetha Rajasekaran, Lakshmi Dhevi Nagarajha Selvan, Kathleen Dotts, Ranjith Kumar, Pukhraj Rishi, Vikas Khetan, Madhoolika Bisht, Karthikeyan Sivaraman, Subrmanian Krishnakumar, Debashis Sahoo, Moray J. Campbell, Sailaja V. Elchuri, Wayne O. Miles
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Retinoblastoma is a rare pediatric tumor of the retina, caused by the homozygous loss of the Retinoblastoma 1 (RB1) tumor suppressor gene. Previous microarray studies have identified changes in the expression profiles of coding genes; however, our un
Externí odkaz:
https://doaj.org/article/c49322c08aac45aea838803e8daebc54
