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Probing the nature of the cluster effect observed with synthetic multivalent galactosides and PNA lectin

Autor: Almant, M., Mastouri, A., Gallergo-Yerga, L., Garcia-Fernandez, J. M., Ortiz Mellet, C., Kovensky, J., Morandat, S., Karim EL KIRAT, Gouin, S. G.

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2013, 19, pp.729-738
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International audience; We designed a set of multi-galactosides with valencies ranging from one to seven and different spacer-arm lengths. The compounds display a high structural homology for a strict assessment of multivalent phenomena. The multimer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d4bb370134c28fbe4b5614a8219cc9c1
https://hal.science/hal-00782707

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Cytochrome c provokes the weakening of zwitterionic membranes as measured by force spectroscopy

Autor: Morandat, S., Karim EL KIRAT

Publikováno v: Colloids and Surfaces B: Biointerfaces
Colloids and Surfaces B: Biointerfaces, Elsevier, 2011, 82, pp.111-117
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International audience; Cytochrome c (cyt c) is a small soluble protein from the intermembrane space of mitochondria. This protein is essential because it transfers electrons between two membrane complexes of the respiratory chain. In fact, during th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b53234ffa393e032af61311020a7b3d1
https://hal.archives-ouvertes.fr/hal-00535995

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The potent antimalarial peptide cyclosporin a induces the aggregation and permeabilization of sphingomyelin-rich membranes

Autor: Azouzi, S., Morandat, S., Karim EL KIRAT

Publikováno v: Langmuir
Langmuir, American Chemical Society, 2011, 27, pp.9465-9472
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International audience; Cyclosporin A (CsA) is a hydrophobic peptide drug produced by the fungus Tolypocladium inflatum. CsA is commonly used as an immunosuppressive drug, but it also has antimalarial activity. The immunosuppressive activity of CsA i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::02ff509b894aff688c0ddbc384641f87
https://hal.archives-ouvertes.fr/hal-00637393

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The potent antimalarial drug cyclosporin A preferentially destabilizes sphingomyelin-rich membranes

Autor: Azouzi, S., El Kirat, K., Morandat, S.

Publikováno v: Langmuir
Langmuir, American Chemical Society, 2010, 26, pp.1960-1965

International audience; Cyclosporin A (CsA) is a hydrophobic cyclic peptide produced by a fungus. CsA is widely used as an immunosuppressive agent to inhibit the rejection of transplanted organs. CsA also exhibits an antiparasitic activity against Pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::79d18c7280457dee32abf0a2685b3c91
https://hal.archives-ouvertes.fr/hal-00468460

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Akademický článek

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Akademický článek

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Cytochrome c interaction with neutral lipid membranes: influence of lipid packing and protein charges

Autor: Karim EL KIRAT, Morandat, S.

Publikováno v: Chemistry and Physics of Lipids
Chemistry and Physics of Lipids, Elsevier, 2009, 162, pp.17-24
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International audience; The interaction of cytochrome c (cyt c) with fluid/gel neutral supported lipid membranes was investigated by time-lapse atomic force microscopy (AFM). AFM revealed the random formation of depressed areas in fluid membranes pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0109af017bfec6689e50bb7ea08541d2
https://hal.archives-ouvertes.fr/hal-00437701

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