Výsledky vyhledávání - "Morana Vojnic"

Akademický článek

Low-grade B-cell lymphomas in the spinal epidural space: A case series and review of the literature

Autor: Sandra Leskinen, Hamza Khilji, Faina Ablyazova, Avraham Zlochower, Manju Harshan, A. Gabriella Wernicke, Morana Vojnic, Randy S. D'Amico

Publikováno v: Current Problems in Cancer: Case Reports, Vol 12, Iss , Pp 100269- (2023)

Lymphoma rarely arises within the central nervous system and occurs most commonly in association with disseminated systemic disease. Primary epidural lymphomas of the spine are infrequently encountered and are usually high-grade, diffuse large B-cell

Externí odkaz: https://doaj.org/article/a5210c735db64bb792fa9d3077094543

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Akademický článek

NTRK kinase domain mutations in cancer variably impact sensitivity to type I and type II inhibitors

Autor: Romel Somwar, Nicolle E. Hofmann, Bryan Smith, Igor Odintsov, Morana Vojnic, Irina Linkov, Ashley Tam, Inna Khodos, Marissa S. Mattar, Elisa de Stanchina, Daniel Flynn, Marc Ladanyi, Alexander Drilon, Ujwal Shinde, Monika A. Davare

Publikováno v: Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)

Romel Somwar et al. find that cancer-causing NTRK gene fusions resistant to one form of inhibitor therapy can be resistant to other inhibitor types. Using molecular simulations, they show that some NTRK1 mutations resistant to the type I inhibitor la

Externí odkaz: https://doaj.org/article/dc4dd666029c45298c0ddd64355c90c2

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Akademický článek

Novel patient-derived models of desmoplastic small round cell tumor confirm a targetable dependency on ERBB signaling

Publikováno v: Disease Models & Mechanisms, Vol 15, Iss 1 (2022)

Desmoplastic small round cell tumor (DSRCT) is characterized by the t(11;22)(p13;q12) translocation, which fuses the transcriptional regulatory domain of EWSR1 with the DNA-binding domain of WT1, resulting in the oncogenic EWSR1-WT1 fusion protein. T

Externí odkaz: https://doaj.org/article/7b83f47a6c8e4d5eb829d9ab77a3d402

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Akademický článek

RET inhibition in novel patient-derived models of RET fusion- positive lung adenocarcinoma reveals a role for MYC upregulation

Publikováno v: Disease Models & Mechanisms, Vol 14, Iss 2 (2021)

Multi-kinase RET inhibitors, such as cabozantinib and RXDX-105, are active in lung cancer patients with RET fusions; however, the overall response rates to these two drugs are unsatisfactory compared to other targeted therapy paradigms. Moreover, the

Externí odkaz: https://doaj.org/article/2e7e848718f248f5b1b70bad579df39d

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Intrathecal therapy for the management of leptomeningeal metastatic disease: a scoping review of the current literature and ongoing clinical trials

Autor: Paolo Palmisciano, Gina Watanabe, Andie Conching, Christian Ogasawara, Morana Vojnic, Randy S. D’Amico

Publikováno v: Journal of Neuro-Oncology. 160:79-100

Leptomeningeal metastatic disease (LMD) from advanced malignancies has poor prognoses and limited treatments. Intrathecal therapy (ITT) protocols are available, showing variable outcomes. We reviewed the therapeutic and toxicity profiles of ITT in LM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d2f94c3d933e9e00319cc7d18aa7b2
https://doi.org/10.1007/s11060-022-04118-0

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