Zobrazeno 1 - 10
of 263
pro vyhledávání: '"Moran, Rosalyn J."'
Fine-tuning neural excitation/inhibition for tailored ketamine use in treatment-resistant depression
Autor:
Fagerholm, Erik D., Leech, Robert, Williams, Steven, Zarate Jr., Carlos A., Moran, Rosalyn J., Gilbert, Jessica R.
The glutamatergic modulator ketamine has been shown to rapidly reduce depressive symptoms in patients with treatment-resistant major depressive disorder (TRD). Although its mechanisms of action are not fully understood, changes in cortical excitation
Externí odkaz:
http://arxiv.org/abs/2102.03180
The principle of stationary action is a cornerstone of modern physics, providing a powerful framework for investigating dynamical systems found in classical mechanics through to quantum field theory. However, computational neuroscience, despite its h
Externí odkaz:
http://arxiv.org/abs/2010.02993
Autor:
Friston, Karl J., Parr, Thomas, Zeidman, Peter, Razi, Adeel, Flandin, Guillaume, Daunizeau, Jean, Hulme, Oliver J., Billig, Alexander J., Litvak, Vladimir, Price, Cathy J., Moran, Rosalyn J., Costello, Anthony, Pillay, Deenan, Lambert, Christian
This technical report addresses a pressing issue in the trajectory of the coronavirus outbreak; namely, the rate at which effective immunity is lost following the first wave of the pandemic. This is a crucial epidemiological parameter that speaks to
Externí odkaz:
http://arxiv.org/abs/2006.09429
Autor:
Friston, Karl J., Parr, Thomas, Zeidman, Peter, Razi, Adeel, Flandin, Guillaume, Daunizeau, Jean, Hulme, Oliver J., Billig, Alexander J., Litvak, Vladimir, Price, Cathy J., Moran, Rosalyn J., Lambert, Christian
By equipping a previously reported dynamic causal model of COVID-19 with an isolation state, we modelled the effects of self-isolation consequent on tracking and tracing. Specifically, we included a quarantine or isolation state occupied by people wh
Externí odkaz:
http://arxiv.org/abs/2005.07994
Autor:
Fagerholm, Erik D., Tangwiriyasakul, Chayanin, Friston, Karl J., Violante, Inês R., Williams, Steven, Carmichael, David W., Perani, Suejen, Turkheimer, Federico E., Moran, Rosalyn J., Leech, Robert, Richardson, Mark P.
Seizure activity is a ubiquitous and pernicious pathophysiology that, in principle, should yield to mathematical treatments of (neuronal) ensemble dynamics - and therefore interventions on stochastic chaos. A seizure can be characterised as a deviati
Externí odkaz:
http://arxiv.org/abs/2005.00805
Autor:
Friston, Karl J., Parr, Thomas, Zeidman, Peter, Razi, Adeel, Flandin, Guillaume, Daunizeau, Jean, Hulme, Oliver J., Billig, Alexander J., Litvak, Vladimir, Price, Cathy J., Moran, Rosalyn J., Lambert, Christian
We recently described a dynamic causal model of a COVID-19 outbreak within a single region. Here, we combine several of these (epidemic) models to create a (pandemic) model of viral spread among regions. Our focus is on a second wave of new cases tha
Externí odkaz:
http://arxiv.org/abs/2004.13017
Autor:
Friston, Karl J., Parr, Thomas, Zeidman, Peter, Razi, Adeel, Flandin, Guillaume, Daunizeau, Jean, Hulme, Oliver J., Billig, Alexander J., Litvak, Vladimir, Moran, Rosalyn J., Price, Cathy J., Lambert, Christian
This technical report describes a dynamic causal model of the spread of coronavirus through a population. The model is based upon ensemble or population dynamics that generate outcomes, like new cases and deaths over time. The purpose of this model i
Externí odkaz:
http://arxiv.org/abs/2004.04463
Autor:
Moran, Rosalyn J., Fagerholm, Erik D., Cullen, Maell, Daunizeau, Jean, Richardson, Mark P., Williams, Steven, Turkheimer, Federico, Leech, Rob, Friston, Karl J.
We used Bayesian model inversion to estimate epidemic parameters from the reported case and death rates from seven countries using data from late January 2020 to April 5th 2020. Two distinct generative model types were employed: first a continuous ti
Externí odkaz:
http://arxiv.org/abs/2004.05060
We begin by demonstrating that the neuronal state equation from Dynamic Causal Modelling takes on the form of the discretized Fokker-Planck equation upon the inclusion of local activity gradients within a network. Using the Jacobian of this modified
Externí odkaz:
http://arxiv.org/abs/1911.11409
Autor:
Fagerholm, Erik D., Foulkes, W. M. C., Gallero-Salas, Yasir, Helmchen, Fritjof, Friston, Karl J., Moran, Rosalyn J., Leech, Robert
In contrast to the symmetries of translation in space, rotation in space, and translation in time, the known laws of physics are not universally invariant under transformation of scale. However, the action can be invariant under change of scale in th
Externí odkaz:
http://arxiv.org/abs/1911.00775