550 Harnessing natural IL-18 activity through IL-18BP blockade reshapes the tumor microenvironment for potent anti-tumor immune response

Autor: Gady Cojocaru, Tal Fridman Kfir, Eran Ophir, Zoya Alteber, Pierre Ferre, Masha Frenkel, Assaf Menachem, Dan Blat, Olga Leiderman, Moran Galperin, Lital Sever, Nadav Cohen, Keren Cohen, Roy Granit, Sandra Vols, Lior Faigenbloom, Liron Soffer, Karin Meyer, Keren Menachem, Hadas Galon Tilleman, Michal Perpinial, Evgeny Tatirovsky

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/1a9f382ede6b446a84d8e97f71a1e662

COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade

Autor: Gady Cojocaru, Margaret L. Tang, Patrick Wall, Sandeep Kumar, Eran Ophir, Hsin-Yuan Cheng, John J. Hunter, Ling Leung, Andrew W. Drake, Maya F. Kotturi, Masha Frenkel, Kathryn Logronio, David Bernados, Moran Galperin, Kyle Hansen, Spencer Liang, Samir Qurashi, Mark A. White, Zoya Alteber, Sarah Whelan

Publikováno v: Cancer Immunology, Immunotherapy. 70:3525-3540

Immune checkpoint inhibitors (ICIs) have emerged as promising therapies for the treatment of cancer. However, existing ICIs, namely PD-(L)1 and CTLA-4 inhibitors, generate durable responses only in a subset of patients. TIGIT is a co-inhibitory recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3956f7736390726882c24308715f5566
https://doi.org/10.1007/s00262-021-02921-8

CD4+ T cell-mediated HLA class II cross-restriction in HIV controllers

Autor: Daniela Benati, Moran Galperin, Jamie Rossjohn, Lisa Ciacchi, Amandine Decroos, Lisa A. Chakrabarti, Hugh H. Reid, Dhilshan Jayasinghe, Stephanie Gras, Madhura Mukhopadhyay, Li Lynn Tan, C. Farenc

Publikováno v: Science Immunology
Science Immunology, American Association for the Advancement of Science, 2018, 3 (24), pp.eaat0687. ⟨10.1126/sciimmunol.aat0687⟩
Science Immunology, 2018, 3 (24), pp.eaat0687. ⟨10.1126/sciimmunol.aat0687⟩

International audience; Rare individuals, termed HIV controllers, spontaneously control HIV infection by mounting efficient T cell responses against the virus. Protective CD4+ T cell responses from HIV controllers involve high-affinity public T cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1364c6d98ab51af27681c72e4a2ec1
https://hdl.handle.net/11380/1169081

MHC Class II Tetramer Labeling of Human Primary CD4(+) T Cells from HIV Infected Patients

Autor: Madhura Mukhopadhyay, Mathieu Claireaux, Daniela Benati, Lisa A. Chakrabarti, Moran Galperin

Publikováno v: Bio Protoc

Major Histocompatibility Complex (MHC) tetramers have been used for two decades to detect, isolate and characterize T cells specific for various pathogens and tumor antigens. In the context of Human Immunodeficiency Virus (HIV) infection, antigen-spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980ac9ca394ce4803dea9895c3270832
https://europepmc.org/articles/PMC8376602/

Comparison of the antigen sensitivity of Gag-specific CD4+ T cell responses in controlled HIV infection and HIV vaccination

Autor: Madhura, Mukhopadhyay, Moran, Galperin, Alexandre, Nouël, Sandhya, Vasan, David D, Ho, Fast, P., Olivier, Lambotte, Daniela Benati, Chakrabarti, And Lisa A.

Publikováno v: Università degli studi di Modena e Reggio Emilia-IRIS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6584d873b0f98430a536dd6ad2c78c8c
https://hdl.handle.net/11380/1154961