Alternative molecular mechanisms for force transmission at adherens junctions via β-catenin-vinculin interaction.

Autor: Morales-Camilo N; Laboratory for Molecular Mechanics of Cell Adhesion, Faculty of Biological Sciences, Pontificia Universidad Católica De Chile, Santiago, Chile., Liu J; Department of Physics, National University of Singapore, 117542, Singapore, Singapore., Ramírez MJ; Laboratory for Molecular Mechanics of Cell Adhesion, Faculty of Biological Sciences, Pontificia Universidad Católica De Chile, Santiago, Chile.; Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile., Canales-Salgado P; Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.; Faculty of Medical Sciences, Universidad de Santiago de Chile, Santiago, Chile., Alegría JJ; Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.; Millennium Institute for Foundational Research on Data (IMFD), Santiago, Chile., Liu X; Department of Physics, National University of Singapore, 117542, Singapore, Singapore.; Mechanobiology Institute, Singapore, National University of Singapore, 117411, Singapore, Singapore., Ong HT; Mechanobiology Institute, Singapore, National University of Singapore, 117411, Singapore, Singapore., Barrera NP; Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile., Fierro A; Department of Organic Chemistry, School of Chemistry, Faculty of Chemistry and Pharmacy, Pontificia Universidad Católica de Chile, Santiago, Chile., Toyama Y; Mechanobiology Institute, Singapore, National University of Singapore, 117411, Singapore, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore, 117543, Singapore., Goult BT; School of Biosciences, University of Kent, Kent, Canterbury, CT2 7NJ, UK.; Department of Biochemistry, Cell & Systems Biology, Institute of Systems, Molecular & Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK., Wang Y; Mechanobiology Institute, Singapore, National University of Singapore, 117411, Singapore, Singapore., Meng Y; Mechanobiology Institute, Singapore, National University of Singapore, 117411, Singapore, Singapore., Nishimura R; Mechanobiology Institute, Singapore, National University of Singapore, 117411, Singapore, Singapore., Fong-Ngern K; Mechanobiology Institute, Singapore, National University of Singapore, 117411, Singapore, Singapore., Low CSL; Mechanobiology Institute, Singapore, National University of Singapore, 117411, Singapore, Singapore., Kanchanawong P; Mechanobiology Institute, Singapore, National University of Singapore, 117411, Singapore, Singapore.; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, 117543, Singapore, Singapore., Yan J; Department of Physics, National University of Singapore, 117542, Singapore, Singapore.; Mechanobiology Institute, Singapore, National University of Singapore, 117411, Singapore, Singapore., Ravasio A; Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile. and.ravasio@gmail.com., Bertocchi C; Laboratory for Molecular Mechanics of Cell Adhesion, Faculty of Biological Sciences, Pontificia Universidad Católica De Chile, Santiago, Chile. cristina.bertocchi@gmail.com.; Graduate School of Engineering Science, Osaka University, Osaka, Japan. cristina.bertocchi@gmail.com.

Publikováno v: Nature communications [Nat Commun] 2024 Jul 05; Vol. 15 (1), pp. 5608. Date of Electronic Publication: 2024 Jul 05.

Synthesis, Biological Evaluation, and Molecular Simulation of Chalcones and Aurones as Selective MAO-B Inhibitors.

Autor: Morales-Camilo N; Departamento de Química Orgánica, Facultad de Química, Pontificia Universidad Católica de Chile, Santiago de Chile, 702843, Chile., Salas CO; Departamento de Química Orgánica, Facultad de Química, Pontificia Universidad Católica de Chile, Santiago de Chile, 702843, Chile., Sanhueza C; Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago, Casilla 442, Correo 2, Santiago, Chile., Espinosa-Bustos C; Departamento de Química Orgánica, Facultad de Química, Pontificia Universidad Católica de Chile, Santiago de Chile, 702843, Chile., Sepúlveda-Boza S; Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago, Casilla 442, Correo 2, Santiago, Chile., Reyes-Parada M; Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago, Casilla 442, Correo 2, Santiago, Chile.; Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Santiago 8910124, Chile., Gonzalez-Nilo F; Universidad Andrés Bello, Facultad de Ciencias Biológicas, Centro de Bioinformática y Biología Integrativa, Santiago 8370146, Chile., Caroli-Rezende M; Departamento de Química de los Materiales, Facultad de Química y Biología, Universidad de Santiago de Chile, Casilla 40, Correo 33, Santiago, 9170022, Chile., Fierro A; Departamento de Química Orgánica, Facultad de Química, Pontificia Universidad Católica de Chile, Santiago de Chile, 702843, Chile.

Publikováno v: Chemical biology & drug design [Chem Biol Drug Des] 2015 Jun; Vol. 85 (6), pp. 685-95. Date of Electronic Publication: 2014 Nov 15.

Positional scanning of natural product hispidol's ring-B: discovery of highly selective human monoamine oxidase-B inhibitor analogues downregulating neuroinflammation for management of neurodegenerative diseases.

Autor: Hassan, Ahmed H. E.^1,2, Hyeon Jeong Kim³, Min Sung Gee⁴, Jong-Hyun Park³, Hye Rim Jeon⁵, Cheol Jung Lee⁵, Yeonwoo Choi⁵, Suyeon Moon⁵, Danbi Lee⁴, Jong Kil Lee⁴, Ki Duk Park^3,6, Yong Sup Lee^2,5,6 kyslee@khu.ac.kr

Publikováno v: Journal of Enzyme Inhibition & Medicinal Chemistry. 2022, Vol. 37 Issue 1, p768-780. 13p.

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Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity.

Autor: Guglielmi, Paolo¹ (AUTHOR), Secci, Daniela¹ (AUTHOR), Petzer, Anél² (AUTHOR), Bagetta, Donatella^3,4 (AUTHOR), Chimenti, Paola¹ (AUTHOR), Rotondi, Giulia¹ (AUTHOR), Ferrante, Claudio⁵ (AUTHOR), Recinella, Lucia⁵ (AUTHOR), Leone, Sheila⁵ (AUTHOR), Alcaro, Stefano^3,4 (AUTHOR), Zengin, Gokhan⁶ (AUTHOR), Petzer, Jacobus P.² (AUTHOR), Ortuso, Francesco^3,4 (AUTHOR), Carradori, Simone⁵ (AUTHOR) simone.carradori@unich.it

Publikováno v: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2019, Vol. 34 Issue 1, p1511-1525. 15p.