Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates.

Autor: Dias Viegas FP; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., de Freitas Silva M; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., Divino da Rocha M; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., Castelli MR; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., Riquiel MM; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., Machado RP; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., Vaz SM; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., Simões de Lima LM; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., Mancini KC; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., Marques de Oliveira PC; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., Morais ÉP; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., Gontijo VS; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil., da Silva FMR; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, RJ 21941-902, Brazil., D'Alincourt da Fonseca Peçanha D; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, RJ 21941-902, Brazil., Castro NG; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, RJ 21941-902, Brazil., Neves GA; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, RJ 21941-902, Brazil., Giusti-Paiva A; Institute of Biomedical Sciences, Federal University of Minas Gerais, MG 37130-000, Brazil., Vilela FC; Institute of Biomedical Sciences, Federal University of Minas Gerais, MG 37130-000, Brazil., Orlandi L; Institute of Biomedical Sciences, Federal University of Minas Gerais, MG 37130-000, Brazil., Camps I; Institute of Exact Sciences, Federal University of Alfenas, MG 37130-000, Brazil., Veloso MP; Faculty of Pharmacy, Federal University of Alfenas, MG 37130-000, Brazil., Leomil Coelho LF; Laboratory of Vaccines, Institute of Biomedical Sciences, Federal University of Alfenas, MG 37130-000, Brazil., Ionta M; Institute of Biomedical Sciences, Federal University of Minas Gerais, MG 37130-000, Brazil., Ferreira-Silva GÁ; Institute of Biomedical Sciences, Federal University of Minas Gerais, MG 37130-000, Brazil., Pereira RM; Institute of Biomedical Sciences, Federal University of Minas Gerais, MG 37130-000, Brazil., Dardenne LE; National Laboratory of Computational Sciences, Petrópolis, RJ 25651-075, Brazil., Guedes IA; National Laboratory of Computational Sciences, Petrópolis, RJ 25651-075, Brazil., de Oliveira Carneiro Junior W; Institute of Biological Sciences, Federal University of Minas Gerais, MG 31270-901, Brazil., Quaglio Bellozi PM; Institute of Biological Sciences, Federal University of Minas Gerais, MG 31270-901, Brazil., Pinheiro de Oliveira AC; Institute of Biological Sciences, Federal University of Minas Gerais, MG 31270-901, Brazil., Ferreira FF; Centre of Natural and Human Sciences, Federal University of ABC, Santo André, SP 09210-580, Brazil., Pruccoli L; Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, Rimini 47921, Italy., Tarozzi A; Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, Rimini 47921, Italy., Viegas C Jr; Institute of Chemistry, Laboratory of Research on Medicinal Chemistry, Federal University of Alfenas, MG 37133-840, Brazil. Electronic address: cvjviegas@gmail.com.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2018 Mar 10; Vol. 147, pp. 48-65. Date of Electronic Publication: 2018 Jan 31.